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The map label for this gene is hyuA [H]

Identifier: 167040590

GI number: 167040590

Start: 1972654

End: 1974204

Strand: Reverse

Name: hyuA [H]

Synonym: Teth514_1963

Alternate gene names: 167040590

Gene position: 1974204-1972654 (Counterclockwise)

Preceding gene: 167040591

Following gene: 167040589

Centisome position: 80.34

GC content: 38.75

Gene sequence:

>1551_bases
ATGGAATATCGTATTGGAATTGATGTTGGTGGGACCAATACTGACGCAGTCTTAGTAAATGAAAATATGGAACTAATAGA
GAGTGTTAAAGTACCGACTACTAAAGATGTTTCAAGCGGTATATTTGAAGCATTGAATAAGGTATTAGATAAAAGTAACA
TAGATCGCAAAAAGATAAAATATGCAATGTTAGGAACAACCCATGCTACAAATGCCATTGCTGAGCGCAAAAGGCTTTGT
AAGACTGCAATTATTCGAATTGGTAAACCCGCAACCGAAGCAATTGCTCCGCTAGTTGGTTGGCCTAAGGATTTGGTTGA
GGCGGTAGGGAATCATTATTACCTAATTGCCGGTGGAAATGAATTTGATGGCAGAGAAATAAGTCCACTAGATGAAGATG
AGCTTGGTAAAATCGCCAAGGAAATTAAAGGCAAAGTAGAAAGTGTTGCGGTAATATCTGTATTTTCTCCGGTTAGCAAT
AAACATGAATTAAGAGCAAAAGAAATATTGCAAGAAGTTCTTGGGGAAATACCAATATCTCTATCTCATGAAATTGGTTC
CCTTGGCCTACTTGAGAGGGAAAATGCTACTGTTTTAAACGCCGCTTTAGTTGAAGTTGCTCGGACAACTGCTAATAGTT
TTAAAGATGCTTTGAAACGAGAAGGTCTTACAGAGGCTACCGTATATCTTTGTCAAAACGATGGAACTTTAATGTCGATT
GATTATGCGATGCGTTATCCTATCTTAACAATTGCTTGTGGTCCTACAAACAGTATTCGTGGAGCAGCTTTTCTTAGTAA
GCTAGAAAATGCATTAGTGCTTGACGTTGGTGGAACTACAAGTGACATTGGAGTTATTTCTCAGGGATTTCCTAGAGAAT
CTTCCATTGCAGTAGAAATTGGCGGGGTGCGGACAAACTTTAGAATGCCTGACTTAATTTCACTCGCACTTGGCGGTGGT
ACAACTATTCGTGAAGAGAACGGCGAAATTAAAGTAGGTCCTGAAAGTGTAGGGTATAGAATTACCGAAGAGGCTTTGGT
ATTTGGAGGGAAAACCATAACTGCTACTGACATTGCAGTTCGTTTAGGATTGGCAGAAGTAGGTTCTAAGGAAAAAGTAA
AAGATATACCTTTAGAATTTGCTAAGCGAGCACATGCCAAAATGCAAGAAATGATTAATGAAGCCATTGACAAAATGAAA
ACCAGTAAAGAACCACAACCTCTTGTATTGGTTGGCGGAGGAAGTATTATTGTTGCCGATGAAGTACACGGTGTAAATGA
AATAGTAAGGCCGAAAAATTTTGGAGTAGCCAATGCTTTAGGTGCTGCTATAGCTCAGGTTAGTGGTGAAATAGATCGCA
TTTATTCTTTGAGTGATATGAGCAGAGAGGCAGCATTAAACGATGCAAAGCAACGGGCAATAAATGAAGCAATAAAAGCA
GGGGCTAATCCTGAATCAGTGGATGTCGTTTATGTTGAAGATATACCTTTAGCTTATCTTCCCGGAAATGCAGTTAGAAT
TAGAGTTAAAGCAGCAGGAAATTTAATTTAA

Upstream 100 bases:

>100_bases
GAAAAAGGCATTGAAACTGTTGGTCCGCGTTACTTTGGATATGATGTTGATTATATACCTTTAGAAGAACTCAATAGAGG
TTAAAAGGAGGTAGAAAAAG

Downstream 100 bases:

>100_bases
CAGACTTTAGTAATTTACTTCCATCTTCTATAAAATGGAGATGAATTAGAGTATAAATGGAAACCAAATCTGGGGAGGCA
TTTACCTTACGAGTAGTAGG

Product: hydantoinase/oxoprolinase

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MEYRIGIDVGGTNTDAVLVNENMELIESVKVPTTKDVSSGIFEALNKVLDKSNIDRKKIKYAMLGTTHATNAIAERKRLC
KTAIIRIGKPATEAIAPLVGWPKDLVEAVGNHYYLIAGGNEFDGREISPLDEDELGKIAKEIKGKVESVAVISVFSPVSN
KHELRAKEILQEVLGEIPISLSHEIGSLGLLERENATVLNAALVEVARTTANSFKDALKREGLTEATVYLCQNDGTLMSI
DYAMRYPILTIACGPTNSIRGAAFLSKLENALVLDVGGTTSDIGVISQGFPRESSIAVEIGGVRTNFRMPDLISLALGGG
TTIREENGEIKVGPESVGYRITEEALVFGGKTITATDIAVRLGLAEVGSKEKVKDIPLEFAKRAHAKMQEMINEAIDKMK
TSKEPQPLVLVGGGSIIVADEVHGVNEIVRPKNFGVANALGAAIAQVSGEIDRIYSLSDMSREAALNDAKQRAINEAIKA
GANPESVDVVYVEDIPLAYLPGNAVRIRVKAAGNLI

Sequences:

>Translated_516_residues
MEYRIGIDVGGTNTDAVLVNENMELIESVKVPTTKDVSSGIFEALNKVLDKSNIDRKKIKYAMLGTTHATNAIAERKRLC
KTAIIRIGKPATEAIAPLVGWPKDLVEAVGNHYYLIAGGNEFDGREISPLDEDELGKIAKEIKGKVESVAVISVFSPVSN
KHELRAKEILQEVLGEIPISLSHEIGSLGLLERENATVLNAALVEVARTTANSFKDALKREGLTEATVYLCQNDGTLMSI
DYAMRYPILTIACGPTNSIRGAAFLSKLENALVLDVGGTTSDIGVISQGFPRESSIAVEIGGVRTNFRMPDLISLALGGG
TTIREENGEIKVGPESVGYRITEEALVFGGKTITATDIAVRLGLAEVGSKEKVKDIPLEFAKRAHAKMQEMINEAIDKMK
TSKEPQPLVLVGGGSIIVADEVHGVNEIVRPKNFGVANALGAAIAQVSGEIDRIYSLSDMSREAALNDAKQRAINEAIKA
GANPESVDVVYVEDIPLAYLPGNAVRIRVKAAGNLI
>Mature_516_residues
MEYRIGIDVGGTNTDAVLVNENMELIESVKVPTTKDVSSGIFEALNKVLDKSNIDRKKIKYAMLGTTHATNAIAERKRLC
KTAIIRIGKPATEAIAPLVGWPKDLVEAVGNHYYLIAGGNEFDGREISPLDEDELGKIAKEIKGKVESVAVISVFSPVSN
KHELRAKEILQEVLGEIPISLSHEIGSLGLLERENATVLNAALVEVARTTANSFKDALKREGLTEATVYLCQNDGTLMSI
DYAMRYPILTIACGPTNSIRGAAFLSKLENALVLDVGGTTSDIGVISQGFPRESSIAVEIGGVRTNFRMPDLISLALGGG
TTIREENGEIKVGPESVGYRITEEALVFGGKTITATDIAVRLGLAEVGSKEKVKDIPLEFAKRAHAKMQEMINEAIDKMK
TSKEPQPLVLVGGGSIIVADEVHGVNEIVRPKNFGVANALGAAIAQVSGEIDRIYSLSDMSREAALNDAKQRAINEAIKA
GANPESVDVVYVEDIPLAYLPGNAVRIRVKAAGNLI

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Drosophila melanogaster, GI45550492, Length=509, Percent_Identity=24.950884086444, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 55265; Mature: 55265

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIGIDVGGTNTDAVLVNENMELIESVKVPTTKDVSSGIFEALNKVLDKSNIDRKKIK
CCEEEEEEECCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEE
YAMLGTTHATNAIAERKRLCKTAIIRIGKPATEAIAPLVGWPKDLVEAVGNHYYLIAGGN
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEECCC
EFDGREISPLDEDELGKIAKEIKGKVESVAVISVFSPVSNKHELRAKEILQEVLGEIPIS
CCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCE
LSHEIGSLGLLERENATVLNAALVEVARTTANSFKDALKREGLTEATVYLCQNDGTLMSI
ECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
DYAMRYPILTIACGPTNSIRGAAFLSKLENALVLDVGGTTSDIGVISQGFPRESSIAVEI
EHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCCCCCEEEEE
GGVRTNFRMPDLISLALGGGTTIREENGEIKVGPESVGYRITEEALVFGGKTITATDIAV
CCEEECCCCCCHHEEEECCCCEEEECCCCEEECHHHHCCEEECHHHEECCCEEEEEHHHH
RLGLAEVGSKEKVKDIPLEFAKRAHAKMQEMINEAIDKMKTSKEPQPLVLVGGGSIIVAD
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEE
EVHGVNEIVRPKNFGVANALGAAIAQVSGEIDRIYSLSDMSREAALNDAKQRAINEAIKA
CCCCHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHC
GANPESVDVVYVEDIPLAYLPGNAVRIRVKAAGNLI
CCCCCCEEEEEEECCCEEEECCCEEEEEEECCCCCC
>Mature Secondary Structure
MEYRIGIDVGGTNTDAVLVNENMELIESVKVPTTKDVSSGIFEALNKVLDKSNIDRKKIK
CCEEEEEEECCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEE
YAMLGTTHATNAIAERKRLCKTAIIRIGKPATEAIAPLVGWPKDLVEAVGNHYYLIAGGN
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEECCC
EFDGREISPLDEDELGKIAKEIKGKVESVAVISVFSPVSNKHELRAKEILQEVLGEIPIS
CCCCCCCCCCCHHHHHHHHHHHCCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCE
LSHEIGSLGLLERENATVLNAALVEVARTTANSFKDALKREGLTEATVYLCQNDGTLMSI
ECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
DYAMRYPILTIACGPTNSIRGAAFLSKLENALVLDVGGTTSDIGVISQGFPRESSIAVEI
EHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCCCCCEEEEE
GGVRTNFRMPDLISLALGGGTTIREENGEIKVGPESVGYRITEEALVFGGKTITATDIAV
CCEEECCCCCCHHEEEECCCCEEEECCCCEEECHHHHCCEEECHHHEECCCEEEEEHHHH
RLGLAEVGSKEKVKDIPLEFAKRAHAKMQEMINEAIDKMKTSKEPQPLVLVGGGSIIVAD
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEE
EVHGVNEIVRPKNFGVANALGAAIAQVSGEIDRIYSLSDMSREAALNDAKQRAINEAIKA
CCCCHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHC
GANPESVDVVYVEDIPLAYLPGNAVRIRVKAAGNLI
CCCCCCEEEEEEECCCEEEECCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]