Click here to switch to the map view.

The map label for this gene is murC

Identifier: 167622396

GI number: 167622396

Start: 535348

End: 536817

Strand: Direct

Name: murC

Synonym: Shal_0456

Alternate gene names: 167622396

Gene position: 535348-536817 (Clockwise)

Preceding gene: 167622395

Following gene: 167622397

Centisome position: 10.24

GC content: 48.64

Gene sequence:

>1470_bases
ATGAGTAACAAAGCAGAGAAGTATTCGCAGCTAAGATCCATGATCCCTGAAATGCGCAGGGTTAAGCACATCTATTTCGT
TGGAATAGGTGGTGCGGGCATGGGTGGCATAGCGGAAGTGCTTGTTAATGAAGGTTACAAGTTAAGTGGTTCAGATATCG
CTGAAAGTGCGGTAACTCAGCGATTAGCTCAACTTGGCGCGACAATTTATATTGGCCATGATGCAAGCCAAGTGAAAGGT
ATGGATGTAGTGGTTGTGTCAACCGCTATCAGTGCTGACAACCCAGAATTAGTTGCAGCAAAAGAACTTAGGATCCCCGT
GGTACGCCGTGCCGAAATGTTAGCCGAGCTGATGCGTTATCGCCATGGTGTCGCTGTTGCGGGTACCCACGGTAAGACCA
CTACCACGAGTTTGATCGCTAGCATTTATGGCGAAGCAGAGCGCGACCCTACCTTCGTGATCGGGGGCTTGCTCAATAGT
GCAGGCACCAACGCTAGATTAGGCCATAGCCGCTATCTTATTGCAGAAGCGGATGAGAGTGATGCGAGCTTCTTGCATCT
TCAGCCGATGGTGAGTGTGGTGACCAATATCGAAGCTGACCATATGGACACCTATGAAGGCGATCTAGAGAAGCTTAAAA
CCACTTTTGTCGACTTCCTGCATAACTTGCCTTTCTATGGGGTTGCCGTCGTCTGTATCGACGATCCTATTGTGCGTGAG
CTTATTCCACGTATTGGTCGTCGCATCGTGACTTATGGTTTTAGCGATGACGCGGATGTACAGGCGCTAGATTTTAAACA
AACGGGTTATAGCTGTGAGTTCACGGTTAAGCGTGCAGGGCTAGCTGATTTGCGCTTATCAGTTAACTTACCGGGTGAGC
ATAATGTGTTAAATGCGCTGGCTGCTATTGCCGTTGCGACTGAAGATGATATTGAAGATGCAGCCATCATTAAAGCGCTA
GCCGAGTTTCAAGGTATTGGACGACGCTTCCAACAAATTGGTGAGTTCGCGACAAGCAAAGGCGAGATTAAATTGGTCGA
TGACTATGGTCATCATCCGAGTGAAGTGGCTGCAACGATTAAGGCTGCCAGACTTGGTTGGCCTGAGCGTCGTCTGGTGA
TGATCTACCAGCCACATCGCTACAGTCGTACCCGCGACCTGTATGAAGACTTCGTAGAGGTCTTATCGCAAGTAGACTGC
CTATTAATGTTAGATGTATACGCCGCGGGTGAAGCGCCAATTCCTGGTGCCGATAGTCGCGCCCTATGCCGCTCGATTAG
AGTTCGTGGTCAGGTTGAGCCGGTGTTTGTAGCGAGCACTGAGCAGCTAGAAACTATCTTGCCAGAGATATTGCAAGGCG
GTGACTTACTGTTGACTCAAGGGGCTGGCAGTATTGGATTGTTATCACGTAGTCTTACCGAATCTAATCTAGGTTTTGCT
GCTACGGGTAAAGATGAAAAAAATGCGTAA

Upstream 100 bases:

>100_bases
GAATTATGCAATATGGGCCAGCGTGCTCGAGACGTAGCAATCTTAGATGCAACTCAAAGAGTTGCCAACGTCTGCATTCG
TTTAGCTGAAAAGGGTTGAG

Downstream 100 bases:

>100_bases
CTTAGCGTTAGATAAGTTAAGTTACACATCAAATTTTGACGCTTGGGATAAGGGCTATATAATGGCCGGTTTTCTGGGGT
TACGGTTGCAAAAGGAAGCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSNKAEKYSQLRSMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAESAVTQRLAQLGATIYIGHDASQVKG
MDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGEAERDPTFVIGGLLNS
AGTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
LIPRIGRRIVTYGFSDDADVQALDFKQTGYSCEFTVKRAGLADLRLSVNLPGEHNVLNALAAIAVATEDDIEDAAIIKAL
AEFQGIGRRFQQIGEFATSKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDC
LLMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETILPEILQGGDLLLTQGAGSIGLLSRSLTESNLGFA
ATGKDEKNA

Sequences:

>Translated_489_residues
MSNKAEKYSQLRSMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAESAVTQRLAQLGATIYIGHDASQVKG
MDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGEAERDPTFVIGGLLNS
AGTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
LIPRIGRRIVTYGFSDDADVQALDFKQTGYSCEFTVKRAGLADLRLSVNLPGEHNVLNALAAIAVATEDDIEDAAIIKAL
AEFQGIGRRFQQIGEFATSKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDC
LLMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETILPEILQGGDLLLTQGAGSIGLLSRSLTESNLGFA
ATGKDEKNA
>Mature_488_residues
SNKAEKYSQLRSMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAESAVTQRLAQLGATIYIGHDASQVKGM
DVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASIYGEAERDPTFVIGGLLNSA
GTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVREL
IPRIGRRIVTYGFSDDADVQALDFKQTGYSCEFTVKRAGLADLRLSVNLPGEHNVLNALAAIAVATEDDIEDAAIIKALA
EFQGIGRRFQQIGEFATSKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCL
LMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETILPEILQGGDLLLTQGAGSIGLLSRSLTESNLGFAA
TGKDEKNA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=64.509394572025, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=26.8817204301075, Blast_Score=141, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SHEHH (B0TQN8)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672690.1
- ProteinModelPortal:   B0TQN8
- SMR:   B0TQN8
- GeneID:   5906551
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0456
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   SHAL458817:SHAL_0456-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53125; Mature: 52994

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKAEKYSQLRSMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAESAVTQ
CCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHH
RLAQLGATIYIGHDASQVKGMDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRY
HHHHCCCEEEECCCHHHCCCCEEEEEEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHH
RHGVAVAGTHGKTTTTSLIASIYGEAERDPTFVIGGLLNSAGTNARLGHSRYLIAEADES
HCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCCC
DASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
CCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHH
LIPRIGRRIVTYGFSDDADVQALDFKQTGYSCEFTVKRAGLADLRLSVNLPGEHNVLNAL
HHHHHCCEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHH
AAIAVATEDDIEDAAIIKALAEFQGIGRRFQQIGEFATSKGEIKLVDDYGHHPSEVAATI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
KAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCLLMLDVYAAGEAPIPGADSR
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCCHH
ALCRSIRVRGQVEPVFVASTEQLETILPEILQGGDLLLTQGAGSIGLLSRSLTESNLGFA
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEE
ATGKDEKNA
ECCCCCCCC
>Mature Secondary Structure 
SNKAEKYSQLRSMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAESAVTQ
CCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHHH
RLAQLGATIYIGHDASQVKGMDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRY
HHHHCCCEEEECCCHHHCCCCEEEEEEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHH
RHGVAVAGTHGKTTTTSLIASIYGEAERDPTFVIGGLLNSAGTNARLGHSRYLIAEADES
HCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCCC
DASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
CCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHH
LIPRIGRRIVTYGFSDDADVQALDFKQTGYSCEFTVKRAGLADLRLSVNLPGEHNVLNAL
HHHHHCCEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHH
AAIAVATEDDIEDAAIIKALAEFQGIGRRFQQIGEFATSKGEIKLVDDYGHHPSEVAATI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
KAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCLLMLDVYAAGEAPIPGADSR
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCCHH
ALCRSIRVRGQVEPVFVASTEQLETILPEILQGGDLLLTQGAGSIGLLSRSLTESNLGFA
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEE
ATGKDEKNA
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA