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The map label for this gene is prpC [H]

Identifier: 16763749

GI number: 16763749

Start: 418987

End: 420156

Strand: Direct

Name: prpC [H]

Synonym: STM0369

Alternate gene names: 16763749

Gene position: 418987-420156 (Clockwise)

Preceding gene: 16763748

Following gene: 16763750

Centisome position: 8.63

GC content: 55.73

Gene sequence:

>1170_bases
ATGACAGACACGACGATCCTGCAAAACAACACGCATGTCATTAAGCCTAAAAAATCGGTCGCGCTTTCCGGCGTACCTGC
CGGAAATACCGCTCTGTGTACCGTGGGAAAAAGCGGTAACGATCTGCACTATCGCGGTTACGACATTCTCGATCTGGCGG
AGCACTGCGAATTTGAAGAAGTCGCGCATTTACTGATCCACGGAAAATTACCGACCCGCGACGAGCTGAACGCGTATAAA
AGCAAGTTAAAAGCGCTGCGCGGATTACCCGCCAATGTCCGTACCGTTCTGGAAGCGTTACCGGCGGCCTCGCACCCGAT
GGACGTGATGCGTACCGGCGTCTCCGCGCTGGGCTGCACCCTGCCGGAAAAAGAGGGACATACCGTCTCCGGCGCGCGCG
ATATTGCCGATAAGCTGTTGGCCTCGCTCAGCTCTATCCTTCTTTACTGGTATCACTACAGCCACAACGGCGAACGTATT
CAGCCGGAAACCGACGATGATTCCATCGGCGGCCATTTCCTGCATCTGCTGCACGGTGAAAAGCCAACCCAAAGCTGGGA
AAAGGCGATGCATATTTCGCTGGTGCTGTATGCCGAGCATGAGTTCAACGCCTCGACGTTTACCAGCCGGGTGATTGCCG
GGACTGGCTCGGATGTCTACTCCGCGATTATCGGCGCGATTGGCGCGCTGCGCGGCCCGAAACACGGCGGGGCGAATGAG
GTGTCGCTGGAAATTCAACAGCGTTATGAAACGCCGGACGAGGCAGAGGCGGATATCCGTAAACGCGTGGAAAACAAAGA
GGTGGTGATTGGCTTTGGACATCCGGTTTACACCATCGCCGACCCGCGCCATCAGGTGATCAAACGGGTGGCGAAACAGC
TTTCAGAAGAAGGCGGCTCGCTGAAGATGTACCACATCGCCGACCGTCTGGAAACGGTGATGTGGGAGACCAAAAAGATG
TTCCCGAATCTCGACTGGTTTTCGGCGGTCTCCTACAACATGATGGGCGTCCCTACCGAAATGTTCACCCCGCTGTTTGT
CATCGCCCGCGTTACCGGCTGGGCGGCGCACATTATTGAACAGCGTCAGGACAACAAAATTATTCGCCCCTCTGCCAACT
ATACCGGGCCGGAAGATCGTCCGTTTGTCTCGATAGACGATCGTTGCTAA

Upstream 100 bases:

>100_bases
GCCGCCATCAGGCAATGCCGGATGGCACTACGTTTAACCCGCCTACGGTACGGCCTACACGCCTCAATACCCTACACATT
ACAATAATGACGAGGACAAT

Downstream 100 bases:

>100_bases
CTCACTCTTATTAAAAATAAAACGCAGGAAACGTACCCTATGTCTACCCAAGAACTGAACATCCGCCCAGACTTTGACCG
TGAAATCGTTGATATCGTTG

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTDTTILQNNTHVIKPKKSVALSGVPAGNTALCTVGKSGNDLHYRGYDILDLAEHCEFEEVAHLLIHGKLPTRDELNAYK
SKLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCTLPEKEGHTVSGARDIADKLLASLSSILLYWYHYSHNGERI
QPETDDDSIGGHFLHLLHGEKPTQSWEKAMHISLVLYAEHEFNASTFTSRVIAGTGSDVYSAIIGAIGALRGPKHGGANE
VSLEIQQRYETPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQVIKRVAKQLSEEGGSLKMYHIADRLETVMWETKKM
FPNLDWFSAVSYNMMGVPTEMFTPLFVIARVTGWAAHIIEQRQDNKIIRPSANYTGPEDRPFVSIDDRC

Sequences:

>Translated_389_residues
MTDTTILQNNTHVIKPKKSVALSGVPAGNTALCTVGKSGNDLHYRGYDILDLAEHCEFEEVAHLLIHGKLPTRDELNAYK
SKLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCTLPEKEGHTVSGARDIADKLLASLSSILLYWYHYSHNGERI
QPETDDDSIGGHFLHLLHGEKPTQSWEKAMHISLVLYAEHEFNASTFTSRVIAGTGSDVYSAIIGAIGALRGPKHGGANE
VSLEIQQRYETPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQVIKRVAKQLSEEGGSLKMYHIADRLETVMWETKKM
FPNLDWFSAVSYNMMGVPTEMFTPLFVIARVTGWAAHIIEQRQDNKIIRPSANYTGPEDRPFVSIDDRC
>Mature_388_residues
TDTTILQNNTHVIKPKKSVALSGVPAGNTALCTVGKSGNDLHYRGYDILDLAEHCEFEEVAHLLIHGKLPTRDELNAYKS
KLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCTLPEKEGHTVSGARDIADKLLASLSSILLYWYHYSHNGERIQ
PETDDDSIGGHFLHLLHGEKPTQSWEKAMHISLVLYAEHEFNASTFTSRVIAGTGSDVYSAIIGAIGALRGPKHGGANEV
SLEIQQRYETPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQVIKRVAKQLSEEGGSLKMYHIADRLETVMWETKKMF
PNLDWFSAVSYNMMGVPTEMFTPLFVIARVTGWAAHIIEQRQDNKIIRPSANYTGPEDRPFVSIDDRC

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=388, Percent_Identity=96.3917525773196, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1786939, Length=365, Percent_Identity=31.7808219178082, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17555174, Length=358, Percent_Identity=25.1396648044693, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319850, Length=389, Percent_Identity=23.9074550128535, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324328, Length=331, Percent_Identity=25.9818731117825, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24640124, Length=330, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640126, Length=330, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356863, Length=358, Percent_Identity=22.0670391061453, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 43174; Mature: 43042

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTILQNNTHVIKPKKSVALSGVPAGNTALCTVGKSGNDLHYRGYDILDLAEHCEFEE
CCCCEEEECCCEEECCCCCEEECCCCCCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHH
VAHLLIHGKLPTRDELNAYKSKLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCT
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
LPEKEGHTVSGARDIADKLLASLSSILLYWYHYSHNGERIQPETDDDSIGGHFLHLLHGE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHEEEECCCC
KPTQSWEKAMHISLVLYAEHEFNASTFTSRVIAGTGSDVYSAIIGAIGALRGPKHGGANE
CCHHHHHHHEEEEEEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCC
VSLEIQQRYETPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQVIKRVAKQLSEEGGS
EEEEHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCC
LKMYHIADRLETVMWETKKMFPNLDWFSAVSYNMMGVPTEMFTPLFVIARVTGWAAHIIE
EEEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QRQDNKIIRPSANYTGPEDRPFVSIDDRC
HHCCCCEECCCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure 
TDTTILQNNTHVIKPKKSVALSGVPAGNTALCTVGKSGNDLHYRGYDILDLAEHCEFEE
CCCEEEECCCEEECCCCCEEECCCCCCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHH
VAHLLIHGKLPTRDELNAYKSKLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCT
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
LPEKEGHTVSGARDIADKLLASLSSILLYWYHYSHNGERIQPETDDDSIGGHFLHLLHGE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHEEEECCCC
KPTQSWEKAMHISLVLYAEHEFNASTFTSRVIAGTGSDVYSAIIGAIGALRGPKHGGANE
CCHHHHHHHEEEEEEEEEECCCCCHHHHHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCC
VSLEIQQRYETPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQVIKRVAKQLSEEGGS
EEEEHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCC
LKMYHIADRLETVMWETKKMFPNLDWFSAVSYNMMGVPTEMFTPLFVIARVTGWAAHIIE
EEEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QRQDNKIIRPSANYTGPEDRPFVSIDDRC
HHCCCCEECCCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]