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The map label for this gene is msrAB [H]

Identifier: 167623695

GI number: 167623695

Start: 2114372

End: 2115304

Strand: Direct

Name: msrAB [H]

Synonym: Shal_1765

Alternate gene names: 167623695

Gene position: 2114372-2115304 (Clockwise)

Preceding gene: 167623692

Following gene: 167623698

Centisome position: 40.45

GC content: 43.3

Gene sequence:

>933_bases
ATGAGGCTAGATAGAGATGTATATATGCGTAAATTAACAGAACTTGAAAAGCATGTAATAGAGCAAAAGGGGACCGAGCG
ACCATTTAGCGGTGAGTATTACCAACATGATGCACCGGGAGTATATTGCTGTAAAAAGTGCGATGCGCCCTTATATCGCT
CGGAAAGTAAGTTTAACGCCCATTGTGGCTGGCCAGCCTTTGATGATGAGATTGAAGGGGCGGTAAAGCGCAATATTGAT
GCAGACGGAATGCGAGTCGAAATTGTTTGCGCCCAGTGTGATGCTCATTTAGGTCATGTGTTTGAAGGGGAGATGTTGAC
GGCTAAAAATATCAGACACTGCGTCAATTCGGTCTCAATGGCTTTTAAATCAGCAGATGAACTTATAGATAAGTCCTCTG
GTACAGAGTTAGCCACTTTTGGCGGAGGCTGCTTTTGGTGCATAGAGGCTGTATTTTCAGCGATTAAGGGCGTAAGTAAA
GTGACTTCTGGTTATGCGGGAGGCACTGCTGATGATGCGAATTACAAAGCCGTGTGCAGCGGACAAACCGGTCATGCTGA
GGTGGTACAGATTGAATTTGATCCTAAAGAGGTCAGTTTTGAGCGCTTGCTTGAGGTATTTTGGCAAAGCCACGATCCTA
CAAGCTTAAATCGACAAGGTAACGATGTTGGTCCCCAATACCGTTCGGTGATCTTTATTCATGACGAGTCTCAAGCTCAA
GTCGCAAATAATATGATTGAGGACTTAACTAGAGTTGCAGCATGGCCTAATCCAATCGTGACTCAAGTTGTAGCTTACAA
CGGGTTTTTCGCTGCTGAAAATTACCATAACGATTATTTTGAATTAAATGGTGAGCAGCCATATTGTCAGATGGTCATAA
AACCTAAGGTAGATAAAGTAAAAGCCTTGTTCGCGGATAGATTGAAGAAATAA

Upstream 100 bases:

>100_bases
ATTATGATAAGTTTGCTAACCAACTTGAAAGCTTTTGCTAATCTGTAGGGTCTATTGACTGTTGACCCAGAACATAAGAG
GCCAATGAGGGATATTGGCA

Downstream 100 bases:

>100_bases
AAAGTTGAGCTAATAAAAAAGACGGGCAATGCCCGTCTTTTTCGTTTTTATCGCTTATGCTATTTGCGATTAGTCTGAAT
CGATTTACGAGTCGAGCTTA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRLDRDVYMRKLTELEKHVIEQKGTERPFSGEYYQHDAPGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIEGAVKRNID
ADGMRVEIVCAQCDAHLGHVFEGEMLTAKNIRHCVNSVSMAFKSADELIDKSSGTELATFGGGCFWCIEAVFSAIKGVSK
VTSGYAGGTADDANYKAVCSGQTGHAEVVQIEFDPKEVSFERLLEVFWQSHDPTSLNRQGNDVGPQYRSVIFIHDESQAQ
VANNMIEDLTRVAAWPNPIVTQVVAYNGFFAAENYHNDYFELNGEQPYCQMVIKPKVDKVKALFADRLKK

Sequences:

>Translated_310_residues
MRLDRDVYMRKLTELEKHVIEQKGTERPFSGEYYQHDAPGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIEGAVKRNID
ADGMRVEIVCAQCDAHLGHVFEGEMLTAKNIRHCVNSVSMAFKSADELIDKSSGTELATFGGGCFWCIEAVFSAIKGVSK
VTSGYAGGTADDANYKAVCSGQTGHAEVVQIEFDPKEVSFERLLEVFWQSHDPTSLNRQGNDVGPQYRSVIFIHDESQAQ
VANNMIEDLTRVAAWPNPIVTQVVAYNGFFAAENYHNDYFELNGEQPYCQMVIKPKVDKVKALFADRLKK
>Mature_310_residues
MRLDRDVYMRKLTELEKHVIEQKGTERPFSGEYYQHDAPGVYCCKKCDAPLYRSESKFNAHCGWPAFDDEIEGAVKRNID
ADGMRVEIVCAQCDAHLGHVFEGEMLTAKNIRHCVNSVSMAFKSADELIDKSSGTELATFGGGCFWCIEAVFSAIKGVSK
VTSGYAGGTADDANYKAVCSGQTGHAEVVQIEFDPKEVSFERLLEVFWQSHDPTSLNRQGNDVGPQYRSVIFIHDESQAQ
VANNMIEDLTRVAAWPNPIVTQVVAYNGFFAAENYHNDYFELNGEQPYCQMVIKPKVDKVKALFADRLKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=44.7368421052632, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=43.75, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI37620216, Length=134, Percent_Identity=43.2835820895522, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI301336164, Length=134, Percent_Identity=43.2835820895522, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI301336162, Length=134, Percent_Identity=43.2835820895522, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI73089054, Length=134, Percent_Identity=43.2835820895522, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI117606353, Length=133, Percent_Identity=39.0977443609023, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=43.2692307692308, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1790665, Length=174, Percent_Identity=38.5057471264368, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788077, Length=121, Percent_Identity=42.1487603305785, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=112, Percent_Identity=41.9642857142857, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115532676, Length=112, Percent_Identity=41.9642857142857, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=32.8767123287671, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=50, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=32.7160493827161, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=39.7260273972603, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645799, Length=129, Percent_Identity=42.6356589147287, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45553335, Length=129, Percent_Identity=42.6356589147287, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356369, Length=129, Percent_Identity=42.6356589147287, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=37.5757575757576, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=38.2978723404255, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645801, Length=140, Percent_Identity=39.2857142857143, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645804, Length=140, Percent_Identity=39.2857142857143, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221378664, Length=128, Percent_Identity=42.1875, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221378662, Length=135, Percent_Identity=40, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 34737; Mature: 34737

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDRDVYMRKLTELEKHVIEQKGTERPFSGEYYQHDAPGVYCCKKCDAPLYRSESKFNA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCC
HCGWPAFDDEIEGAVKRNIDADGMRVEIVCAQCDAHLGHVFEGEMLTAKNIRHCVNSVSM
CCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCHHCCCCCCCEECHHHHHHHHHHHHH
AFKSADELIDKSSGTELATFGGGCFWCIEAVFSAIKGVSKVTSGYAGGTADDANYKAVCS
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
GQTGHAEVVQIEFDPKEVSFERLLEVFWQSHDPTSLNRQGNDVGPQYRSVIFIHDESQAQ
CCCCCEEEEEEEECCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHH
VANNMIEDLTRVAAWPNPIVTQVVAYNGFFAAENYHNDYFELNGEQPYCQMVIKPKVDKV
HHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEEECCCHHHH
KALFADRLKK
HHHHHHHHCC
>Mature Secondary Structure
MRLDRDVYMRKLTELEKHVIEQKGTERPFSGEYYQHDAPGVYCCKKCDAPLYRSESKFNA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCC
HCGWPAFDDEIEGAVKRNIDADGMRVEIVCAQCDAHLGHVFEGEMLTAKNIRHCVNSVSM
CCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCHHCCCCCCCEECHHHHHHHHHHHHH
AFKSADELIDKSSGTELATFGGGCFWCIEAVFSAIKGVSKVTSGYAGGTADDANYKAVCS
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
GQTGHAEVVQIEFDPKEVSFERLLEVFWQSHDPTSLNRQGNDVGPQYRSVIFIHDESQAQ
CCCCCEEEEEEEECCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHH
VANNMIEDLTRVAAWPNPIVTQVVAYNGFFAAENYHNDYFELNGEQPYCQMVIKPKVDKV
HHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEEECCCHHHH
KALFADRLKK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]