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The map label for this gene is purK [H]

Identifier: 16763913

GI number: 16763913

Start: 596052

End: 597119

Strand: Reverse

Name: purK [H]

Synonym: STM0533

Alternate gene names: 16763913

Gene position: 597119-596052 (Counterclockwise)

Preceding gene: 16763914

Following gene: 16763908

Centisome position: 12.29

GC content: 59.27

Gene sequence:

>1068_bases
ATGAAGCAAGTTTGCGTTCTCGGCAACGGACAACTGGGCCGAATGCTGCGCCAGGCGGGCGAACCGCTGGGTATCGCCGT
CTGGCCGGTTGGTCTGGATGCAGAGCCTACCGCCGTGCCGGTACAGCAGAGCGTCATTACCGCAGAGATTGAGCGCTGGC
CGGAAACCGCGCTTACCCGCGAGCTGGCGCGCCACCCGGCCTTCGTCAATCGCGATGTATTTCCGATCATCGCCGACCGT
CTGACACAAAAACAGCTTTTCGATAAACTGGGACTCGCGACCGCGCCGTGGCAGCTGCTGACCAGCACCGACGAGTGGTC
CGGCATCTTTGACCGCCTGGGCGAACTGGCGATTATTAAGCGTCGCGTTGGCGGCTACGACGGTCGCGGGCAGTGGCGTC
TACGCGCGGACGAAACCGGGCAACTGCCGGATGACTGCTATGGCGAATGTATTGTTGAGCGCGGTATCCATTTTTCCGGC
GAAGTGTCGTTAGTCGGCGCGCGCGCTCATGACGGCAGTACCGTGTTTTACCCGCTAACGCACAATTTGCATCAGGACGG
CATCTTGCGGACCAGCGTCGCGTTCCCACAGGCGAACGCCGAACAGCAGGAGCAGGCGGAATCGATGCTGTCAGCAATTA
TGCAGGCGCTGAACTACGTCGGCGTAATGGCGATGGAATGTTTTATCACGCCGGAAGGCCTGTTAATCAATGAACTGGCG
CCGCGCGTGCATAACAGCGGACACTGGACGCAAAATGGCGCCAGCATCAGTCAGTTTGAATTGCATTTGCGCGCGATTAC
CGGCCTGCCGTTGCCCGCGCCGGTGATTAACGCCCCGTCGGTGATGATCAACCTGATCGGCAGCGAGCTGAATTACGACT
GGCTGAAGCTGCCGCTGGTACATCTGCACTGGTATGATAAAGCGGTACGTCCGGGGCGAAAAGTCGGCCATCTGAATCTG
ACCGACAGCGATACGTCACGTCTTAGCGCCACCCTGGAAGCGCTCTCTCCGCTCCTGCCAGGCGAATACGCCAGCGGCAT
TATCTGGGCGCAAAGTAAGCTTAAATAA

Upstream 100 bases:

>100_bases
TTCTGGCGCAACACGACGCGGAACTGCATCAGCGCATTGCCGACTGGCGCAAAGCGCAAACCGATGAAGTTCTGGAAAAT
CCCGATCCGCGGGGGACGCT

Downstream 100 bases:

>100_bases
ACAGCGTGGGCGGCGCATTCTCTGTTGCCGCCCGTCGCGATCACAGACAGATGCAGGTTCCCGCCCTGCCCGCCAGGGTA
TCATCAATACGCGACAGCGC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIKRRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSG
EVSLVGARAHDGSTVFYPLTHNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLVHLHWYDKAVRPGRKVGHLNL
TDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK

Sequences:

>Translated_355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIKRRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSG
EVSLVGARAHDGSTVFYPLTHNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLVHLHWYDKAVRPGRKVGHLNL
TDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK
>Mature_355_residues
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR
LTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIKRRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSG
EVSLVGARAHDGSTVFYPLTHNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELA
PRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLVHLHWYDKAVRPGRKVGHLNL
TDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=354, Percent_Identity=88.7005649717514, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1788155, Length=303, Percent_Identity=27.0627062706271, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324702, Length=385, Percent_Identity=28.3116883116883, Blast_Score=135, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39142; Mature: 39142

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
ELARHPAFVNRDVFPIIADRLTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSGEVSLVGARAHDGSTVFYPLT
HHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
HNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELA
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH
PRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLV
HHHCCCCCCCCCCCCHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCEE
HLHWYDKAVRPGRKVGHLNLTDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK
EEEEHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHCCEEEECCCCC
>Mature Secondary Structure
MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPTAVPVQQSVITAEIERWPETALTR
CCCEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
ELARHPAFVNRDVFPIIADRLTQKQLFDKLGLATAPWQLLTSTDEWSGIFDRLGELAIIK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
RRVGGYDGRGQWRLRADETGQLPDDCYGECIVERGIHFSGEVSLVGARAHDGSTVFYPLT
HHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
HNLHQDGILRTSVAFPQANAEQQEQAESMLSAIMQALNYVGVMAMECFITPEGLLINELA
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHH
PRVHNSGHWTQNGASISQFELHLRAITGLPLPAPVINAPSVMINLIGSELNYDWLKLPLV
HHHCCCCCCCCCCCCHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCEE
HLHWYDKAVRPGRKVGHLNLTDSDTSRLSATLEALSPLLPGEYASGIIWAQSKLK
EEEEHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2464576; 2644189; 9278503; 1534690; 10569930 [H]