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The map label for this gene is lpxB [H]

Identifier: 16763619

GI number: 16763619

Start: 267783

End: 268931

Strand: Direct

Name: lpxB [H]

Synonym: STM0229

Alternate gene names: 16763619

Gene position: 267783-268931 (Clockwise)

Preceding gene: 16763618

Following gene: 16763620

Centisome position: 5.51

GC content: 55.7

Gene sequence:

>1149_bases
ATGGCGGCACAGCGTCCTTTAACGATTGCCCTGGTCGCCGGTGAAACGTCCGGCGATATTCTTGGCGCAGGCTTAATTCG
TGCGCTGAAAGCGCGCGTACCCAACGCCCGTTTTGTGGGCGTTGCGGGGCCGCGTATGCAGGCCGAAGGGTGTGAAGCCT
GGTACGAGATGGAAGAGCTGGCGGTCATGGGCATTGTTGAAGTGCTCGGACGTTTACGCCGTTTGTTGCATATCCGCGCC
GATCTGACCCGCCGTTTTACCGAACTCAAGCCCGATGTCTTTGTCGGGATTGATGCCCCTGATTTCAATATTACCCTCGA
AGGTAATCTGAAAAAAAAAGGGATTAAGACCATTCATTATGTCAGCCCGTCCGTTTGGGCCTGGCGACAGAAACGCGTTT
TCAAAATAGGCAGATCCACCCATATGGTGTTGGCTTTTCTGCCTTTCGAAAAAGCGTTTTACGATAAATTTAACGTCCCG
TGCCGCTTTATCGGTCACACCATGGCGGATGCCATGCCGCTGGACCCGGATAAAAATGCGGCGCGCGACGTGCTGGGTAT
CCCGCATGACGCCCATTGTCTGGCGCTACTGCCAGGCAGCCGTGGCGCGGAAGTGGAAATGCTCAGCGCCGATTTCCTGA
AAACCGCACAATTGCTGCGACAGCGCTATCCCGATCTGGAAGTGGTAGTGCCGCTGGTGAACGCGAAACGCCGCGAGCAG
TTTGAAAAAATTAAAGCGGAGGTTGCGCCGGATCTCGCCGTTCATTTGCTGGACGGCATGGCGCGCGAGGCGATGATCGC
CAGCGACGCGGCTCTGCTGGCCTCGGGTACGGCGGCACTGGAGTGTATGCTGGCAAAATGCCCGATGGTAGTGGGATATC
GTATGAAGCCCTTCACTTTCTGGCTGGCGAAACGTCTGGTGAAAACGGAGTATGTGTCTTTGCCTAACCTGCTGGCGGGA
AGAGAATTAGTCAAAGAGCTGTTGCAGGAAGAGTGCGAACCGCAAAAACTCGCCGAAGCGCTGTTGCCGCTACTGGCGAA
CGGTAAAACCAGCCATGCGATGCACGACACCTTCCGTGAATTGCATCAGCAGATCCGCTGTAATGCCGATGAGCAGGCGG
CAGATGCCGTCCTGGAGTTAGCACAATGA

Upstream 100 bases:

>100_bases
ACGAAGCGAAGCTGGAAATCGCTGAACTTGCTGAAAAGCATCCGGAAGTGAAGGCGTTTACCGAGTTCTTTGAGCGTTCA
ACGCGCGGTCCGATTCGTTA

Downstream 100 bases:

>100_bases
TCGAATTTGTTTATCCACACACCCATTTAGTGGCGGGTGTGGATGAAGTGGGCCGTGGCCCGCTGGTGGGCGCCGTAGTG
ACCGCCGCCGTGATCCTCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVP
CRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQ
FEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAG
RELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ

Sequences:

>Translated_382_residues
MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVP
CRFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQ
FEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAG
RELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ
>Mature_381_residues
AAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRAD
LTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHYVSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPC
RFIGHTMADAMPLDPDKNAARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQF
EKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTEYVSLPNLLAGR
ELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAADAVLELAQ

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=94.7643979057592, Blast_Score=730, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42452; Mature: 42321

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNA
CCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHH
ARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQ
HHHHHCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHH
FEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
LHQQIRCNADEQAADAVLELAQ
HHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AAQRPLTIALVAGETSGDILGAGLIRALKARVPNARFVGVAGPRMQAEGCEAWYEMEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTRRFTELKPDVFVGIDAPDFNITLEGNLKKKGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRSTHMVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKNA
CCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHH
ARDVLGIPHDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQRYPDLEVVVPLVNAKRREQ
HHHHHCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHH
FEKIKAEVAPDLAVHLLDGMAREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTEYVSLPNLLAGRELVKELLQEECEPQKLAEALLPLLANGKTSHAMHDTFRE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
LHQQIRCNADEQAADAVLELAQ
HHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA