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The map label for this gene is mtaD

Identifier: 167040516

GI number: 167040516

Start: 1899345

End: 1900640

Strand: Reverse

Name: mtaD

Synonym: Teth514_1885

Alternate gene names: 167040516

Gene position: 1900640-1899345 (Counterclockwise)

Preceding gene: 167040517

Following gene: 167040515

Centisome position: 77.35

GC content: 35.42

Gene sequence:

>1296_bases
ATGAATCTGCTTATAAAAAATGTAGCTTTGCTATCTATGAAAGAAGAACAGCCACTTATGGAAAACACCAATATCTATAT
TGAAGGCGACACGATAACTTACATAGGAGAAATTAATCCGGATATAAAAGTTGACAGAGTCATAGATGGAACAAAAAAAA
TTGCAACGCCGGGTCTTATAAATGCTCATACTCATTTGGGAATGTCTTTACTTAGGAATTATGCAGATGATGTGCCGTTA
TTTGATTGGTTGAGTAAACATATCTGGCCTGTTGAATCTAAACTTTCAGCAGAAGACGTTTACTGGGGTTCTTTATTGAG
TATGATAGAGATGATTTATTCTGGTACTACTACTTTTTGCGATATGTATTTTTTTATGGATGAAGTAGCTAAAGCAACAG
AAGAAGTAGGGATAAGAGGAGTGTTGACAAGGGGTATTATAGAAGAAAGTGACGCTGAAATAAATAAGGAAAAGTTAAGA
GATACGCGAAAACTTTATAATACCTGGCATAATAAAGCGGATGGAAGAATCAAAGTAATGGTGGGTCCTCATGCACCTTA
TACTTGTAGCTCCTCTTATTTGAAGGAAGTAGTAGAATTGGCTAAGGAGTTAAATACAGGAATTCATATTCATGTATCAG
AAACAAAAAAAGAAGTAGAAGAAAGTTTCCAAAAGCATGGAAAATCTCCTGTGAAACATTTAAAGGACATAGGAGTATTT
GATGTTCCGACTGTAGCAGCTCATTGTGTTCATGTAAGCGATGAAGACACTGAAATATTAAAGGAAATGAAGGTATCACC
AGTTTACAATCCTACCAGTAATGCCAAGTTAGCCAGTGGTTTTGCTCCTGTGGATCAAATGCTAAAAAAAGGAATAAACG
TAGCTTTGGGAACAGATGGTCCAGCCAGTAACAATAACCTAAACATGTTTGAAGAGATTCATTTTGCTGCCACTATTAAT
AAGGCGTTAAATTACGATGCTCTTGCCGTACCGGCCTTGGAAGCTCTAAAAATGGCGACAATCAATGGCGCTAAAGCTTT
ATTGTGGGATAAAGAGATAGGTTCCATCGAAGTAGGGAAAAAAGCGGATATAGTGATTATTGATATTGACAAGCCGCATT
TTTATCCACACCACAACTTAATTTCTGCTTTAGCTTATACTGCTCAAGCATCAGATGTGGATACAGTAATAATAAATGGC
AAAATAATAATGGAAAATAGAGAAATAAAAACTGTAGATGTGGAAAAAGTAATGTATAACGTGGAGAAAAGAGCAAAAAA
TTTGATACAAAGATAA

Upstream 100 bases:

>100_bases
CAACTATTTGCGCAAGATGTGCTTCTCACATTGAGCAGCAAACACAAGTTTAAAAAGGGGATTTTTCCCCTTTTTAAACA
TTATTTTTAGGAGGGATATT

Downstream 100 bases:

>100_bases
GGTGTTCTGGATTGTAGACAAGGTCTCATTTAAGAAGTTTTTGAATTTGGCATAAAAAGTTTGTCAAAAAATTGAGGTAT
TCTGACAATAAGTCAGAATA

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNLLIKNVALLSMKEEQPLMENTNIYIEGDTITYIGEINPDIKVDRVIDGTKKIATPGLINAHTHLGMSLLRNYADDVPL
FDWLSKHIWPVESKLSAEDVYWGSLLSMIEMIYSGTTTFCDMYFFMDEVAKATEEVGIRGVLTRGIIEESDAEINKEKLR
DTRKLYNTWHNKADGRIKVMVGPHAPYTCSSSYLKEVVELAKELNTGIHIHVSETKKEVEESFQKHGKSPVKHLKDIGVF
DVPTVAAHCVHVSDEDTEILKEMKVSPVYNPTSNAKLASGFAPVDQMLKKGINVALGTDGPASNNNLNMFEEIHFAATIN
KALNYDALAVPALEALKMATINGAKALLWDKEIGSIEVGKKADIVIIDIDKPHFYPHHNLISALAYTAQASDVDTVIING
KIIMENREIKTVDVEKVMYNVEKRAKNLIQR

Sequences:

>Translated_431_residues
MNLLIKNVALLSMKEEQPLMENTNIYIEGDTITYIGEINPDIKVDRVIDGTKKIATPGLINAHTHLGMSLLRNYADDVPL
FDWLSKHIWPVESKLSAEDVYWGSLLSMIEMIYSGTTTFCDMYFFMDEVAKATEEVGIRGVLTRGIIEESDAEINKEKLR
DTRKLYNTWHNKADGRIKVMVGPHAPYTCSSSYLKEVVELAKELNTGIHIHVSETKKEVEESFQKHGKSPVKHLKDIGVF
DVPTVAAHCVHVSDEDTEILKEMKVSPVYNPTSNAKLASGFAPVDQMLKKGINVALGTDGPASNNNLNMFEEIHFAATIN
KALNYDALAVPALEALKMATINGAKALLWDKEIGSIEVGKKADIVIIDIDKPHFYPHHNLISALAYTAQASDVDTVIING
KIIMENREIKTVDVEKVMYNVEKRAKNLIQR
>Mature_431_residues
MNLLIKNVALLSMKEEQPLMENTNIYIEGDTITYIGEINPDIKVDRVIDGTKKIATPGLINAHTHLGMSLLRNYADDVPL
FDWLSKHIWPVESKLSAEDVYWGSLLSMIEMIYSGTTTFCDMYFFMDEVAKATEEVGIRGVLTRGIIEESDAEINKEKLR
DTRKLYNTWHNKADGRIKVMVGPHAPYTCSSSYLKEVVELAKELNTGIHIHVSETKKEVEESFQKHGKSPVKHLKDIGVF
DVPTVAAHCVHVSDEDTEILKEMKVSPVYNPTSNAKLASGFAPVDQMLKKGINVALGTDGPASNNNLNMFEEIHFAATIN
KALNYDALAVPALEALKMATINGAKALLWDKEIGSIEVGKKADIVIIDIDKPHFYPHHNLISALAYTAQASDVDTVIING
KIIMENREIKTVDVEKVMYNVEKRAKNLIQR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=27.1767810026385, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI87082177, Length=455, Percent_Identity=26.3736263736264, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789249, Length=370, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17540282, Length=424, Percent_Identity=25, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319963, Length=330, Percent_Identity=25.7575757575758, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24643849, Length=392, Percent_Identity=26.0204081632653, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_THEP3 (B0K8R8)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664867.1
- ProteinModelPortal:   B0K8R8
- SMR:   B0K8R8
- GeneID:   5873649
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0875
- HOGENOM:   HBG668170
- OMA:   KVIDMAT
- ProtClustDB:   CLSK901320
- BioCyc:   TPSE340099:TETH39_0875-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48135; Mature: 48135

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: BINDING 92-92 BINDING 144-144 BINDING 184-184 BINDING 214-214 BINDING 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIKNVALLSMKEEQPLMENTNIYIEGDTITYIGEINPDIKVDRVIDGTKKIATPGLI
CCCHHHHHHHEEECCCCCCHHCCEEEEECCEEEEEECCCCCCEEEHEECCCHHHCCCCCC
NAHTHLGMSLLRNYADDVPLFDWLSKHIWPVESKLSAEDVYWGSLLSMIEMIYSGTTTFC
CHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
DMYFFMDEVAKATEEVGIRGVLTRGIIEESDAEINKEKLRDTRKLYNTWHNKADGRIKVM
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
VGPHAPYTCSSSYLKEVVELAKELNTGIHIHVSETKKEVEESFQKHGKSPVKHLKDIGVF
ECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHCCCC
DVPTVAAHCVHVSDEDTEILKEMKVSPVYNPTSNAKLASGFAPVDQMLKKGINVALGTDG
CCCHHHHHEEECCCCHHHHHHHHCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEEEECCCC
PASNNNLNMFEEIHFAATINKALNYDALAVPALEALKMATINGAKALLWDKEIGSIEVGK
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCC
KADIVIIDIDKPHFYPHHNLISALAYTAQASDVDTVIINGKIIMENREIKTVDVEKVMYN
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECEEEEECCCEEEEEHHHHHHH
VEKRAKNLIQR
HHHHHHHHHCC
>Mature Secondary Structure
MNLLIKNVALLSMKEEQPLMENTNIYIEGDTITYIGEINPDIKVDRVIDGTKKIATPGLI
CCCHHHHHHHEEECCCCCCHHCCEEEEECCEEEEEECCCCCCEEEHEECCCHHHCCCCCC
NAHTHLGMSLLRNYADDVPLFDWLSKHIWPVESKLSAEDVYWGSLLSMIEMIYSGTTTFC
CHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
DMYFFMDEVAKATEEVGIRGVLTRGIIEESDAEINKEKLRDTRKLYNTWHNKADGRIKVM
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEE
VGPHAPYTCSSSYLKEVVELAKELNTGIHIHVSETKKEVEESFQKHGKSPVKHLKDIGVF
ECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHCCCC
DVPTVAAHCVHVSDEDTEILKEMKVSPVYNPTSNAKLASGFAPVDQMLKKGINVALGTDG
CCCHHHHHEEECCCCHHHHHHHHCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEEEECCCC
PASNNNLNMFEEIHFAATINKALNYDALAVPALEALKMATINGAKALLWDKEIGSIEVGK
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCC
KADIVIIDIDKPHFYPHHNLISALAYTAQASDVDTVIINGKIIMENREIKTVDVEKVMYN
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECEEEEECCCEEEEEHHHHHHH
VEKRAKNLIQR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA