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The map label for this gene is gor [H]

Identifier: 167622131

GI number: 167622131

Start: 224775

End: 226130

Strand: Reverse

Name: gor [H]

Synonym: Shal_0190

Alternate gene names: 167622131

Gene position: 226130-224775 (Counterclockwise)

Preceding gene: 167622132

Following gene: 167622128

Centisome position: 4.33

GC content: 51.18

Gene sequence:

>1356_bases
ATGGCTCAACATTTTGATTATATCTGCCTTGGTGCAGGTAGTGGCGGTATTGCATCGGCTAACAGAGCCGCCATGCGCGG
CGCAAAAGTGCTACTTATCGAAGCAAAAGAGCTAGGTGGCACCTGTGTAAATGTAGGTTGCGTACCGAAAAAGGTGATGT
GGTATGGCGCTCAGGTTGCCGAAGCTATGCACCTTTACGCTAAAGATTATGGTTTCGACGTGACCGTGAATAAGTTTGAC
TGGAGCACCCTTGTTGCCAGTCGCGAAGCCTATATCGACCGTATCCACGGCTCATATGATCGCGGCCTAGAGAGCAATGG
CGTTACCCTTGTTCGTGGTTACGGTCGTTTTGTCGACAGCAGCACCATCGAAGTGAATGGCGAGCACTACAGCGCCGACA
ATATCTTGATCGCCACAGGCGGCGCAGCCACCATTCCAAATATTCCTGGCGCCGAGCACGGTATCGACTCAGATGGTTTC
TTCGCATTAGCCGAGCAACCAAAACGCGTTGCGGTGATTGGTGCAGGCTACATTGCCGTTGAAGTGGCTGGCGTACTGCA
AGCTCTAGGTAGCGATACTCACCTGTTTGTGCGTAAGCACGCCCCACTACGTAACTTTGACCCTATGCTAAGTGAAGCGC
TGATGGAGTCTATGGCCACTGACGGCCCTACGCTGCATACTCACAGTGTGCCTGAGTCGGTCACCAAAAACAGTGATGGT
AGCTTAACCCTTAAAATTGAAAATGGCGAAAGCTATGATATCGACTGCCTGATCTGGGCTATTGGTCGTCAGCCATCAAC
AGCAAACATCGGCCTTGAAAACACCAAGGTTAAGCTAGACGAAAAAGGCTATGTGATCACCGATGAGCAGCAAAATACCA
CGGACACGGGCATTTACTGTGTTGGTGATATCATGGCGGGCGGCGTAGAGCTAACGCCTGTCGCAGTTAAAGCGGGCCGT
TTACTGTCAGAGCGCCTATTTAACGGCATGACAGACGCCAAGATGGATTACAGCTGCATTCCAACTGTCGTATTTAGCCA
CCCAGCCATCGGCACCATGGGGTTAACCGAGCCTGAAGCCAAGGCTGAGTACGGCGAAGATAACGTGACGGTATACACCT
CAGGCTTCACCTCTATGTACACAGCAGTAACCGCTCATCGTCAGGCTTGTAAGATGAAACTAATCTGCGCCGGCGATAAC
CAGAAGGTCGTGGGTATTCACGGCATAGGTTACGGTATGGATGAAATTCTACAAGGCTTCGGCGTAGCGATGAAGATGGG
CGCAACTAAGGCAGATTTCGATGCGGTTGTGGCTATCCACCCAACTGGATCTGAGGAATTTGTCACCATGAGGTAA

Upstream 100 bases:

>100_bases
GCTTTTTGATCTAACAAGCGTATTAATGATAATTACAGGTACGAAGGCCCATATTCGTTTGCTTTTGTCCATCGGTTCGC
AACTTTTATTGGAGATACAC

Downstream 100 bases:

>100_bases
TTAGTTGATTACAAATAAAAAAGCCGCTTATTAAGCGGCTTTTTTGTATCTAAAACTTAAGGTCATATGTCAGTAAATCC
TTTTACTGACATAGAGCTAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFD
WSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSSTIEVNGEHYSADNILIATGGAATIPNIPGAEHGIDSDGF
FALAEQPKRVAVIGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSVPESVTKNSDG
SLTLKIENGESYDIDCLIWAIGRQPSTANIGLENTKVKLDEKGYVITDEQQNTTDTGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSCIPTVVFSHPAIGTMGLTEPEAKAEYGEDNVTVYTSGFTSMYTAVTAHRQACKMKLICAGDN
QKVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFD
WSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSSTIEVNGEHYSADNILIATGGAATIPNIPGAEHGIDSDGF
FALAEQPKRVAVIGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSVPESVTKNSDG
SLTLKIENGESYDIDCLIWAIGRQPSTANIGLENTKVKLDEKGYVITDEQQNTTDTGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSCIPTVVFSHPAIGTMGLTEPEAKAEYGEDNVTVYTSGFTSMYTAVTAHRQACKMKLICAGDN
QKVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGSEEFVTMR
>Mature_450_residues
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFDW
STLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSSTIEVNGEHYSADNILIATGGAATIPNIPGAEHGIDSDGFF
ALAEQPKRVAVIGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSVPESVTKNSDGS
LTLKIENGESYDIDCLIWAIGRQPSTANIGLENTKVKLDEKGYVITDEQQNTTDTGIYCVGDIMAGGVELTPVAVKAGRL
LSERLFNGMTDAKMDYSCIPTVVFSHPAIGTMGLTEPEAKAEYGEDNVTVYTSGFTSMYTAVTAHRQACKMKLICAGDNQ
KVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=50.4347826086956, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=35.9477124183007, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI148277065, Length=432, Percent_Identity=37.5, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI148277071, Length=432, Percent_Identity=37.5, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI33519430, Length=432, Percent_Identity=37.5, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI33519428, Length=432, Percent_Identity=37.5, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI33519426, Length=432, Percent_Identity=37.5, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=33.4061135371179, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI291045268, Length=458, Percent_Identity=30.1310043668122, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=30.2832244008715, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=67.1840354767184, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=28.0701754385965, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87082354, Length=436, Percent_Identity=25, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=23.1788079470199, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1787114, Length=363, Percent_Identity=26.7217630853994, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=55.6541019955654, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=55.6541019955654, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.5932203389831, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71982272, Length=439, Percent_Identity=34.1685649202733, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=28.7878787878788, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17559934, Length=194, Percent_Identity=24.2268041237113, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=49.3562231759657, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.755364806867, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=23.7687366167024, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=37.791932059448, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=37.791932059448, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=37.791932059448, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=36.0759493670886, Blast_Score=248, Evalue=8e-66,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=28.8840262582057, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48167; Mature: 48036

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVA
CCCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVTVNKFDWSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEECCCCCCC
STIEVNGEHYSADNILIATGGAATIPNIPGAEHGIDSDGFFALAEQPKRVAVIGAGYIAV
CEEEECCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSVPESVTKNSDG
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCCC
SLTLKIENGESYDIDCLIWAIGRQPSTANIGLENTKVKLDEKGYVITDEQQNTTDTGIYC
EEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSCIPTVVFSHPAIGTMGLTEPEA
EEEHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHH
KAEYGEDNVTVYTSGFTSMYTAVTAHRQACKMKLICAGDNQKVVGIHGIGYGMDEILQGF
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGSEEFVTMR
CCEEECCCCCCCCEEEEEEECCCCCCEEEEC
>Mature Secondary Structure 
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVA
CCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVTVNKFDWSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEECCCCCCC
STIEVNGEHYSADNILIATGGAATIPNIPGAEHGIDSDGFFALAEQPKRVAVIGAGYIAV
CEEEECCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSVPESVTKNSDG
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCCC
SLTLKIENGESYDIDCLIWAIGRQPSTANIGLENTKVKLDEKGYVITDEQQNTTDTGIYC
EEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSCIPTVVFSHPAIGTMGLTEPEA
EEEHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHH
KAEYGEDNVTVYTSGFTSMYTAVTAHRQACKMKLICAGDNQKVVGIHGIGYGMDEILQGF
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGSEEFVTMR
CCEEECCCCCCCCEEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]