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The map label for this gene is leuS [H]

Identifier: 167038923

GI number: 167038923

Start: 269275

End: 271725

Strand: Direct

Name: leuS [H]

Synonym: Teth514_0255

Alternate gene names: 167038923

Gene position: 269275-271725 (Clockwise)

Preceding gene: 167038922

Following gene: 167038924

Centisome position: 10.96

GC content: 37.82

Gene sequence:

>2451_bases
ATGGCTTACTCAGTGGATGTTGATAGAAAATGGCAAAAAAAATGGGAGGAGACAAAACTTTATAAGTTTAATCCTAAAAA
TGTAGATAAAAAGCTTTATTGCCTTGAGATGTTTTCTTATCCTTCAGGTGCCAAGCTTCACGTAGGGCATTGGTACAATT
ATGGACCTACTGATTCTTGGGCGCGTATGAAAAGAATGCAGGGATATGAAGTTTTTCATCCGATGGGATTTGACGCTTTT
GGACTTCCTGCAGAAAACTATGCTATAAAGACGGGAATACATCCTTATGATTCTACTATGGAAAATATAAGGACGATGGA
AAAGCAGCTTAAAGAAATGGGGGCGACTTTTGATTGGGACTATGAAGTAATAACTTGCTTACCGGAATACTACAAATGGA
CGCAGTGGATTTTCCTTAAACTTTTTGAGGCAGGCCTTGCCTATAGAAAAAAAGCTCCAGTAAATTGGTGTCCCAGTTGT
CAAACTGTTCTTGCAAACGAACAAGTTATAGATGGGAAATGTGAAAGGTGCGGCACTGAAGTTACAAAGAAAGATTTGAC
TCAGTGGTTTTTTAAGATAACTGCTTATGCAGAAGAACTCCTTGAAAAACTGGATGAACTTGATTGGCCTGAGAAGACAA
AAATAATGCAGAGAAATTGGATTGGAAAGTCGGATGGAGCAGAGATAGAATTTAAAGTAGCCGGAAAAGACCTGACATTT
AAGGTATTTACTACAAGAGCTGACACGCTATACGGAGCGACGTATGTAGTTATTGCGCCAGAACACGAAATTGTAGATTT
AATTACTACAGAAGAATATAAACAAGCTGTTGAAGAGTATAAAGAATACGCGAGAAAACAGAGTGAGATTGAAAGGTTGT
CTACTGAAAAAGAAAAGACAGGGGTATTTACAGGAGCATACGCAATTCATCCTCTGACGGGAGAGAAACTCCCTATTTGG
ATAGCAGACTATGTCCTTGCAACATATGGAACAGGATGTGTCATGGCTGTTCCTGCCCATGATGAAAGAGATTATGAGTT
TGCAACAAAATACAACCTTCCTATAAAAAGAGTGATAAAAGGAATAGGAGATATAGACGATAGTTTGCCTTTTGTCGAAT
ATGGAGAGCTTGTAGACAGTGGAGAATTTACAGGTTTGAAATCAGAAGAAGCGAGGATAAAAATTGTAGAAAAATTAAAG
CAAGAAGGTAGAGCAGAGTTTAAAGTAAATTACAGATTGAGGGATTGGCTTGTTTCAAGGCAGAGATACTGGGGTGCTCC
AATACCTGTCATTCACTGTGAACGGTGTGGCATAGTCCCTGTCCCAGAAGAAGATTTGCCAGTATTACTTCCTTATGATG
TGGAATTTGCTCCAACAGGTGAGTCTCCACTTAAAAAGCATGAGGGCTTTATGAATGTAACTTGTCCTAAATGTGGAGGT
AAAGCGTTAAGAGACCCCGATACTCTTGACACTTTTGTAGATTCTTCTTGGTACTTTTTAAGATATCCCGATAACAAAAA
CGACAAAGAGCCTTTCAATAAAGAATGGATAAATAAAATGTTGCCTGTTGACAAGTACGTAGGTGGAGCAGAGCATGCGA
CAATGCATCTTTTGTACGCAAGGTTTGTTACAAAGGCTTTGAGAGACTTAGGATATCTTGACTTTGATGAGCCGTTTAAA
TCATTAGTGCATCAAGGTACAATATTGGGCCCTGATGGAAGCAGAATGAGTAAATCTAAAGGAAATGTCATTTCGCCTGA
CGAATACATTAAAGAATACGGTTCTGATGTATTCAGACTCTATCTGATGTTTGGATTTGCTTATTCTGAAGGTGGGCCAT
GGAATGATGATGGTATTAAGGCAATTTCCAGATTTGTCAATAGAGTGGAGAGATTTATAGATAAATTCATAGAGACAAAA
AACAATCCTGGCAAGACTAAAGACGAAATGGGAAAAGATGAAAATGAATTAAACTATGTGAGACATTATGCTATAAAAAG
TGTGACAGAAGATGCAGAGAGATTTCAGTTTAATACTGCAATAGCGAGGATAATGGAACTGGTAAACGCTCTTTATAAAT
ACGACACAGATGTGGAAGTTAAAAATATCGAATTTTATGAAGATGTGGTGGCAGATTTAATAAGGCTTTTGGCGCCATTT
GCTCCTCACTTTTCCGAAGAAATGTGGGAAAAACTTGGATATGAATATTCTGTTTTCAATCAAAAATGGCCAAAGTGGGA
TGAAAAAGCTCTACAAAGAGATGTTGTAGAAATAGCTGTGCAGGTAAACGGCAAGGTAAGAGGAAGACTTGAAGTTCCTT
CAAATGCTCCTGACGAAGAAGTACAGAGGATTGCACTTTCAGATGATAAAATAAAATCCTACCTTGATGGAAAAGAAATA
AAGAAGGTCATAGTTGTTAAAGGCAGGCTTGTAAATATTGTTGTGAAATAA

Upstream 100 bases:

>100_bases
GTGGTACCACGGAAGTGCAAGTCTTTCGTCTCTTAAAGATGAAAGACTTTTTTTAATAAAATCGAGTTTGCTAAAAAATC
ATAGATAGGAGTGGAGGTTT

Downstream 100 bases:

>100_bases
TTAAAGGCAGGAGGCTCACTCCTGCTTTTAAAAAATAAATATTTTTTAGTGATGGTGAGGTAATTGTGATAGTAGATAGT
GATGTTAAAAAGAGTATAAA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MAYSVDVDRKWQKKWEETKLYKFNPKNVDKKLYCLEMFSYPSGAKLHVGHWYNYGPTDSWARMKRMQGYEVFHPMGFDAF
GLPAENYAIKTGIHPYDSTMENIRTMEKQLKEMGATFDWDYEVITCLPEYYKWTQWIFLKLFEAGLAYRKKAPVNWCPSC
QTVLANEQVIDGKCERCGTEVTKKDLTQWFFKITAYAEELLEKLDELDWPEKTKIMQRNWIGKSDGAEIEFKVAGKDLTF
KVFTTRADTLYGATYVVIAPEHEIVDLITTEEYKQAVEEYKEYARKQSEIERLSTEKEKTGVFTGAYAIHPLTGEKLPIW
IADYVLATYGTGCVMAVPAHDERDYEFATKYNLPIKRVIKGIGDIDDSLPFVEYGELVDSGEFTGLKSEEARIKIVEKLK
QEGRAEFKVNYRLRDWLVSRQRYWGAPIPVIHCERCGIVPVPEEDLPVLLPYDVEFAPTGESPLKKHEGFMNVTCPKCGG
KALRDPDTLDTFVDSSWYFLRYPDNKNDKEPFNKEWINKMLPVDKYVGGAEHATMHLLYARFVTKALRDLGYLDFDEPFK
SLVHQGTILGPDGSRMSKSKGNVISPDEYIKEYGSDVFRLYLMFGFAYSEGGPWNDDGIKAISRFVNRVERFIDKFIETK
NNPGKTKDEMGKDENELNYVRHYAIKSVTEDAERFQFNTAIARIMELVNALYKYDTDVEVKNIEFYEDVVADLIRLLAPF
APHFSEEMWEKLGYEYSVFNQKWPKWDEKALQRDVVEIAVQVNGKVRGRLEVPSNAPDEEVQRIALSDDKIKSYLDGKEI
KKVIVVKGRLVNIVVK

Sequences:

>Translated_816_residues
MAYSVDVDRKWQKKWEETKLYKFNPKNVDKKLYCLEMFSYPSGAKLHVGHWYNYGPTDSWARMKRMQGYEVFHPMGFDAF
GLPAENYAIKTGIHPYDSTMENIRTMEKQLKEMGATFDWDYEVITCLPEYYKWTQWIFLKLFEAGLAYRKKAPVNWCPSC
QTVLANEQVIDGKCERCGTEVTKKDLTQWFFKITAYAEELLEKLDELDWPEKTKIMQRNWIGKSDGAEIEFKVAGKDLTF
KVFTTRADTLYGATYVVIAPEHEIVDLITTEEYKQAVEEYKEYARKQSEIERLSTEKEKTGVFTGAYAIHPLTGEKLPIW
IADYVLATYGTGCVMAVPAHDERDYEFATKYNLPIKRVIKGIGDIDDSLPFVEYGELVDSGEFTGLKSEEARIKIVEKLK
QEGRAEFKVNYRLRDWLVSRQRYWGAPIPVIHCERCGIVPVPEEDLPVLLPYDVEFAPTGESPLKKHEGFMNVTCPKCGG
KALRDPDTLDTFVDSSWYFLRYPDNKNDKEPFNKEWINKMLPVDKYVGGAEHATMHLLYARFVTKALRDLGYLDFDEPFK
SLVHQGTILGPDGSRMSKSKGNVISPDEYIKEYGSDVFRLYLMFGFAYSEGGPWNDDGIKAISRFVNRVERFIDKFIETK
NNPGKTKDEMGKDENELNYVRHYAIKSVTEDAERFQFNTAIARIMELVNALYKYDTDVEVKNIEFYEDVVADLIRLLAPF
APHFSEEMWEKLGYEYSVFNQKWPKWDEKALQRDVVEIAVQVNGKVRGRLEVPSNAPDEEVQRIALSDDKIKSYLDGKEI
KKVIVVKGRLVNIVVK
>Mature_815_residues
AYSVDVDRKWQKKWEETKLYKFNPKNVDKKLYCLEMFSYPSGAKLHVGHWYNYGPTDSWARMKRMQGYEVFHPMGFDAFG
LPAENYAIKTGIHPYDSTMENIRTMEKQLKEMGATFDWDYEVITCLPEYYKWTQWIFLKLFEAGLAYRKKAPVNWCPSCQ
TVLANEQVIDGKCERCGTEVTKKDLTQWFFKITAYAEELLEKLDELDWPEKTKIMQRNWIGKSDGAEIEFKVAGKDLTFK
VFTTRADTLYGATYVVIAPEHEIVDLITTEEYKQAVEEYKEYARKQSEIERLSTEKEKTGVFTGAYAIHPLTGEKLPIWI
ADYVLATYGTGCVMAVPAHDERDYEFATKYNLPIKRVIKGIGDIDDSLPFVEYGELVDSGEFTGLKSEEARIKIVEKLKQ
EGRAEFKVNYRLRDWLVSRQRYWGAPIPVIHCERCGIVPVPEEDLPVLLPYDVEFAPTGESPLKKHEGFMNVTCPKCGGK
ALRDPDTLDTFVDSSWYFLRYPDNKNDKEPFNKEWINKMLPVDKYVGGAEHATMHLLYARFVTKALRDLGYLDFDEPFKS
LVHQGTILGPDGSRMSKSKGNVISPDEYIKEYGSDVFRLYLMFGFAYSEGGPWNDDGIKAISRFVNRVERFIDKFIETKN
NPGKTKDEMGKDENELNYVRHYAIKSVTEDAERFQFNTAIARIMELVNALYKYDTDVEVKNIEFYEDVVADLIRLLAPFA
PHFSEEMWEKLGYEYSVFNQKWPKWDEKALQRDVVEIAVQVNGKVRGRLEVPSNAPDEEVQRIALSDDKIKSYLDGKEIK
KVIVVKGRLVNIVVK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=872, Percent_Identity=35.2064220183486, Blast_Score=510, Evalue=1e-144,
Organism=Escherichia coli, GI1786861, Length=858, Percent_Identity=43.1235431235431, Blast_Score=667, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997517, Length=809, Percent_Identity=30.5315203955501, Blast_Score=341, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI71997510, Length=809, Percent_Identity=30.5315203955501, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI212645227, Length=332, Percent_Identity=31.0240963855422, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17510661, Length=682, Percent_Identity=23.3137829912023, Blast_Score=115, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323414, Length=875, Percent_Identity=38.0571428571429, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6321531, Length=426, Percent_Identity=24.6478873239437, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355409, Length=871, Percent_Identity=32.6061997703789, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17864482, Length=377, Percent_Identity=24.9336870026525, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653289, Length=377, Percent_Identity=24.9336870026525, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 94554; Mature: 94422

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSVDVDRKWQKKWEETKLYKFNPKNVDKKLYCLEMFSYPSGAKLHVGHWYNYGPTDSW
CCEECCCCHHHHHHHHHCCEEEECCCCCCHHEEEHHHHCCCCCCEEEECCCCCCCCCHHH
ARMKRMQGYEVFHPMGFDAFGLPAENYAIKTGIHPYDSTMENIRTMEKQLKEMGATFDWD
HHHHHHCCCCEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
YEVITCLPEYYKWTQWIFLKLFEAGLAYRKKAPVNWCPSCQTVLANEQVIDGKCERCGTE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHCHH
VTKKDLTQWFFKITAYAEELLEKLDELDWPEKTKIMQRNWIGKSDGAEIEFKVAGKDLTF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
KVFTTRADTLYGATYVVIAPEHEIVDLITTEEYKQAVEEYKEYARKQSEIERLSTEKEKT
EEEECCCCCEECCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVFTGAYAIHPLTGEKLPIWIADYVLATYGTGCVMAVPAHDERDYEFATKYNLPIKRVIK
CEEECCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCHHHHHH
GIGDIDDSLPFVEYGELVDSGEFTGLKSEEARIKIVEKLKQEGRAEFKVNYRLRDWLVSR
HHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHH
QRYWGAPIPVIHCERCGIVPVPEEDLPVLLPYDVEFAPTGESPLKKHEGFMNVTCPKCGG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEECCCCEECCCCCCHHHHCCCCEEEECCCCCC
KALRDPDTLDTFVDSSWYFLRYPDNKNDKEPFNKEWINKMLPVDKYVGGAEHATMHLLYA
CCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHHH
RFVTKALRDLGYLDFDEPFKSLVHQGTILGPDGSRMSKSKGNVISPDEYIKEYGSDVFRL
HHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
YLMFGFAYSEGGPWNDDGIKAISRFVNRVERFIDKFIETKNNPGKTKDEMGKDENELNYV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHH
RHYAIKSVTEDAERFQFNTAIARIMELVNALYKYDTDVEVKNIEFYEDVVADLIRLLAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCC
APHFSEEMWEKLGYEYSVFNQKWPKWDEKALQRDVVEIAVQVNGKVRGRLEVPSNAPDEE
CCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHEEECCEEEEEEECCCCCCHHH
VQRIALSDDKIKSYLDGKEIKKVIVVKGRLVNIVVK
HHHHHCCHHHHHHHHCHHHHHHHEEECCEEEEEEEC
>Mature Secondary Structure 
AYSVDVDRKWQKKWEETKLYKFNPKNVDKKLYCLEMFSYPSGAKLHVGHWYNYGPTDSW
CEECCCCHHHHHHHHHCCEEEECCCCCCHHEEEHHHHCCCCCCEEEECCCCCCCCCHHH
ARMKRMQGYEVFHPMGFDAFGLPAENYAIKTGIHPYDSTMENIRTMEKQLKEMGATFDWD
HHHHHHCCCCEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
YEVITCLPEYYKWTQWIFLKLFEAGLAYRKKAPVNWCPSCQTVLANEQVIDGKCERCGTE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHCHH
VTKKDLTQWFFKITAYAEELLEKLDELDWPEKTKIMQRNWIGKSDGAEIEFKVAGKDLTF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCEEE
KVFTTRADTLYGATYVVIAPEHEIVDLITTEEYKQAVEEYKEYARKQSEIERLSTEKEKT
EEEECCCCCEECCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVFTGAYAIHPLTGEKLPIWIADYVLATYGTGCVMAVPAHDERDYEFATKYNLPIKRVIK
CEEECCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCHHHHHH
GIGDIDDSLPFVEYGELVDSGEFTGLKSEEARIKIVEKLKQEGRAEFKVNYRLRDWLVSR
HHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHH
QRYWGAPIPVIHCERCGIVPVPEEDLPVLLPYDVEFAPTGESPLKKHEGFMNVTCPKCGG
HHHCCCCCCEEEECCCCCCCCCCCCCCEEECCCCEECCCCCCHHHHCCCCEEEECCCCCC
KALRDPDTLDTFVDSSWYFLRYPDNKNDKEPFNKEWINKMLPVDKYVGGAEHATMHLLYA
CCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHHH
RFVTKALRDLGYLDFDEPFKSLVHQGTILGPDGSRMSKSKGNVISPDEYIKEYGSDVFRL
HHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
YLMFGFAYSEGGPWNDDGIKAISRFVNRVERFIDKFIETKNNPGKTKDEMGKDENELNYV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHH
RHYAIKSVTEDAERFQFNTAIARIMELVNALYKYDTDVEVKNIEFYEDVVADLIRLLAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHCCC
APHFSEEMWEKLGYEYSVFNQKWPKWDEKALQRDVVEIAVQVNGKVRGRLEVPSNAPDEE
CCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHEEECCEEEEEEECCCCCCHHH
VQRIALSDDKIKSYLDGKEIKKVIVVKGRLVNIVVK
HHHHHCCHHHHHHHHCHHHHHHHEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]