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The map label for this gene is ispA [C]

Identifier: 167040176

GI number: 167040176

Start: 1560205

End: 1561089

Strand: Direct

Name: ispA [C]

Synonym: Teth514_1538

Alternate gene names: 167040176

Gene position: 1560205-1561089 (Clockwise)

Preceding gene: 167040175

Following gene: 167040177

Centisome position: 63.49

GC content: 34.58

Gene sequence:

>885_bases
ATGTTTAAAGAAAAGTTAAGAGAAAAACAACAGCTTGTTGAGAAAGAACTACACAGAATACTTGATATAGAAGAAAAACC
AGAGATAATTTATGAAGCAATGAGATATAGTGTGTTTGCGGGAGGGAAAAGGTTAAGACCAGTTTTATGTCTTTCTTCTT
GTGAGCTTTTAGGAGGAGATATAAAAAAAGCTCTTCCTGTAGCTTGTGCGATTGAACTTATTCATACTTATTCTCTGATT
CACGATGACCTTCCAGCCATGGATAATGATGATTTAAGAAGAGGAAAGCCCACGAATCACAAAGTTTATGGAGAAGCTAT
AGCAATTTTAGCTGGCGATGGTCTTTTAAATTTAGGGTATGAAGTGTTAGTAAGACATGCTTTAGAACATCCGGAAGATT
ATGAAAGAATATTGAAAGCTACCAATGAGATTGCGACAGCCTCAGGATGTAAAGGAATTATTGGTGGGCAAGTGGTAGAT
ATACTTTCACAAAACACGAAACTTACCTATGAAGAATTAAAATTCATTCATGAACACAAAACAGCGGCTTTGATAGAAGC
GTCTGTTTGTGCAGGAGCTTACATTGCTGGTGCTACAGAAGAAGATGTTCATGCCTTAAGGGAATATGCACGCTTAATAG
GTTTTGCTTTTCAAATAAAAGATGATATATTGGATGTAATAGGAGAAGAGGAAAAATTGGGTAAAAAAGTGGGCAGTGAT
AGAGAAAAAGGTAAGTTTACTTTTGTCAATATTTTTGAATTAGAAAAATCTCAGGAGATGGTTGTAGAACTTACACAAAA
TGCTGTAAAGATTTTAGATAGATTTGGGGAAAAAGCGCTCTTTCTTAAAGAATTGTCTAATTATTTAATTGAGAGAGTAA
ACTGA

Upstream 100 bases:

>100_bases
ATTTCTAAAAGATTAGAAAAAAGGTTAAGTGAGGTTGAAGGAAAGATAACCCTTCTCATCAACGAAAATGAAGAAATTGA
TTTTAAAGAGGAGGAAAAGG

Downstream 100 bases:

>100_bases
AGAATAGAGGAGTATTGACAATACTTTTCAAAAGAAATGAGTTTTTTGACATTTAAGGGATTGTAGCAACCTTCTAACGA
CTTTGTAGCGGTTTGATATT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFKEKLREKQQLVEKELHRILDIEEKPEIIYEAMRYSVFAGGKRLRPVLCLSSCELLGGDIKKALPVACAIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVYGEAIAILAGDGLLNLGYEVLVRHALEHPEDYERILKATNEIATASGCKGIIGGQVVD
ILSQNTKLTYEELKFIHEHKTAALIEASVCAGAYIAGATEEDVHALREYARLIGFAFQIKDDILDVIGEEEKLGKKVGSD
REKGKFTFVNIFELEKSQEMVVELTQNAVKILDRFGEKALFLKELSNYLIERVN

Sequences:

>Translated_294_residues
MFKEKLREKQQLVEKELHRILDIEEKPEIIYEAMRYSVFAGGKRLRPVLCLSSCELLGGDIKKALPVACAIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVYGEAIAILAGDGLLNLGYEVLVRHALEHPEDYERILKATNEIATASGCKGIIGGQVVD
ILSQNTKLTYEELKFIHEHKTAALIEASVCAGAYIAGATEEDVHALREYARLIGFAFQIKDDILDVIGEEEKLGKKVGSD
REKGKFTFVNIFELEKSQEMVVELTQNAVKILDRFGEKALFLKELSNYLIERVN
>Mature_294_residues
MFKEKLREKQQLVEKELHRILDIEEKPEIIYEAMRYSVFAGGKRLRPVLCLSSCELLGGDIKKALPVACAIELIHTYSLI
HDDLPAMDNDDLRRGKPTNHKVYGEAIAILAGDGLLNLGYEVLVRHALEHPEDYERILKATNEIATASGCKGIIGGQVVD
ILSQNTKLTYEELKFIHEHKTAALIEASVCAGAYIAGATEEDVHALREYARLIGFAFQIKDDILDVIGEEEKLGKKVGSD
REKGKFTFVNIFELEKSQEMVVELTQNAVKILDRFGEKALFLKELSNYLIERVN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=249, Percent_Identity=28.9156626506024, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=39.9328859060403, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1789578, Length=223, Percent_Identity=33.6322869955157, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=194, Percent_Identity=29.3814432989691, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508563, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651612, Length=250, Percent_Identity=29.2, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137582, Length=243, Percent_Identity=28.3950617283951, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33070; Mature: 33070

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKEKLREKQQLVEKELHRILDIEEKPEIIYEAMRYSVFAGGKRLRPVLCLSSCELLGGD
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
IKKALPVACAIELIHTYSLIHDDLPAMDNDDLRRGKPTNHKVYGEAIAILAGDGLLNLGY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCHHHHHH
EVLVRHALEHPEDYERILKATNEIATASGCKGIIGGQVVDILSQNTKLTYEELKFIHEHK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TAALIEASVCAGAYIAGATEEDVHALREYARLIGFAFQIKDDILDVIGEEEKLGKKVGSD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
REKGKFTFVNIFELEKSQEMVVELTQNAVKILDRFGEKALFLKELSNYLIERVN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKEKLREKQQLVEKELHRILDIEEKPEIIYEAMRYSVFAGGKRLRPVLCLSSCELLGGD
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCH
IKKALPVACAIELIHTYSLIHDDLPAMDNDDLRRGKPTNHKVYGEAIAILAGDGLLNLGY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEEEEECCCHHHHHH
EVLVRHALEHPEDYERILKATNEIATASGCKGIIGGQVVDILSQNTKLTYEELKFIHEHK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TAALIEASVCAGAYIAGATEEDVHALREYARLIGFAFQIKDDILDVIGEEEKLGKKVGSD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
REKGKFTFVNIFELEKSQEMVVELTQNAVKILDRFGEKALFLKELSNYLIERVN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]