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The map label for this gene is hemE [H]

Identifier: 167622424

GI number: 167622424

Start: 581451

End: 582515

Strand: Direct

Name: hemE [H]

Synonym: Shal_0484

Alternate gene names: 167622424

Gene position: 581451-582515 (Clockwise)

Preceding gene: 167622422

Following gene: 167622425

Centisome position: 11.12

GC content: 46.76

Gene sequence:

>1065_bases
ATGGCAGAATTAAAGAATGATCGTTATTTACGTGCGTTATTAAAACAGCCTGTCGACAGAACTCCTGTCTGGATGATGCG
TCAAGCAGGTCGTTATCTTCCAGAATATAAAGCCACCCGCGCAGAAGCTGGCGACTTCATGTCTCTTTGTAAGAACCAAG
ATTTAGCCTGTGAAGTGACTCTTCAGCCACTACGTCGCTATGATTTAGACGCAGCAATCCTGTTCTCTGATATTCTTACA
GTGCCAGATGCAATGGGCTTAGGCCTGTACTTCGAAACTGGTGAAGGCCCACGTTTTGAACGTCCTACAGACACCATCGA
TTCAATCAAAAAGCTTTGCATCCCAGATCCAGAAGATGAGCTTGGCTACGTAATGCGTGCTGTAAGCACTATTCGTCGTG
AGCTTAAAGGTGAAGTACCATTAATTGGTTTCTCTGGTTCACCTTGGACACTAGCGACTTACATGGTTGAAGGCGGTTCT
AGTAAGGCGTTTGAAAAGATTAAGAAGATGGCTTACGAAGAGCCAGCAACTTTGCATATGCTGCTTGATAAGCTAGCAGA
CTCTGTGACGCTATACCTGAATGCTCAGGTTGCTAACGGTGCACAATCTCTTATGATCTTCGATTCATGGGGTGGTGCGC
TTTCTCACCACGCATACCGTGAATTCTCACTACGTTACATGCAGAAAATCGTTGATGGCCTAACTCGCCATGCAGACGGT
CGCCAAGTACCAGTGACTCTGTTCACTAAAGGTGGCGGACTATGGCTTGAGTCTATGGCTGAAACTGGCTGTGACGCACT
AGGTCTAGACTGGACTGTTGATATCGGTGATGCACGTCGCCGTGTTGGTCATAAAGTTGCCCTACAAGGTAACATGGACC
CATCAGTACTTTACGGTACACCAGAGCGCATTCATCAAGAAGTGGATCAAATCCTGTCTTCTTATGGTGAAGGTACTGGC
CATGTATTTAACTTGGGCCACGGTATTCACCAGCACGTTGATCCTGAGCGCGCGGGCTCGTTTATCAACTCAGTACATGA
GCTATCGGCTAAGTACCACAAGTAA

Upstream 100 bases:

>100_bases
TATCTGTCACATTATTTTACGGATTCAGGTTACTTTATTAACGTAAATGCTAAACTACTGCCCCAAGCGGATATCACTAT
AAGTTTAGGAATCAAGCCAA

Downstream 100 bases:

>100_bases
TCAACTAGCATAAACGCTAAGCGATTAAATAAAGGCTCAGTTTACTGGGCCTTTATTGTTTCTGTGGTTTAGCAAAGTCG
TTTCAGCTGGATACCGCTTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFETGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILSSYGEGTG
HVFNLGHGIHQHVDPERAGSFINSVHELSAKYHK

Sequences:

>Translated_354_residues
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILT
VPDAMGLGLYFETGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILSSYGEGTG
HVFNLGHGIHQHVDPERAGSFINSVHELSAKYHK
>Mature_353_residues
AELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVTLQPLRRYDLDAAILFSDILTV
PDAMGLGLYFETGEGPRFERPTDTIDSIKKLCIPDPEDELGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFEKIKKMAYEEPATLHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADGR
QVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGTPERIHQEVDQILSSYGEGTGH
VFNLGHGIHQHVDPERAGSFINSVHELSAKYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=47.0254957507082, Blast_Score=316, Evalue=2e-86,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=77.9661016949153, Blast_Score=576, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=39.6067415730337, Blast_Score=274, Evalue=1e-74,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.0749279538905, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.0749279538905, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39525; Mature: 39393

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFETGEGPRFERPTDTIDSIKKLCIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKKMAYEEPATLHM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGT
CCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCEEEEECCCCCCEEECC
PERIHQEVDQILSSYGEGTGHVFNLGHGIHQHVDPERAGSFINSVHELSAKYHK
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AELKNDRYLRALLKQPVDRTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNQDLACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LQPLRRYDLDAAILFSDILTVPDAMGLGLYFETGEGPRFERPTDTIDSIKKLCIPDPEDE
HHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMRAVSTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFEKIKKMAYEEPATLHM
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHHAYREFSLRYMQKIVDGLTRHADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RQVPVTLFTKGGGLWLESMAETGCDALGLDWTVDIGDARRRVGHKVALQGNMDPSVLYGT
CCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCEEEEECCCCCCEEECC
PERIHQEVDQILSSYGEGTGHVFNLGHGIHQHVDPERAGSFINSVHELSAKYHK
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA