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The map label for this gene is sbcD [H]

Identifier: 167038873

GI number: 167038873

Start: 212353

End: 213570

Strand: Direct

Name: sbcD [H]

Synonym: Teth514_0204

Alternate gene names: 167038873

Gene position: 212353-213570 (Clockwise)

Preceding gene: 167038872

Following gene: 167038874

Centisome position: 8.64

GC content: 35.8

Gene sequence:

>1218_bases
ATGAAGATTTTACATACTTCAGACTGGCATTTAGGGAAGGCTCTTGAAAATTTTTCGAGGATTGAAGAGCAGGAGAAATT
TTTAGAGGATTTTGTTAATATAGTTGAGGAAAATGATGTGGATTTGGTTATAATTGCTGGAGATGTTTATGATTCTTTTA
ATCCTCCTGCAAAAGCGGAAACCCTTTTTTACAACACTTTAAAAAAGCTTTCTAATGGAAATAGGGTGGTTTTGGTTATA
GCAGGGAATCATGACAATCCTGAAAGGCTTTCTGCTGCCAGCCCTCTTGCCTATGACCAAGGTGTTATACTTTTAGGGAT
ACCCAAAAGCATTGTGCCTACTGGGGATTTTGGAAAGTTTAAAATTTTAGACTCTGGTGAAGGCTTTTTTGAAATAGAAA
TAAAAGGAGAAAAAGCGGTAATTATAGCTTTGCCGTATCCCAGCGAAAAAAGGCTAAATGAAATTTTTACAGCGGAATTG
GATGAAGAGAAAAGACAGAAAAGTTACTCTGAAAGAGTTGGTGAAATTTTTAATGACCTTTCTAAAAAATACAGAGAAGA
TACTATAAACATTGCGGTATCTCATATTTTTGTTGCAGGAGGAGAGGAGTCAGGTTCAGAAAGGCCCATTCAGTTAGGAG
GAAGTTTTACAGTAGAAATAAGGCACCTGCCACAAAAAGCGCAGTACATAGCTCTCGGACACCTTCACAAACCCCAGAGA
ATTTCTTCTACTCTTCCTGCTTATTATTCTGGTTCCCCTCTTCAGTACAGCAAAAGTGAGATGAACCATTCTAAATGTGC
TTATTTAGTAGATTTAAAGGCAGGAGAACCTGCACTTGTGAAGGAAATATATTTTAAAAATTACAAGCCTATTGAAGTGT
TTAGGTGTAATGGTATAGAGGAAGCTTTAGAGATTTGCAATGAATACAGGGATAAAGATATATGGGCATATTTCGAGATT
AAAACTGAGTTTCCACTGCCTTCTTCAAAGATAAAAGAAATGAAGAGCATATTACCGGATATAGTTGAAATAAAGCCAAT
TTTGCCAGAGGATGAGATGGAAATTGAAGACTATGAGATAGATGATAAAAGTGTAAAGGAACTTTTTGAAGAATTTTATT
TAAAGGAAAACAAAGTTTCTCCAACAGAGGAGGTTTTAGAACTTTTTATGAGTATAGTAAAGGAAGAGGATGAGGAAGAT
GAGACCTCTGAAGCTTAA

Upstream 100 bases:

>100_bases
GGAACCGTCCCCTCTGTTTGGTATAAGTTTTATGATATAATAAGCTTGTAACAATTGTTTATCGTTTCTAAGTGAAAGAT
AAAATATTAAGGGTGATAAA

Downstream 100 bases:

>100_bases
AATTGCTGGGCTTAATAGTTTTGTAGAAGAACAAATTATTGATTTTGAACTCCTAACAGAAAAAGGACTTTTTGGCATAT
TTGGTCCCACAGGAAGTGGA

Product: nuclease SbcCD subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKILHTSDWHLGKALENFSRIEEQEKFLEDFVNIVEENDVDLVIIAGDVYDSFNPPAKAETLFYNTLKKLSNGNRVVLVI
AGNHDNPERLSAASPLAYDQGVILLGIPKSIVPTGDFGKFKILDSGEGFFEIEIKGEKAVIIALPYPSEKRLNEIFTAEL
DEEKRQKSYSERVGEIFNDLSKKYREDTINIAVSHIFVAGGEESGSERPIQLGGSFTVEIRHLPQKAQYIALGHLHKPQR
ISSTLPAYYSGSPLQYSKSEMNHSKCAYLVDLKAGEPALVKEIYFKNYKPIEVFRCNGIEEALEICNEYRDKDIWAYFEI
KTEFPLPSSKIKEMKSILPDIVEIKPILPEDEMEIEDYEIDDKSVKELFEEFYLKENKVSPTEEVLELFMSIVKEEDEED
ETSEA

Sequences:

>Translated_405_residues
MKILHTSDWHLGKALENFSRIEEQEKFLEDFVNIVEENDVDLVIIAGDVYDSFNPPAKAETLFYNTLKKLSNGNRVVLVI
AGNHDNPERLSAASPLAYDQGVILLGIPKSIVPTGDFGKFKILDSGEGFFEIEIKGEKAVIIALPYPSEKRLNEIFTAEL
DEEKRQKSYSERVGEIFNDLSKKYREDTINIAVSHIFVAGGEESGSERPIQLGGSFTVEIRHLPQKAQYIALGHLHKPQR
ISSTLPAYYSGSPLQYSKSEMNHSKCAYLVDLKAGEPALVKEIYFKNYKPIEVFRCNGIEEALEICNEYRDKDIWAYFEI
KTEFPLPSSKIKEMKSILPDIVEIKPILPEDEMEIEDYEIDDKSVKELFEEFYLKENKVSPTEEVLELFMSIVKEEDEED
ETSEA
>Mature_405_residues
MKILHTSDWHLGKALENFSRIEEQEKFLEDFVNIVEENDVDLVIIAGDVYDSFNPPAKAETLFYNTLKKLSNGNRVVLVI
AGNHDNPERLSAASPLAYDQGVILLGIPKSIVPTGDFGKFKILDSGEGFFEIEIKGEKAVIIALPYPSEKRLNEIFTAEL
DEEKRQKSYSERVGEIFNDLSKKYREDTINIAVSHIFVAGGEESGSERPIQLGGSFTVEIRHLPQKAQYIALGHLHKPQR
ISSTLPAYYSGSPLQYSKSEMNHSKCAYLVDLKAGEPALVKEIYFKNYKPIEVFRCNGIEEALEICNEYRDKDIWAYFEI
KTEFPLPSSKIKEMKSILPDIVEIKPILPEDEMEIEDYEIDDKSVKELFEEFYLKENKVSPTEEVLELFMSIVKEEDEED
ETSEA

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=356, Percent_Identity=27.5280898876405, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46198; Mature: 46198

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILHTSDWHLGKALENFSRIEEQEKFLEDFVNIVEENDVDLVIIAGDVYDSFNPPAKAE
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHH
TLFYNTLKKLSNGNRVVLVIAGNHDNPERLSAASPLAYDQGVILLGIPKSIVPTGDFGKF
HHHHHHHHHHCCCCEEEEEEECCCCCHHHHHCCCCCEECCCEEEEECCHHHCCCCCCCEE
KILDSGEGFFEIEIKGEKAVIIALPYPSEKRLNEIFTAELDEEKRQKSYSERVGEIFNDL
EEEECCCCEEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SKKYREDTINIAVSHIFVAGGEESGSERPIQLGGSFTVEIRHLPQKAQYIALGHLHKPQR
HHHHHHHHHEEEEEEEEEECCCCCCCCCCEEECCEEEEEEEECCCCCCEEEECCCCCCHH
ISSTLPAYYSGSPLQYSKSEMNHSKCAYLVDLKAGEPALVKEIYFKNYKPIEVFRCNGIE
HHHCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHH
EALEICNEYRDKDIWAYFEIKTEFPLPSSKIKEMKSILPDIVEIKPILPEDEMEIEDYEI
HHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCC
DDKSVKELFEEFYLKENKVSPTEEVLELFMSIVKEEDEEDETSEA
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKILHTSDWHLGKALENFSRIEEQEKFLEDFVNIVEENDVDLVIIAGDVYDSFNPPAKAE
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHH
TLFYNTLKKLSNGNRVVLVIAGNHDNPERLSAASPLAYDQGVILLGIPKSIVPTGDFGKF
HHHHHHHHHHCCCCEEEEEEECCCCCHHHHHCCCCCEECCCEEEEECCHHHCCCCCCCEE
KILDSGEGFFEIEIKGEKAVIIALPYPSEKRLNEIFTAELDEEKRQKSYSERVGEIFNDL
EEEECCCCEEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SKKYREDTINIAVSHIFVAGGEESGSERPIQLGGSFTVEIRHLPQKAQYIALGHLHKPQR
HHHHHHHHHEEEEEEEEEECCCCCCCCCCEEECCEEEEEEEECCCCCCEEEECCCCCCHH
ISSTLPAYYSGSPLQYSKSEMNHSKCAYLVDLKAGEPALVKEIYFKNYKPIEVFRCNGIE
HHHCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHH
EALEICNEYRDKDIWAYFEIKTEFPLPSSKIKEMKSILPDIVEIKPILPEDEMEIEDYEI
HHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCC
DDKSVKELFEEFYLKENKVSPTEEVLELFMSIVKEEDEEDETSEA
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 10568751; 1646786; 8493111 [H]