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The map label for this gene is cobC [H]

Identifier: 16764020

GI number: 16764020

Start: 705072

End: 705680

Strand: Reverse

Name: cobC [H]

Synonym: STM0643

Alternate gene names: 16764020

Gene position: 705680-705072 (Counterclockwise)

Preceding gene: 16764022

Following gene: 16764019

Centisome position: 14.53

GC content: 57.8

Gene sequence:

>609_bases
ATGCGATTGTGGCTGGTGCGTCATGGCGAAACCGAGGCCAATGTCGCCGGGTTGTATAGCGGACATGCTCCCACGCCGTT
AACGGAAAAAGGGATTGGCCAGGCGAAAACGCTACATACTTTATTGCGCCACGCGCCATTTGACCGGGTGTTATGCAGCG
AGCTGGAGCGCGCGCGCCATACCGCCCGGCTCGTACTGGAGGGCCGGGATGTGCCGCAACACATCTTACCTGAGCTTAAT
GAGATGTACTTTGGCGACTGGGAAATGCGCCATCACCGCGACCTCACCCATGAAGATGCCGAAAGCTATGCCGCCTGGTG
TACGGACTGGCAGAATGCGGTTCCGACCAATGGCGAGGGTTTTCAGGCTTTTACCCGGCGCGTAGAGCGCTTTATCTCGC
GACTCGACGCGTTTAGCGATTGCCAGAACCTGCTGATCGTCAGCCATCAGGGCGTACTCAGCCTGTTGATTGCCCGTCTG
CTCACAATGCCCGCCGCCTCGCTATGGCATTTCCGGGTAGAACAGGGATGCTGGAGCGCAATCGACATATGCGAAGGGTT
CGCCACCCTGAAAGTATTAAATAGTCGTGCCGTCTGGCGGCCTGAGTGA

Upstream 100 bases:

>100_bases
CCATTATGCCTCCAGCCAAAAAACGCTATTTTAGTGAAAAAAACGTTGCGCAATCAGGGGCATTATCATGTTTTGCGCAT
TTAACCTCATGAGGAATACC

Downstream 100 bases:

>100_bases
TGAATTTTCCGTTTTTTCTCGCCGCAGCGGTTTCGCCCATTGACAGCCCCCGACAGGCTGTTATTCTCCGCAGCCAGGCT
TTTTTCACCTTGCAGAGCTT

Product: alpha ribazole-5'-P phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDVPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARL
LTMPAASLWHFRVEQGCWSAIDICEGFATLKVLNSRAVWRPE

Sequences:

>Translated_202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDVPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARL
LTMPAASLWHFRVEQGCWSAIDICEGFATLKVLNSRAVWRPE
>Mature_202_residues
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDVPQHILPELN
EMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARL
LTMPAASLWHFRVEQGCWSAIDICEGFATLKVLNSRAVWRPE

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=198, Percent_Identity=74.2424242424242, Blast_Score=321, Evalue=3e-89,
Organism=Escherichia coli, GI1790856, Length=187, Percent_Identity=26.7379679144385, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324857, Length=173, Percent_Identity=31.2138728323699, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 23124; Mature: 23124

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARH
CEEEEEECCCCCCCHHHEECCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TARLVLEGRDVPQHILPELNEMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEG
HHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCH
FQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARLLTMPAASLWHFRVEQGCWSA
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IDICEGFATLKVLNSRAVWRPE
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARH
CEEEEEECCCCCCCHHHEECCCCCCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TARLVLEGRDVPQHILPELNEMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEG
HHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCH
FQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARLLTMPAASLWHFRVEQGCWSA
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IDICEGFATLKVLNSRAVWRPE
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]