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The map label for this gene is trxA [H]

Identifier: 167040076

GI number: 167040076

Start: 1469749

End: 1470072

Strand: Direct

Name: trxA [H]

Synonym: Teth514_1436

Alternate gene names: 167040076

Gene position: 1469749-1470072 (Clockwise)

Preceding gene: 167040075

Following gene: 167040078

Centisome position: 59.81

GC content: 34.26

Gene sequence:

>324_bases
ATGAAACCAGTAAATGTCACAGATGAGACTTTTGCAGAGGAAGTATACAATTCTAATAAACCTGTTTTAGTAGATTTTTG
GGCTAAATGGTGTAGACCCTGTTTAATGATGGCTCCAGTGTTAGAGGAGTTTGCGGAAGAATACGCAGATAAGATGAAAG
TGGCAAAACTGGATGTAGATGAAAATCCAGTAATCGCTTCTAAATATAGAATTATGAGCATACCTACGATGGGAGTTTTT
GTAAATGGAAAAATGGTAGACAAAGTTATAGGTTTTATGCCTAAAGAGCATTTAGTTGAAAAGCTGTCAAAATATTTAAA
ATAG

Upstream 100 bases:

>100_bases
GCAATGGGGCTATGACATATGACGAAATTGAAGAGTATTATAAATCAATTTCTCGATAAATGAAAATGTACAAAAGCAAG
TAGAAGGAGTGTATACACAA

Downstream 100 bases:

>100_bases
CTACTAAAAAAGGAGTATCTTTTTGTGAAAGATACTCCTTTTTTAGTAAAACATTATGCTATCACGTTTAAAACTTGCCG
GTCATTTACTACTTTTATAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MKPVNVTDETFAEEVYNSNKPVLVDFWAKWCRPCLMMAPVLEEFAEEYADKMKVAKLDVDENPVIASKYRIMSIPTMGVF
VNGKMVDKVIGFMPKEHLVEKLSKYLK

Sequences:

>Translated_107_residues
MKPVNVTDETFAEEVYNSNKPVLVDFWAKWCRPCLMMAPVLEEFAEEYADKMKVAKLDVDENPVIASKYRIMSIPTMGVF
VNGKMVDKVIGFMPKEHLVEKLSKYLK
>Mature_107_residues
MKPVNVTDETFAEEVYNSNKPVLVDFWAKWCRPCLMMAPVLEEFAEEYADKMKVAKLDVDENPVIASKYRIMSIPTMGVF
VNGKMVDKVIGFMPKEHLVEKLSKYLK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=36.4583333333333, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=44.7619047619048, Blast_Score=105, Evalue=6e-25,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=35.9223300970874, Blast_Score=80, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=34.6153846153846, Blast_Score=71, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=90, Percent_Identity=37.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=46.1538461538462, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=46.7532467532467, Blast_Score=73, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=34.8314606741573, Blast_Score=67, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=38.7755102040816, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=37.7777777777778, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=40.4761904761905, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=42.6666666666667, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=44.5945945945946, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=44.5945945945946, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=83, Percent_Identity=34.9397590361446, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12336; Mature: 12336

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
7.5 %Met     (Translated Protein)
9.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
7.5 %Met     (Mature Protein)
9.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVNVTDETFAEEVYNSNKPVLVDFWAKWCRPCLMMAPVLEEFAEEYADKMKVAKLDVD
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENPVIASKYRIMSIPTMGVFVNGKMVDKVIGFMPKEHLVEKLSKYLK
CCCEECCCEEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKPVNVTDETFAEEVYNSNKPVLVDFWAKWCRPCLMMAPVLEEFAEEYADKMKVAKLDVD
CCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENPVIASKYRIMSIPTMGVFVNGKMVDKVIGFMPKEHLVEKLSKYLK
CCCEECCCEEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]