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The map label for this gene is eutB

Identifier: 16519956

GI number: 16519956

Start: 182109

End: 183107

Strand: Reverse

Name: eutB

Synonym: NGR_a01490

Alternate gene names: 16519956

Gene position: 183107-182109 (Counterclockwise)

Preceding gene: 16519955

Following gene: 16519957

Centisome position: 34.15

GC content: 57.36

Gene sequence:

>999_bases
GTGAATGAATTGTCGAACTTAAGTCTAGAATCGATCGAGCGAGCGCGTGAGCGGATCGAAGAGCACGTCTTCCGTACCCC
TCTGACGACATCAAGGTCGCTAACCGAACTTACCGGAACTCAGGTCAGCCTCAAGCTCGAGCACTATCAGCGCACTGGTA
GCTTTAAGCTGCGGGGTGCGACAAACGCAATTCTTCAACTCAGCCCGTCGGATCGGGCACGTGGGGTTATTGCGGCATCT
ACGGGCAATCACGGACGGGCTCTTTCCTACGCCGCAAAAGCGGTCGGCTCTCGCGCCACCATCTGCATGTCGGATCTTGT
TCCAGAAAACAAGGTTTCCGAGATCCGGAAGCTTGGCGCGACAGTTCGGATAGTGGGATCGTCACAAGACGATGCGCAAG
TCGAAGTCGAGCGGCTCGTCGCGGAGGAAGGCCTCAGCATGATCCCGCCTTTCGATCACCCGCATATCATCGCCGGCCAG
CGAACCGTCGGTCTTGAGATCGTTGAGGCGATGCCGGACGTCGCGATGGTACTGCTTCCACTGTCGGGTGGCGGCTTGGC
TGCAGGCGTTGCAGCAGCGGTGAAGGCACTGCGGCCTCATGCGAGGATCATCGGTGTCACTATGGATCGAGGCGCCGCGA
TGAAGGCCAGCATCGAAGCTGGGCATCCGGTACAAGTGAAGGAGTATCGGAGCTTGGCTGATTCTTTAGGTGGAGGAATC
GGCATGGCCAACGCTTGGACCTTTCAAATGTGCAGAGCCCTTCTGGACGATGTTGTCCTCGTTAATGAAGGCGAAATAGC
CGCGGGAATTAGACATGCTTATGAGCATGAGCGTCAGATACTCGAGGGCGCCGGCGCTGTCGGTATCGCAGCGCTTCTCT
CCGGCAAGGTGGCTGCTCGCGGAGGTTCAGTAGGAGTCGTTTTGTCAGGTCAAAACATCGACATGGGCCTGCATCGGGAG
GTCATTAACGGAGTTGTCAGAGCGACCGAGGAGGATTGA

Upstream 100 bases:

>100_bases
CCCGACGACCGAACTTGCTGTGAAGTATTGTTTCGATTTGCTGCATGGGCAGTCTGCACGTTGATCGACTTGTATGCCAG
GATGTTTGCCACTGTATTAG

Downstream 100 bases:

>100_bases
TGCCTACAATGAAAATACTCACTGAGGGGGAGTTGAGGCAAATCGTGCCGCTCGACCTCGACGCGGTTAAGTGCACCGAA
GACGCTTTCCGCGCACTCGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MNELSNLSLESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGATNAILQLSPSDRARGVIAAS
TGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGATVRIVGSSQDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQ
RTVGLEIVEAMPDVAMVLLPLSGGGLAAGVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGI
GMANAWTFQMCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGIAALLSGKVAARGGSVGVVLSGQNIDMGLHRE
VINGVVRATEED

Sequences:

>Translated_332_residues
MNELSNLSLESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGATNAILQLSPSDRARGVIAAS
TGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGATVRIVGSSQDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQ
RTVGLEIVEAMPDVAMVLLPLSGGGLAAGVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGI
GMANAWTFQMCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGIAALLSGKVAARGGSVGVVLSGQNIDMGLHRE
VINGVVRATEED
>Mature_332_residues
MNELSNLSLESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGATNAILQLSPSDRARGVIAAS
TGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGATVRIVGSSQDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQ
RTVGLEIVEAMPDVAMVLLPLSGGGLAAGVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGI
GMANAWTFQMCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGIAALLSGKVAARGGSVGVVLSGQNIDMGLHRE
VINGVVRATEED

Specific function: Acts On Both Serine And Threonine, And Properly Considered As A Hydroxy Amino Acid Deaminase. [C]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=33.3333333333333, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=30.794701986755, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33469958, Length=152, Percent_Identity=34.8684210526316, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789505, Length=260, Percent_Identity=36.1538461538462, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=34.0136054421769, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71991565, Length=310, Percent_Identity=38.7096774193548, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=311, Percent_Identity=38.9067524115756, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=318, Percent_Identity=28.6163522012579, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320930, Length=315, Percent_Identity=34.9206349206349, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355833, Length=309, Percent_Identity=39.1585760517799, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24645328, Length=213, Percent_Identity=39.4366197183099, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4TJ_RHISN (P55664)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_444076.1
- ProteinModelPortal:   P55664
- SMR:   P55664
- GeneID:   962446
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a01490
- HOGENOM:   HBG714501
- ProtClustDB:   PRK07476
- InterPro:   IPR014333
- InterPro:   IPR001926
- InterPro:   IPR000634
- TIGRFAMs:   TIGR02991

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.3.1.19

Molecular weight: Translated: 35071; Mature: 35071

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELSNLSLESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEEEHHHCCCCEEEECC
TNAILQLSPSDRARGVIAASTGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGA
CCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHCCC
TVRIVGSSQDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQRTVGLEIVEAMPDVAMVLLP
EEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEE
LSGGGLAAGVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGI
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCEEHHHHHHHHHHHCCCC
GMANAWTFQMCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGIAALLSGKVAAR
CCCHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEC
GGSVGVVLSGQNIDMGLHREVINGVVRATEED
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNELSNLSLESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEEEEEEHHHCCCCEEEECC
TNAILQLSPSDRARGVIAASTGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGA
CCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEHHHCCCCHHHHHHHHCCC
TVRIVGSSQDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQRTVGLEIVEAMPDVAMVLLP
EEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEE
LSGGGLAAGVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGI
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCEEHHHHHHHHHHHCCCC
GMANAWTFQMCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGIAALLSGKVAAR
CCCHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEC
GGSVGVVLSGQNIDMGLHREVINGVVRATEED
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424