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The map label for this gene is proA [H]

Identifier: 167040158

GI number: 167040158

Start: 1547962

End: 1549206

Strand: Direct

Name: proA [H]

Synonym: Teth514_1520

Alternate gene names: 167040158

Gene position: 1547962-1549206 (Clockwise)

Preceding gene: 167040157

Following gene: 167040159

Centisome position: 63.0

GC content: 36.71

Gene sequence:

>1245_bases
TTGGAAGTTGAAGTAAAGGCAAAACAGGCAAAAGCTGCGGCCAGAAGAATGGCTGTGTTAGATGAAAATACAAAGAATTT
AGCTTTGAATCACATGGCAGATGCTTTAATAAAAGATATGGGAAAAATACTTGAGGCTAATAAAAAGGATGTTGTGGAGG
CTGAAAAAAGGAATATAAAAGCTTCTCTTATTGATAGACTAAAACTTGATGAAAAAAGAGTCGAAGCTATGGCAAAAGGA
TTAAGAGAGATTTCTGCTCTTCCTGACCCTGTAGGAAGTATAGAAAAGATGTGGAAAAGACCAAATGGACTTCAAATTGG
CAAAATGAGAGTGCCAATTGGAGTAATAGGTATAATTTATGAATCTCGCCCGAATGTGACAGCTGATGCGGCAGGCCTTT
GTTTGAAATCGGGAAATGCTGTGATTTTAAGGGGAGGAAGCGATGCAATCAATTCTAATATAGCAATTTCTTCTATTCTT
GCCAAGGCTGCTTATGAGACTGGGATTCCTGAAGGTGCAATACAGCTTATAGAAAATACTGATAGAGAAGAAGTAAACCG
TATGATGAAGTTAAACGGTCTAATTGACCTCATTATTCCTCGAGGTGGAGCCAGTCTTATAAAAAATGTCATTGAAAATT
CTACAGTGCCTGTAATAGAGACAGGAGTAGGCAATTGTCATATTTTTGTTGATGAAACAGCTAAGTTTAATATAGCAAAA
GACATCATTGTGAATGCAAAAGTTCAAAGGCCAGGGGTATGTAATGCAGTAGAGACAGTTTTAGTTCACAAATCTATTGC
AAAAGAGTTTTTGCCTTTAATGGTAGAAGAATTGACTTCTTTGGGAGTAGAAATAAGAGGGTGTCAAATTACAAAAGAAA
TATGTCCTCAAGTTAAAGAGGCTACAGATAAGGATTGGGAAACGGAATATTTAGACCTTATACTGGCTGTAAAAGTTGTA
GATGGCATAGAAGAAGCCTTAGATCATATTTCAAAGTATTCCACAGGCCATTCTGAAAGCATTATTACAGAAAATTATGA
AAATGCCATGATGTTTTTAAAATCTGTAGATTCGGCTGCTGTGTATGTAAATGCTTCTACTCGCTTTACAGATGGAGGAG
AATTTGGTTTTGGGGCAGAGATAGGAATAAGTACACAAAAAATGCATGCGAGAGGGCCAATGGGACTTGAGGAGCTTACC
ACCTACAAATATGTAATTTTAGGTAGTGGACAAATAAGGAAATAA

Upstream 100 bases:

>100_bases
GGTTGTAAAACTCATGAGATAGAAAAGATATTAGGTTATAAATATTACGATGAAGTAATCCATAGGGATAATCTTGTAAT
ACTTGAAAGAGGTGAGAAGT

Downstream 100 bases:

>100_bases
GGTGTATTATAGTAAAGTGAGGTGAGATTATGAAAAGAGTTTTGATAATTCATGGCCCTAATGTAAATCTGACAGGTAAA
AGAGAAAAAGAGGTATATGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MEVEVKAKQAKAAARRMAVLDENTKNLALNHMADALIKDMGKILEANKKDVVEAEKRNIKASLIDRLKLDEKRVEAMAKG
LREISALPDPVGSIEKMWKRPNGLQIGKMRVPIGVIGIIYESRPNVTADAAGLCLKSGNAVILRGGSDAINSNIAISSIL
AKAAYETGIPEGAIQLIENTDREEVNRMMKLNGLIDLIIPRGGASLIKNVIENSTVPVIETGVGNCHIFVDETAKFNIAK
DIIVNAKVQRPGVCNAVETVLVHKSIAKEFLPLMVEELTSLGVEIRGCQITKEICPQVKEATDKDWETEYLDLILAVKVV
DGIEEALDHISKYSTGHSESIITENYENAMMFLKSVDSAAVYVNASTRFTDGGEFGFGAEIGISTQKMHARGPMGLEELT
TYKYVILGSGQIRK

Sequences:

>Translated_414_residues
MEVEVKAKQAKAAARRMAVLDENTKNLALNHMADALIKDMGKILEANKKDVVEAEKRNIKASLIDRLKLDEKRVEAMAKG
LREISALPDPVGSIEKMWKRPNGLQIGKMRVPIGVIGIIYESRPNVTADAAGLCLKSGNAVILRGGSDAINSNIAISSIL
AKAAYETGIPEGAIQLIENTDREEVNRMMKLNGLIDLIIPRGGASLIKNVIENSTVPVIETGVGNCHIFVDETAKFNIAK
DIIVNAKVQRPGVCNAVETVLVHKSIAKEFLPLMVEELTSLGVEIRGCQITKEICPQVKEATDKDWETEYLDLILAVKVV
DGIEEALDHISKYSTGHSESIITENYENAMMFLKSVDSAAVYVNASTRFTDGGEFGFGAEIGISTQKMHARGPMGLEELT
TYKYVILGSGQIRK
>Mature_414_residues
MEVEVKAKQAKAAARRMAVLDENTKNLALNHMADALIKDMGKILEANKKDVVEAEKRNIKASLIDRLKLDEKRVEAMAKG
LREISALPDPVGSIEKMWKRPNGLQIGKMRVPIGVIGIIYESRPNVTADAAGLCLKSGNAVILRGGSDAINSNIAISSIL
AKAAYETGIPEGAIQLIENTDREEVNRMMKLNGLIDLIIPRGGASLIKNVIENSTVPVIETGVGNCHIFVDETAKFNIAK
DIIVNAKVQRPGVCNAVETVLVHKSIAKEFLPLMVEELTSLGVEIRGCQITKEICPQVKEATDKDWETEYLDLILAVKVV
DGIEEALDHISKYSTGHSESIITENYENAMMFLKSVDSAAVYVNASTRFTDGGEFGFGAEIGISTQKMHARGPMGLEELT
TYKYVILGSGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=38.2775119617225, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=38.2775119617225, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=45.5882352941176, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=36.4508393285372, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=36.4508393285372, Blast_Score=261, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=37.8504672897196, Blast_Score=285, Evalue=8e-78,
Organism=Drosophila melanogaster, GI21357643, Length=410, Percent_Identity=36.0975609756098, Blast_Score=257, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45115; Mature: 45115

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVEVKAKQAKAAARRMAVLDENTKNLALNHMADALIKDMGKILEANKKDVVEAEKRNIK
CCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
ASLIDRLKLDEKRVEAMAKGLREISALPDPVGSIEKMWKRPNGLQIGKMRVPIGVIGIIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEEEE
ESRPNVTADAAGLCLKSGNAVILRGGSDAINSNIAISSILAKAAYETGIPEGAIQLIENT
ECCCCCCHHHHHHEEECCCEEEEECCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCC
DREEVNRMMKLNGLIDLIIPRGGASLIKNVIENSTVPVIETGVGNCHIFVDETAKFNIAK
CHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCCCCCHH
DIIVNAKVQRPGVCNAVETVLVHKSIAKEFLPLMVEELTSLGVEIRGCQITKEICPQVKE
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECEEECHHHCHHHHH
ATDKDWETEYLDLILAVKVVDGIEEALDHISKYSTGHSESIITENYENAMMFLKSVDSAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCEE
VYVNASTRFTDGGEFGFGAEIGISTQKMHARGPMGLEELTTYKYVILGSGQIRK
EEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MEVEVKAKQAKAAARRMAVLDENTKNLALNHMADALIKDMGKILEANKKDVVEAEKRNIK
CCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
ASLIDRLKLDEKRVEAMAKGLREISALPDPVGSIEKMWKRPNGLQIGKMRVPIGVIGIIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEEEE
ESRPNVTADAAGLCLKSGNAVILRGGSDAINSNIAISSILAKAAYETGIPEGAIQLIENT
ECCCCCCHHHHHHEEECCCEEEEECCCCHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCC
DREEVNRMMKLNGLIDLIIPRGGASLIKNVIENSTVPVIETGVGNCHIFVDETAKFNIAK
CHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCEEEECCCEEEEEEECCCCCCCHH
DIIVNAKVQRPGVCNAVETVLVHKSIAKEFLPLMVEELTSLGVEIRGCQITKEICPQVKE
HHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECEEECHHHCHHHHH
ATDKDWETEYLDLILAVKVVDGIEEALDHISKYSTGHSESIITENYENAMMFLKSVDSAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCEE
VYVNASTRFTDGGEFGFGAEIGISTQKMHARGPMGLEELTTYKYVILGSGQIRK
EEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA