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The map label for this gene is mtlR [H]

Identifier: 167038906

GI number: 167038906

Start: 249633

End: 251750

Strand: Direct

Name: mtlR [H]

Synonym: Teth514_0237

Alternate gene names: 167038906

Gene position: 249633-251750 (Clockwise)

Preceding gene: 167038905

Following gene: 167038907

Centisome position: 10.16

GC content: 33.14

Gene sequence:

>2118_bases
ATGAAAGAGGTGATAATTATCACACTCAATGAAAGATGTACTCAAATCCTTATCAGACTTATTAATTCTAATGCGCCTAT
TAAAATTTCTGACCTTGCAAAAATATTCAATGTAAGCAGTAGAACTATAAGATACGACCTTGATACAATCGATGAGTTTT
TAAAGTACAACAATTTGCCACAATTGATACGCAAACCGAATGTGGGTGTGAAATTTTCTGAACTATTGGAATACAGAAAT
AAAGTTTTATCTCTTCTTGATAATCTCAATATTTATTATTACAACTTATCTCAAAAAGAAAGAGTAAATATCATATTAAG
TGAACTTATACAGCAAAAAGACTACATCACTATCAATAGCATTGCAGATAAATTGATGGTGTCAAGAAGTACCATTATAA
AAGATTTAAAAGATGTAAGAGAGTGGCTTACACGTCATGGACTTCAGTTAAAGTCTGCACCGAAATATGGAATCAAAGTT
GTGGGGGATGAAAAACGATTACGAAGAGCTGCTATAGAACTTCTAACAGAGGCAATTGACGTTGATAAGGCGCTGGATAT
TGTAAAATCTCCGATTTATACTCGTTCTAGTGTAGGAATTGATAAACAAATTACCAAGCTATTTGAAGATATAGACATAC
CTTATATCGAAGAATGCATACAAATAGCAGAAAGAGAACTGGAAACTGTTTTTTCGGATGCGGCATTTTCTGGCCTTGTA
ATACACATAGCAATAGCGATTAAAAGGATTCAACTAGGGAAAGACATAATTATGCCAAAAGAAGAATTAAAAGCTTTGGA
AATTACAAAGGAATTTGCTGTTGCATCAAATATTGCAAAAATGTTGGAGGACCATTTTAAAGTTTCTATTCCTCTTGATG
AAATCGGATATATTACTGTTCATCTTCTTGGAAGTAATGTCTCAAAAACACGTCCTTATCCTAATGAAAACTGGGTTGAA
TACCAGTTATTGACGGAAAAAATTATTACAAATGTCACCAACAAAATACACCAAGATTTATCAGGAGATAGACAGCTTTT
TGAAGGGCTTTTAGACCATTTAAGGCCTACAGTATACCGGTTAAAACACGGACTTAAATTAAAAAATCCCATTTTAGATG
AGATTAAAGCAAATTATAAAGAATTGTTTGAAATAGTCAAAGAAAGTTTAAAACCTTTAGAAGATTATACAGGCAAAGCA
TTAAACGACGAAGAAATAGGTTATTTTACAATACATTTTGGTGCTGCAATTGAAAGATTAAAAGTTACTAAAGCACCTAA
GCCTAATATCCTCGTTGTATGTGGTACAGGAATAGGTACGGCGAAACTTCTTTCTTCGAGATTACAATCAGTTTTTGATG
TGAATATAGTAGATGCTGTCGCATACCATCAGGTAAAAGAAAGATTGAAAGAAAAAGATATAGATCTAATAGTATCTACT
GTTCCAATTCCTTATGAAGGTATTAAAACCATTGAAGTAAATCCGCTTCTTACAGAGAAAGACATAGAATTATTAAAAGA
CCTTGTTATTAAACCTAAGCTGCAAGGGACAGTTATTAATGATTTAATAAAAATAATAGAAAAGCATTGTGTGATAGGCA
ATCGTGAAAAGTTAATAGAAGATTTATCAAAATTTTTAAATGTAGCATCATATGAAAATACGAGAGGAGTTGTACAACCA
GTGTTAAAAGACCTTTTGACTAAGGATACTATAAAACTAAATGTTGAGGCAAAAGATTGGGAGGAAGCAGTGAGGATAGG
AGGTGAGTTATTAGAGAAAAGCGGGGCAATTGAACCGAGGTATATTGATGCAATGATAAACACTGTAAAAGAGATAGGCC
CTTACATTGTTATTGCGCCAGGAATAGCGATGCCCCACGCAAGGCCAGAAGCAGGTGCTAAAAAAATAGGCATGAGCTTA
ATTACACTAAAAAATCCTGTCAACTTTGGCAATAAAGAAAACGATCCAGTAAAAATTGTAGTTTCCCTTTGTGCAATCGA
CCATTCTTCACATCTTAAAGCATTGTCTGAACTGGTAGAACTTTTGGGAGATGAAAATACGGTAAAAACAATATGTGAGG
CAAATGACGTTGAAGAAGTGGTAAATTTGATTAAGTAG

Upstream 100 bases:

>100_bases
CCGCAGTTTATTTTATGCCATTTATTTAGTTTATTTTTGCCACATTTATATTGCAAAATGTTAAGCTTTTCATAATAATA
TAAATAGAATATAATTTAAA

Downstream 100 bases:

>100_bases
ATATTTTGTCAAATGGAGTTTGTGTGTTTGATAATGGTATTTACTATGTGAAAACAAATAAAAGATAGTTTATTTTTAGA
GGAGGGAATTTGATGGCATT

Product: transcriptional antiterminator BglG

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MKEVIIITLNERCTQILIRLINSNAPIKISDLAKIFNVSSRTIRYDLDTIDEFLKYNNLPQLIRKPNVGVKFSELLEYRN
KVLSLLDNLNIYYYNLSQKERVNIILSELIQQKDYITINSIADKLMVSRSTIIKDLKDVREWLTRHGLQLKSAPKYGIKV
VGDEKRLRRAAIELLTEAIDVDKALDIVKSPIYTRSSVGIDKQITKLFEDIDIPYIEECIQIAERELETVFSDAAFSGLV
IHIAIAIKRIQLGKDIIMPKEELKALEITKEFAVASNIAKMLEDHFKVSIPLDEIGYITVHLLGSNVSKTRPYPNENWVE
YQLLTEKIITNVTNKIHQDLSGDRQLFEGLLDHLRPTVYRLKHGLKLKNPILDEIKANYKELFEIVKESLKPLEDYTGKA
LNDEEIGYFTIHFGAAIERLKVTKAPKPNILVVCGTGIGTAKLLSSRLQSVFDVNIVDAVAYHQVKERLKEKDIDLIVST
VPIPYEGIKTIEVNPLLTEKDIELLKDLVIKPKLQGTVINDLIKIIEKHCVIGNREKLIEDLSKFLNVASYENTRGVVQP
VLKDLLTKDTIKLNVEAKDWEEAVRIGGELLEKSGAIEPRYIDAMINTVKEIGPYIVIAPGIAMPHARPEAGAKKIGMSL
ITLKNPVNFGNKENDPVKIVVSLCAIDHSSHLKALSELVELLGDENTVKTICEANDVEEVVNLIK

Sequences:

>Translated_705_residues
MKEVIIITLNERCTQILIRLINSNAPIKISDLAKIFNVSSRTIRYDLDTIDEFLKYNNLPQLIRKPNVGVKFSELLEYRN
KVLSLLDNLNIYYYNLSQKERVNIILSELIQQKDYITINSIADKLMVSRSTIIKDLKDVREWLTRHGLQLKSAPKYGIKV
VGDEKRLRRAAIELLTEAIDVDKALDIVKSPIYTRSSVGIDKQITKLFEDIDIPYIEECIQIAERELETVFSDAAFSGLV
IHIAIAIKRIQLGKDIIMPKEELKALEITKEFAVASNIAKMLEDHFKVSIPLDEIGYITVHLLGSNVSKTRPYPNENWVE
YQLLTEKIITNVTNKIHQDLSGDRQLFEGLLDHLRPTVYRLKHGLKLKNPILDEIKANYKELFEIVKESLKPLEDYTGKA
LNDEEIGYFTIHFGAAIERLKVTKAPKPNILVVCGTGIGTAKLLSSRLQSVFDVNIVDAVAYHQVKERLKEKDIDLIVST
VPIPYEGIKTIEVNPLLTEKDIELLKDLVIKPKLQGTVINDLIKIIEKHCVIGNREKLIEDLSKFLNVASYENTRGVVQP
VLKDLLTKDTIKLNVEAKDWEEAVRIGGELLEKSGAIEPRYIDAMINTVKEIGPYIVIAPGIAMPHARPEAGAKKIGMSL
ITLKNPVNFGNKENDPVKIVVSLCAIDHSSHLKALSELVELLGDENTVKTICEANDVEEVVNLIK
>Mature_705_residues
MKEVIIITLNERCTQILIRLINSNAPIKISDLAKIFNVSSRTIRYDLDTIDEFLKYNNLPQLIRKPNVGVKFSELLEYRN
KVLSLLDNLNIYYYNLSQKERVNIILSELIQQKDYITINSIADKLMVSRSTIIKDLKDVREWLTRHGLQLKSAPKYGIKV
VGDEKRLRRAAIELLTEAIDVDKALDIVKSPIYTRSSVGIDKQITKLFEDIDIPYIEECIQIAERELETVFSDAAFSGLV
IHIAIAIKRIQLGKDIIMPKEELKALEITKEFAVASNIAKMLEDHFKVSIPLDEIGYITVHLLGSNVSKTRPYPNENWVE
YQLLTEKIITNVTNKIHQDLSGDRQLFEGLLDHLRPTVYRLKHGLKLKNPILDEIKANYKELFEIVKESLKPLEDYTGKA
LNDEEIGYFTIHFGAAIERLKVTKAPKPNILVVCGTGIGTAKLLSSRLQSVFDVNIVDAVAYHQVKERLKEKDIDLIVST
VPIPYEGIKTIEVNPLLTEKDIELLKDLVIKPKLQGTVINDLIKIIEKHCVIGNREKLIEDLSKFLNVASYENTRGVVQP
VLKDLLTKDTIKLNVEAKDWEEAVRIGGELLEKSGAIEPRYIDAMINTVKEIGPYIVIAPGIAMPHARPEAGAKKIGMSL
ITLKNPVNFGNKENDPVKIVVSLCAIDHSSHLKALSELVELLGDENTVKTICEANDVEEVVNLIK

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI2367359, Length=145, Percent_Identity=43.448275862069, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790755, Length=129, Percent_Identity=35.6589147286822, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1789302, Length=115, Percent_Identity=42.6086956521739, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790027, Length=141, Percent_Identity=30.4964539007092, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 79692; Mature: 79692

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVIIITLNERCTQILIRLINSNAPIKISDLAKIFNVSSRTIRYDLDTIDEFLKYNNLP
CCCEEEEEECHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCH
QLIRKPNVGVKFSELLEYRNKVLSLLDNLNIYYYNLSQKERVNIILSELIQQKDYITINS
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEHHH
IADKLMVSRSTIIKDLKDVREWLTRHGLQLKSAPKYGIKVVGDEKRLRRAAIELLTEAID
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
VDKALDIVKSPIYTRSSVGIDKQITKLFEDIDIPYIEECIQIAERELETVFSDAAFSGLV
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHIAIAIKRIQLGKDIIMPKEELKALEITKEFAVASNIAKMLEDHFKVSIPLDEIGYITV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHCCEEEE
HLLGSNVSKTRPYPNENWVEYQLLTEKIITNVTNKIHQDLSGDRQLFEGLLDHLRPTVYR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKHGLKLKNPILDEIKANYKELFEIVKESLKPLEDYTGKALNDEEIGYFTIHFGAAIERL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHH
KVTKAPKPNILVVCGTGIGTAKLLSSRLQSVFDVNIVDAVAYHQVKERLKEKDIDLIVST
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHEEEEE
VPIPYEGIKTIEVNPLLTEKDIELLKDLVIKPKLQGTVINDLIKIIEKHCVIGNREKLIE
CCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
DLSKFLNVASYENTRGVVQPVLKDLLTKDTIKLNVEAKDWEEAVRIGGELLEKSGAIEPR
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHH
YIDAMINTVKEIGPYIVIAPGIAMPHARPEAGAKKIGMSLITLKNPVNFGNKENDPVKIV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCHHHHH
VSLCAIDHSSHLKALSELVELLGDENTVKTICEANDVEEVVNLIK
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHC
>Mature Secondary Structure
MKEVIIITLNERCTQILIRLINSNAPIKISDLAKIFNVSSRTIRYDLDTIDEFLKYNNLP
CCCEEEEEECHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCH
QLIRKPNVGVKFSELLEYRNKVLSLLDNLNIYYYNLSQKERVNIILSELIQQKDYITINS
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCEEHHH
IADKLMVSRSTIIKDLKDVREWLTRHGLQLKSAPKYGIKVVGDEKRLRRAAIELLTEAID
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
VDKALDIVKSPIYTRSSVGIDKQITKLFEDIDIPYIEECIQIAERELETVFSDAAFSGLV
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHIAIAIKRIQLGKDIIMPKEELKALEITKEFAVASNIAKMLEDHFKVSIPLDEIGYITV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHCCEEEE
HLLGSNVSKTRPYPNENWVEYQLLTEKIITNVTNKIHQDLSGDRQLFEGLLDHLRPTVYR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKHGLKLKNPILDEIKANYKELFEIVKESLKPLEDYTGKALNDEEIGYFTIHFGAAIERL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHH
KVTKAPKPNILVVCGTGIGTAKLLSSRLQSVFDVNIVDAVAYHQVKERLKEKDIDLIVST
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHEEEEE
VPIPYEGIKTIEVNPLLTEKDIELLKDLVIKPKLQGTVINDLIKIIEKHCVIGNREKLIE
CCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
DLSKFLNVASYENTRGVVQPVLKDLLTKDTIKLNVEAKDWEEAVRIGGELLEKSGAIEPR
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHH
YIDAMINTVKEIGPYIVIAPGIAMPHARPEAGAKKIGMSLITLKNPVNFGNKENDPVKIV
HHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCHHHHH
VSLCAIDHSSHLKALSELVELLGDENTVKTICEANDVEEVVNLIK
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]