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The map label for this gene is hemH

Identifier: 16763869

GI number: 16763869

Start: 546914

End: 547876

Strand: Direct

Name: hemH

Synonym: STM0489

Alternate gene names: 16763869

Gene position: 546914-547876 (Clockwise)

Preceding gene: 16763868

Following gene: 16763871

Centisome position: 11.26

GC content: 56.8

Gene sequence:

>963_bases
ATGCGTCAGACGAAAACCGGTATCCTGCTGGCTAACCTTGGCACGCCAGATGCCCCAACTCCTGAAGCGGTAAAGCGTTA
CCTGAAACAATTTTTAAGCGACAGACGCGTGGTGGATACTCCTCGTCTGCTGTGGTGGCCGCTGCTGCGTGGCGTTATTT
TACCGCTGCGTTCGCCGCGCGTCGCGAAACTCTATCAATCTATCTGGATGGATGGCGGTTCGCCGCTCATGGTATATAGC
CGCGAACAGCAACAGGCGCTGGCCGCGCGGTTGCCAGATACGCCCGTCGCGCTGGGGATGAGCTACGGCTCGCCCTCGCT
GGAAAGCGCTGTCGATGAACTGTTAGCAAGCGACGTCGACCATATCGTCGTGCTGCCGTTGTACCCGCAATACTCTTGCT
CAACGGTGGGCGCAGTCTGGGACGAACTGGGGCGGATACTGGCGCGTAAACGTCGTATTCCCGGTATCTCATTTATTCGC
GATTACGCGGATGACGGCGCTTATATCGATGCGCTGGCGAAAAGCGCGCGTGAGTCGTTCGCCAGGCACGGCGAGCCCGA
TGTGCTTCTGCTCTCCTATCACGGCATTCCACAACGTTATGCGGATGAAGGCGATGACTATCCGCAGCGCTGCCGCGATA
CCACGCGCGAACTGGTTTCCGCATTGGGACTGCCGCCGGAAAAGGTAATGATGACGTTCCAGTCGCGCTTTGGCCGTGAA
CCGTGGCTGACGCCGTACACCGATGAAACGCTAAAAATGTTGGGTGAAAAGGGGACTGGCCATATTCAGGTTATGTGTCC
GGGATTTGCCGCGGATTGTCTGGAGACGCTGGAAGAGATAGCGGAACAGAACCGCGAGATTTTCCTTGAAGCGGGCGGTA
AAAAATATGCGTACATTCCGGCGCTGAACGCGACGCCGGAACATATTGATATGATGCTGAAACTCACGGCGCCGTACCGT
TAA

Upstream 100 bases:

>100_bases
GCCATTCGGCAAATTCTCGTCTTACCTCTCGCAGCAATTAGTTCTTCTTTATCGCTTTTCCGCTACAATTATCAACAATT
TGAATAGATAAGAGGCGGCA

Downstream 100 bases:

>100_bases
CGCGGCGTCTTCATCCTCGCCATAAAGAAGCGTGCGCCGTCCTGCAAGGCATCGTCGGCGATTGTCATCATTCGCGAATA
GTGCAGAAAGGCGTGCAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI60499021, Length=323, Percent_Identity=27.8637770897833, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=88.75, Blast_Score=571, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6324750, Length=294, Percent_Identity=26.8707482993197, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=26.7857142857143, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=27.8810408921933, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_SALA4 (B5EXN2)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002145473.1
- ProteinModelPortal:   B5EXN2
- SMR:   B5EXN2
- PRIDE:   B5EXN2
- GeneID:   6794501
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B0535
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35915; Mature: 35915

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIP
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
ALNATPEHIDMMLKLTAPYR
CCCCCHHHHHHHHEECCCCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIP
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
ALNATPEHIDMMLKLTAPYR
CCCCCHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA