Click here to switch to the map view.

The map label for this gene is mutS2 [H]

Identifier: 167040669

GI number: 167040669

Start: 2055837

End: 2058212

Strand: Reverse

Name: mutS2 [H]

Synonym: Teth514_2046

Alternate gene names: 167040669

Gene position: 2058212-2055837 (Counterclockwise)

Preceding gene: 167040670

Following gene: 167040668

Centisome position: 83.76

GC content: 33.29

Gene sequence:

>2376_bases
ATGGTGAGGGGAATTAATAGTAGAGCAATAAAAAGTCTTGAATTTGACAAGATAGTGGAGTTTATTGTTGGCTATTGTGA
TTCGGATTTAGGCAAACAAAAAGCTTTAGATATTGTCATAAAAAAAGACATAGAGGAAATAGAGAGGGAATTAGATTTAC
TGAATGAGGCAATTAGCTTTATTTCCTCCTATGGAGGTATTTCTTTTGCTTTTGAGGACATAAGGGATTATATAAAAAAA
GCACAAATAGATTCCGTGCTTTATAACCAAGAGCTTTTAAAGATAAAGAAATTTCTTAACTTGGTAAGCCAAATAAAAGG
CTATTTTAAAAATCTTCAAGAAAGTGATAGATTTGTAAGGTTAAAAGAATATGATAAAAAAGTCTTACCGATAAAAAATT
TGGAAAAAAGGATTGAAAATATAATAATTTCAGAAGATGAAATAGCAGATGATGCTTCTCCAATGCTTAAAGCTTTAAGA
AGGCAGAAATTGAGCATAAATGAAAAAATAAGGGCGACATTGAATTCAATAATTTCTACACGTCAAAAAGAATTGCAAGA
GCCTATTATAACTGTAAGACAGGGAAGATACGTTGTACCTGTAAAACAAGAATATCGCAGCACTTTTAAAGGTATCGTCC
ACGACCAATCCTCCAGTGGTGCTACTCTTTTTATTGAACCTATGCAAGTGGTTGACTTAAACAACGAATTGAGACAAGTG
GAATTAAAAGAGAAGCAGGAGATACAGAGAATACTTTTTGAACTTTCTCAAGAGGTCAAAAAGTATTCACAAATTTTATT
TAATGACATTGAAATAGTTTCAGAATTAGATTTTATATTTGCTAAGGCTAAATATTCTTTAAAGCTAAAAGCTGTAAGGC
CAGAGCTAAACACAATGGGATATATTAATTTAAAAAAAGCAAGGCATCCTCTCATAAATCAGGAAGTAGTTGTTCCTATA
GATATACATATAGGAAAGCAATTTAATACTTTAGTCATTACTGGTCCTAATACCGGTGGGAAAACTGTAACTTTAAAAAC
AGTGGGACTTTTAACTTTAATGGCAATGGCGGGGCTTAATATTCCTGCGGAAGAAAAGTCACAGGTTTCAATATTTGAGG
AAGTTTTTGTGGATATAGGAGATGAGCAGAGTATTGAACAAAGCTTAAGCACTTTTTCTTCTCATATGACGAATATTGTA
AGTATACTCCAAAAAGTAAACAAAAATTGCCTTGTTTTGTTAGATGAATTAGGGGCAGGTACAGATCCTATAGAAGGTGC
TGCTTTGGCTATGAGTATTCTCGATACCTTGCATAAGATTGGTGCGAAGACAATAGCCACTACTCATTATAGTGAGCTAA
AGCAGTATGCCTTAAAAATTCCAGGAGTAGAAAATGCCAGTGTGGAATTTGATGTTGAAACTTTAAAGCCTACTTATAAA
CTTATAATAAGCCTTCCTGGCAAAAGCAATGCCTTTGAAATATCTAAAAGATTGGGACTTCCTCAGCAAATAATAGAAAA
TGCGAGAAAGTATATTTCAGGAGAAGCTTTAAAATTTGAAGACATAATTGCAGACGTCGAAAGTAAACGAAGGGAATTGG
AAAAGGCAAATCACGAAATAGCTTTTTTAAAGAAAGATGTGGAAATTTTAAAAGAGGAATTAGAAAAAGAAAAGAAAAAA
TTGCAAAGTGAAAGGGATAAAATATTAAAAGAGGCGAAAGAAAAGGCGAGGAAAATAATACAAGAAGCGAAATTTACTGC
TGAAGAAATAATCAAAAAGATAAGAGAGGCAGAAGAAAGCACACAAAATAAAGACAGGATAATACAAGAAGTAAGAGAAG
AATTAAAGAAAAATTTAGAAGAATTAGAAGAAGAAGTTTTAAAGCCTAAAGAGGCTCACTACAGCAGAATCCCTGATAAT
TTAAAAGAGGGACAGACAGTCTATATAGTACCTTTGGACCAAAATGGGATTGTACTTTCTCTTCCTGACAAATCGGGAAA
TGTAGAAGTGCAGGCAGGAATTTTAAAGATGACAGTTCATATAAGTAATTTGAGGGTAGCAGAGGAGAAAGAAGAGGAGG
AAGTAAAAAAAGGCTACAGCAAATTTGTACACGAAAAGTCTCAATCTATAAGCACTTCCATAGATGTAAGAGGTAAAAAC
CTTGACGATGCTTTATTAGAGGTGGAAAAATATATAGACGATGCTTATTTAGCTGGACTTAAGGAGGTGACAATTATTCA
CGGACGTGGTACAGGGGTGTTAAGGACAGGGATATCACAATTTTTAAGAAGCAATAAGCATGTTAAATCTTTTAGATTAG
GTAAATACGGTGAAGGAGGAGACGGTGTTACAATAGTAGAATTAGCCAATAAATAG

Upstream 100 bases:

>100_bases
AGAAAGTTTTAAAAATGCATATTGAAGCTTTAAAAGGGAATGAAATTGAAATTTTAGAAGGAAAATATACAAAAGGACAT
TTTTACAGAGGAGTTTTGTG

Downstream 100 bases:

>100_bases
GGGATGGTAAAATGTATTTGGTAAGTGCTTGTCTTGCCGGAGTTAACTGTAAATACGATGAAGGAAACAATGAAAAAGAA
GAAATAAAAAAATTAGTAGA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MVRGINSRAIKSLEFDKIVEFIVGYCDSDLGKQKALDIVIKKDIEEIERELDLLNEAISFISSYGGISFAFEDIRDYIKK
AQIDSVLYNQELLKIKKFLNLVSQIKGYFKNLQESDRFVRLKEYDKKVLPIKNLEKRIENIIISEDEIADDASPMLKALR
RQKLSINEKIRATLNSIISTRQKELQEPIITVRQGRYVVPVKQEYRSTFKGIVHDQSSSGATLFIEPMQVVDLNNELRQV
ELKEKQEIQRILFELSQEVKKYSQILFNDIEIVSELDFIFAKAKYSLKLKAVRPELNTMGYINLKKARHPLINQEVVVPI
DIHIGKQFNTLVITGPNTGGKTVTLKTVGLLTLMAMAGLNIPAEEKSQVSIFEEVFVDIGDEQSIEQSLSTFSSHMTNIV
SILQKVNKNCLVLLDELGAGTDPIEGAALAMSILDTLHKIGAKTIATTHYSELKQYALKIPGVENASVEFDVETLKPTYK
LIISLPGKSNAFEISKRLGLPQQIIENARKYISGEALKFEDIIADVESKRRELEKANHEIAFLKKDVEILKEELEKEKKK
LQSERDKILKEAKEKARKIIQEAKFTAEEIIKKIREAEESTQNKDRIIQEVREELKKNLEELEEEVLKPKEAHYSRIPDN
LKEGQTVYIVPLDQNGIVLSLPDKSGNVEVQAGILKMTVHISNLRVAEEKEEEEVKKGYSKFVHEKSQSISTSIDVRGKN
LDDALLEVEKYIDDAYLAGLKEVTIIHGRGTGVLRTGISQFLRSNKHVKSFRLGKYGEGGDGVTIVELANK

Sequences:

>Translated_791_residues
MVRGINSRAIKSLEFDKIVEFIVGYCDSDLGKQKALDIVIKKDIEEIERELDLLNEAISFISSYGGISFAFEDIRDYIKK
AQIDSVLYNQELLKIKKFLNLVSQIKGYFKNLQESDRFVRLKEYDKKVLPIKNLEKRIENIIISEDEIADDASPMLKALR
RQKLSINEKIRATLNSIISTRQKELQEPIITVRQGRYVVPVKQEYRSTFKGIVHDQSSSGATLFIEPMQVVDLNNELRQV
ELKEKQEIQRILFELSQEVKKYSQILFNDIEIVSELDFIFAKAKYSLKLKAVRPELNTMGYINLKKARHPLINQEVVVPI
DIHIGKQFNTLVITGPNTGGKTVTLKTVGLLTLMAMAGLNIPAEEKSQVSIFEEVFVDIGDEQSIEQSLSTFSSHMTNIV
SILQKVNKNCLVLLDELGAGTDPIEGAALAMSILDTLHKIGAKTIATTHYSELKQYALKIPGVENASVEFDVETLKPTYK
LIISLPGKSNAFEISKRLGLPQQIIENARKYISGEALKFEDIIADVESKRRELEKANHEIAFLKKDVEILKEELEKEKKK
LQSERDKILKEAKEKARKIIQEAKFTAEEIIKKIREAEESTQNKDRIIQEVREELKKNLEELEEEVLKPKEAHYSRIPDN
LKEGQTVYIVPLDQNGIVLSLPDKSGNVEVQAGILKMTVHISNLRVAEEKEEEEVKKGYSKFVHEKSQSISTSIDVRGKN
LDDALLEVEKYIDDAYLAGLKEVTIIHGRGTGVLRTGISQFLRSNKHVKSFRLGKYGEGGDGVTIVELANK
>Mature_791_residues
MVRGINSRAIKSLEFDKIVEFIVGYCDSDLGKQKALDIVIKKDIEEIERELDLLNEAISFISSYGGISFAFEDIRDYIKK
AQIDSVLYNQELLKIKKFLNLVSQIKGYFKNLQESDRFVRLKEYDKKVLPIKNLEKRIENIIISEDEIADDASPMLKALR
RQKLSINEKIRATLNSIISTRQKELQEPIITVRQGRYVVPVKQEYRSTFKGIVHDQSSSGATLFIEPMQVVDLNNELRQV
ELKEKQEIQRILFELSQEVKKYSQILFNDIEIVSELDFIFAKAKYSLKLKAVRPELNTMGYINLKKARHPLINQEVVVPI
DIHIGKQFNTLVITGPNTGGKTVTLKTVGLLTLMAMAGLNIPAEEKSQVSIFEEVFVDIGDEQSIEQSLSTFSSHMTNIV
SILQKVNKNCLVLLDELGAGTDPIEGAALAMSILDTLHKIGAKTIATTHYSELKQYALKIPGVENASVEFDVETLKPTYK
LIISLPGKSNAFEISKRLGLPQQIIENARKYISGEALKFEDIIADVESKRRELEKANHEIAFLKKDVEILKEELEKEKKK
LQSERDKILKEAKEKARKIIQEAKFTAEEIIKKIREAEESTQNKDRIIQEVREELKKNLEELEEEVLKPKEAHYSRIPDN
LKEGQTVYIVPLDQNGIVLSLPDKSGNVEVQAGILKMTVHISNLRVAEEKEEEEVKKGYSKFVHEKSQSISTSIDVRGKN
LDDALLEVEKYIDDAYLAGLKEVTIIHGRGTGVLRTGISQFLRSNKHVKSFRLGKYGEGGDGVTIVELANK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=375, Percent_Identity=28, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI4557761, Length=341, Percent_Identity=28.7390029325513, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI36949366, Length=248, Percent_Identity=32.258064516129, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI284813531, Length=311, Percent_Identity=28.6173633440514, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI26638666, Length=335, Percent_Identity=26.865671641791, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4505253, Length=335, Percent_Identity=26.865671641791, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI26638664, Length=336, Percent_Identity=27.0833333333333, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI262231786, Length=209, Percent_Identity=31.1004784688995, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1789089, Length=246, Percent_Identity=30.4878048780488, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17508445, Length=360, Percent_Identity=25.2777777777778, Blast_Score=120, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17534743, Length=375, Percent_Identity=26.6666666666667, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17508447, Length=270, Percent_Identity=25.5555555555556, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=291, Percent_Identity=22.680412371134, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=383, Percent_Identity=25.8485639686684, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319935, Length=303, Percent_Identity=32.3432343234323, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321912, Length=323, Percent_Identity=24.4582043343653, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=297, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321109, Length=234, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=248, Percent_Identity=27.0161290322581, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24664545, Length=282, Percent_Identity=30.1418439716312, Blast_Score=119, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24584320, Length=260, Percent_Identity=28.8461538461538, Blast_Score=102, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89754; Mature: 89754

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRGINSRAIKSLEFDKIVEFIVGYCDSDLGKQKALDIVIKKDIEEIERELDLLNEAISF
CCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISSYGGISFAFEDIRDYIKKAQIDSVLYNQELLKIKKFLNLVSQIKGYFKNLQESDRFVR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKEYDKKVLPIKNLEKRIENIIISEDEIADDASPMLKALRRQKLSINEKIRATLNSIIST
HHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RQKELQEPIITVRQGRYVVPVKQEYRSTFKGIVHDQSSSGATLFIEPMQVVDLNNELRQV
HHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEECCHHEECCCHHHHHH
ELKEKQEIQRILFELSQEVKKYSQILFNDIEIVSELDFIFAKAKYSLKLKAVRPELNTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCC
YINLKKARHPLINQEVVVPIDIHIGKQFNTLVITGPNTGGKTVTLKTVGLLTLMAMAGLN
EEEEHHHCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHCCC
IPAEEKSQVSIFEEVFVDIGDEQSIEQSLSTFSSHMTNIVSILQKVNKNCLVLLDELGAG
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCC
TDPIEGAALAMSILDTLHKIGAKTIATTHYSELKQYALKIPGVENASVEFDVETLKPTYK
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHCCEEE
LIISLPGKSNAFEISKRLGLPQQIIENARKYISGEALKFEDIIADVESKRRELEKANHEI
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCHH
AFLKKDVEILKEELEKEKKKLQSERDKILKEAKEKARKIIQEAKFTAEEIIKKIREAEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TQNKDRIIQEVREELKKNLEELEEEVLKPKEAHYSRIPDNLKEGQTVYIVPLDQNGIVLS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCEEEEEEECCCCEEEE
LPDKSGNVEVQAGILKMTVHISNLRVAEEKEEEEVKKGYSKFVHEKSQSISTSIDVRGKN
CCCCCCCEEEEECEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LDDALLEVEKYIDDAYLAGLKEVTIIHGRGTGVLRTGISQFLRSNKHVKSFRLGKYGEGG
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
DGVTIVELANK
CCEEEEEECCC
>Mature Secondary Structure
MVRGINSRAIKSLEFDKIVEFIVGYCDSDLGKQKALDIVIKKDIEEIERELDLLNEAISF
CCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISSYGGISFAFEDIRDYIKKAQIDSVLYNQELLKIKKFLNLVSQIKGYFKNLQESDRFVR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKEYDKKVLPIKNLEKRIENIIISEDEIADDASPMLKALRRQKLSINEKIRATLNSIIST
HHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RQKELQEPIITVRQGRYVVPVKQEYRSTFKGIVHDQSSSGATLFIEPMQVVDLNNELRQV
HHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEECCHHEECCCHHHHHH
ELKEKQEIQRILFELSQEVKKYSQILFNDIEIVSELDFIFAKAKYSLKLKAVRPELNTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCC
YINLKKARHPLINQEVVVPIDIHIGKQFNTLVITGPNTGGKTVTLKTVGLLTLMAMAGLN
EEEEHHHCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHCCC
IPAEEKSQVSIFEEVFVDIGDEQSIEQSLSTFSSHMTNIVSILQKVNKNCLVLLDELGAG
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCC
TDPIEGAALAMSILDTLHKIGAKTIATTHYSELKQYALKIPGVENASVEFDVETLKPTYK
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHCCEEE
LIISLPGKSNAFEISKRLGLPQQIIENARKYISGEALKFEDIIADVESKRRELEKANHEI
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCHH
AFLKKDVEILKEELEKEKKKLQSERDKILKEAKEKARKIIQEAKFTAEEIIKKIREAEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TQNKDRIIQEVREELKKNLEELEEEVLKPKEAHYSRIPDNLKEGQTVYIVPLDQNGIVLS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCCEEEEEEECCCCEEEE
LPDKSGNVEVQAGILKMTVHISNLRVAEEKEEEEVKKGYSKFVHEKSQSISTSIDVRGKN
CCCCCCCEEEEECEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LDDALLEVEKYIDDAYLAGLKEVTIIHGRGTGVLRTGISQFLRSNKHVKSFRLGKYGEGG
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
DGVTIVELANK
CCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]