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The map label for this gene is serA [H]

Identifier: 167040546

GI number: 167040546

Start: 1928756

End: 1929730

Strand: Reverse

Name: serA [H]

Synonym: Teth514_1916

Alternate gene names: 167040546

Gene position: 1929730-1928756 (Counterclockwise)

Preceding gene: 167040547

Following gene: 167040545

Centisome position: 78.53

GC content: 34.97

Gene sequence:

>975_bases
ATGAAAAAAGTATTGCTTTCAGAGGAGATACATCCAGAGGGAAGAAAGTTATTAGAGGGAAAATTTGAAATTGTTACAGC
ACCTGATACAAGTCAACAAACGCTTATATCTATGGTAAAAGATGTAGATGCTATTATTTTAAGAACTAGATCAAAGATTA
CAAGGGAAGTAATCGAGAATGCTCCACATTTAAAGATAATATCGAGGACAGGGGCAGGAGTTGATAATATAGATGTAAAT
GCAGCAACAGAAAAAGGTATATTGGTTTGTAATTTGCCAGCAGTAAATAATTTATCTGTAGCAGAACACACAATAGCAAT
GATACTAAATTTATCAAAACAGTTAAGTTTAATGGATAAAGCTGTTCGCAGTGGCAATTGGGGAGCGAGAAACTCTAATA
TTTCAGTGGAGATAGAAGGGAAAGTACTTGGAATTGTTGGAATGGGGAATATAGGAAGTTTAGTTGCAAAAAAGTGCCAT
GATGGATTGGGAATGAAAATAGTTGCTTATGATCCATATGTAAAAGAAAAGTTTAGGGGTTATGATTATAAATTTGTTGA
CACGCGTGAGGAACTATTTAAAGAATCAGATTTTGTAACGTTGCATTGTCCTGATATACCTGAGACAAGAGGAATGATAA
CGAGAGAGCTTATATATTCTATGAAGCATACAGCTTATTTAATAAATGCGGCAAGAGGAACAGTAATAGACGAACAAGCT
TTGATTGAGGCTTTAAAAGAAAAAAGGATCGCAGGAGCAGGCCTTGATGTGTTTCAGCAAGAGCCACCATCAAGCGATAA
TGAATTATTAAGACTTGAGAATGTAATACTATCTCCTCATTCAGCAGCTCTAACAAAAGAAGCGACTGTACGTATGGCAG
TAGAAGCTGTCCAAGCCGTTATTGATTATTTTGAAGGCCGTCAACCAAAATATATTTATAATTACAAAGCTTTAAAAGAG
AAGGGGTATATATAA

Upstream 100 bases:

>100_bases
TAGGTTATTATGGAATGGAGCCAAGACTACCATTATTACCGTTAAATGAAAATGAAATTGAGGAAATTAGAAGAATTTTA
CAGGAAGAAGGGCTACTTGC

Downstream 100 bases:

>100_bases
TTTGTTGATCTGAAAGTATTAAATAATATAGTAAATAAATCCTTACTTTTTATACAGATTAGTAAACGATTTTTGAAGGA
GGTGATGGAATAATTTAAGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKKVLLSEEIHPEGRKLLEGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREVIENAPHLKIISRTGAGVDNIDVN
AATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCH
DGLGMKIVAYDPYVKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQA
LIEALKEKRIAGAGLDVFQQEPPSSDNELLRLENVILSPHSAALTKEATVRMAVEAVQAVIDYFEGRQPKYIYNYKALKE
KGYI

Sequences:

>Translated_324_residues
MKKVLLSEEIHPEGRKLLEGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREVIENAPHLKIISRTGAGVDNIDVN
AATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCH
DGLGMKIVAYDPYVKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQA
LIEALKEKRIAGAGLDVFQQEPPSSDNELLRLENVILSPHSAALTKEATVRMAVEAVQAVIDYFEGRQPKYIYNYKALKE
KGYI
>Mature_324_residues
MKKVLLSEEIHPEGRKLLEGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREVIENAPHLKIISRTGAGVDNIDVN
AATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCH
DGLGMKIVAYDPYVKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQA
LIEALKEKRIAGAGLDVFQQEPPSSDNELLRLENVILSPHSAALTKEATVRMAVEAVQAVIDYFEGRQPKYIYNYKALKE
KGYI

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=37.9310344827586, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI4557497, Length=270, Percent_Identity=36.6666666666667, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI61743967, Length=270, Percent_Identity=36.6666666666667, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.9259259259259, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=35.9259259259259, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=35.9259259259259, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=28.9156626506024, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=36.2637362637363, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789279, Length=269, Percent_Identity=35.3159851301115, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787645, Length=272, Percent_Identity=30.8823529411765, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788660, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081824, Length=255, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=309, Percent_Identity=34.9514563106796, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147481, Length=293, Percent_Identity=31.3993174061433, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=318, Percent_Identity=35.8490566037736, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322116, Length=284, Percent_Identity=36.9718309859155, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324964, Length=329, Percent_Identity=27.6595744680851, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=313, Percent_Identity=29.7124600638978, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6325144, Length=179, Percent_Identity=30.7262569832402, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=163, Percent_Identity=28.8343558282209, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921140, Length=318, Percent_Identity=36.1635220125786, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=29.6529968454259, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=270, Percent_Identity=33.7037037037037, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=270, Percent_Identity=33.7037037037037, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=270, Percent_Identity=33.7037037037037, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=270, Percent_Identity=33.7037037037037, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=270, Percent_Identity=33.7037037037037, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=30.379746835443, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=30.2469135802469, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=30.2469135802469, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=30.2469135802469, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=30.2469135802469, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571528, Length=286, Percent_Identity=32.8671328671329, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=26.1324041811847, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36000; Mature: 36000

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLLSEEIHPEGRKLLEGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREVIEN
CCCCCCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMDK
CCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPYVKEKFRG
HHHCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCHHHHHHCC
YDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQA
CCEEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEECHHH
LIEALKEKRIAGAGLDVFQQEPPSSDNELLRLENVILSPHSAALTKEATVRMAVEAVQAV
HHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IDYFEGRQPKYIYNYKALKEKGYI
HHHHCCCCCCEEECHHHHHHCCCC
>Mature Secondary Structure
MKKVLLSEEIHPEGRKLLEGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREVIEN
CCCCCCCCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQLSLMDK
CCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPYVKEKFRG
HHHCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHCCCCCEEEEEECCHHHHHHCC
YDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTVIDEQA
CCEEEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEECHHH
LIEALKEKRIAGAGLDVFQQEPPSSDNELLRLENVILSPHSAALTKEATVRMAVEAVQAV
HHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IDYFEGRQPKYIYNYKALKEKGYI
HHHHCCCCCCEEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]