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The map label for this gene is citT [H]

Identifier: 16763995

GI number: 16763995

Start: 680905

End: 682368

Strand: Reverse

Name: citT [H]

Synonym: STM0618

Alternate gene names: 16763995

Gene position: 682368-680905 (Counterclockwise)

Preceding gene: 16763996

Following gene: 16763994

Centisome position: 14.05

GC content: 53.69

Gene sequence:

>1464_bases
ATGTCTTTATCCAAAGATAATATATGGAAGTTGTTGGCCCCATTAGTGGTGATGGGCGTCATGTTGTTAATTCCTGTTCC
AGATGGTATGCCGCCGCAGGCCTGGCACTATTTTGCGGTTTTCGTCGCGATGATTGTCGGTATGATCCTGGAGCCGATCC
CGGCGACAGCGATCAGTTTTATCGCCGTAACCATTTGCGTTATCGGCAGCAATTACCTGCTATTTGACGCTTCAGAACTG
GCCGATCCGGCGTTTAAAGCCAGTAAACAGGCGCTGAAATGGGGGCTTGCCGGTTTCTCCAGCACCACGGTCTGGCTGGT
TTTCGGCGCGTTTATTTTCGCGCTGGGCTACGAAGTGACCGGGCTGGGGCGCCGCATTGCGCTGTTTTTGGTAAAATTCA
TGGGTAAACGCACGCTGACGCTCGGCTATGCGATTGTCATTATCGATATTTTGCTGGCGCCGTTTACTCCCTCCAATACG
GCTCGTACCGGCGGGACTGTCTTCCCGGTCATCAAGAACCTGCCGCCGCTGTTTAAATCGTTTCCAAACGATCCTTCCGC
ACGCCGCATCGGCGGTTATTTGATGTGGATGATGGTGATCAGTACCAGCCTGAGCTCTTCGATGTTTGTCACTGGCGCGG
CCCCGAACGTATTAGGTCTGGAGTTCGTCAGCAAGATCGCTGGCGTCCAGATTAGCTGGCTGCAGTGGTTTCTCAGCTTT
CTGCCGGTAGGGATTATTTTACTGATCGTTGCGCCGTGGCTCTCCTATGTACTTTATAAACCTGAAGTGACCCACAGTGC
GGAAGTCGCGGCCTGGGCTGGCGGCGAGTTAAAAAACATGGGGCGTCTGTCCCGCAAAGAGTGGACGCTGATTGGCCTGG
TGCTGCTTAGCTTAGGATTGTGGGTTTTTGGTGGAAAAATCATCAACGCCACTGCCGTGGGTCTGCTGGCCGTCTCGCTG
ATGCTGGCGTTGCATGTTGTGCCGTGGAAAGATATTACGCGCTACAACAGCGCCTGGAACACCCTGGTGAACCTCGCTAC
GCTGGTGGTCATGGCCAATGGCTTAACCCGCTCCGGCTTTATTGACTGGTTCGCCAATACCATGAGTACGCATCTGGAAG
GTTTCTCTCCGGATGCAACCGTGATTGTACTGGTACTGGTGTTCTATTTCGCGCACTATCTGTTCGCCAGTCTTTCCGCT
CACACCGCGACCATGCTGCCGGTCATTCTGGCGGTGGGTAAAGGCATTCCGGGCGTTCCGATGGAACAACTGTGTATTCT
GCTGGTGCTGTCTATCGGTATCATGGGCTGTCTGACGCCGTATGCCACCGGCCCTGGTGTGATTATCTACGGCTGCGGTT
ACGTGAAATCCAGAGACTACTGGCGGCTTGGCGCAATCTTTGGCGTTATCTATATCGCGATGCTGTTGCTGGTGGGCTGG
CCGATTTTGGCAATGTGGAATTAA

Upstream 100 bases:

>100_bases
GGTAGCGCCGATCTGCTGATCGTGACCTGGTTTTTAGCGCAAATTTCGCAAGTTAATCATTAACACAATTATAGAAAATA
TCCTTTCCGGAGAGTCATTT

Downstream 100 bases:

>100_bases
ACATTACGCCAACGCAGGTTAAAAATGATGCCGTTCAGGTTCACCTGAGCGGCATTTTTTATGATTAAATGGGTAACATT
CATAATGTGTATAAATTATC

Product: citrate/succinate transport antiport protein

Products: NA

Alternate protein names: Citrate transporter; Citrate/succinate antiporter [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSLSKDNIWKLLAPLVVMGVMLLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASEL
ADPAFKASKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNT
ARTGGTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQISWLQWFLSF
LPVGIILLIVAPWLSYVLYKPEVTHSAEVAAWAGGELKNMGRLSRKEWTLIGLVLLSLGLWVFGGKIINATAVGLLAVSL
MLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSA
HTATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLVGW
PILAMWN

Sequences:

>Translated_487_residues
MSLSKDNIWKLLAPLVVMGVMLLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASEL
ADPAFKASKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNT
ARTGGTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQISWLQWFLSF
LPVGIILLIVAPWLSYVLYKPEVTHSAEVAAWAGGELKNMGRLSRKEWTLIGLVLLSLGLWVFGGKIINATAVGLLAVSL
MLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSA
HTATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLVGW
PILAMWN
>Mature_486_residues
SLSKDNIWKLLAPLVVMGVMLLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASELA
DPAFKASKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTA
RTGGTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQISWLQWFLSFL
PVGIILLIVAPWLSYVLYKPEVTHSAEVAAWAGGELKNMGRLSRKEWTLIGLVLLSLGLWVFGGKIINATAVGLLAVSLM
LALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSAH
TATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLVGWP
ILAMWN

Specific function: Responsible for the uptake of citrate in exchange to the efflux of succinate. Has a relatively broad specificity for C(4)- dicarboxylates and tricarboxylates [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. SODIT1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786829, Length=487, Percent_Identity=94.8665297741273, Blast_Score=928, Evalue=0.0,
Organism=Escherichia coli, GI1789444, Length=471, Percent_Identity=45.4352441613588, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1786986, Length=493, Percent_Identity=33.4685598377282, Blast_Score=258, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52940; Mature: 52809

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSKDNIWKLLAPLVVMGVMLLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISF
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IAVTICVIGSNYLLFDASELADPAFKASKQALKWGLAGFSSTTVWLVFGAFIFALGYEVT
HHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHH
GLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCHHHHC
FPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQISWLQWFLSF
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LPVGIILLIVAPWLSYVLYKPEVTHSAEVAAWAGGELKNMGRLSRKEWTLIGLVLLSLGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVFGGKIINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGF
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKGIPGVP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLVGW
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PILAMWN
CHHCCCC
>Mature Secondary Structure 
SLSKDNIWKLLAPLVVMGVMLLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IAVTICVIGSNYLLFDASELADPAFKASKQALKWGLAGFSSTTVWLVFGAFIFALGYEVT
HHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHH
GLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCHHHHC
FPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQISWLQWFLSF
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LPVGIILLIVAPWLSYVLYKPEVTHSAEVAAWAGGELKNMGRLSRKEWTLIGLVLLSLGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVFGGKIINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGF
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKGIPGVP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLVGW
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PILAMWN
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]