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The map label for this gene is uvrB [H]

Identifier: 16273166

GI number: 16273166

Start: 1322490

End: 1324529

Strand: Reverse

Name: uvrB [H]

Synonym: HI1247

Alternate gene names: 16273166

Gene position: 1324529-1322490 (Counterclockwise)

Preceding gene: 16273167

Following gene: 16273163

Centisome position: 72.37

GC content: 39.8

Gene sequence:

>2040_bases
ATGTCTGAAAAAATCAACACAAAACCATTCATTCTGCATTCCGACTTTCGTCCCTCTGGCGATCAGCCACAAGCTATCGA
AAAATTGGCTGAAAATTTAACGGATGGTTTGGCTCACCAAACTTTGCTCGGTGTAACTGGCTCGGGGAAAACCTTTACTA
TCGCCAATGTAATCGCTCAATTAAATCGCCCTGCGATGTTACTTGCACCGAATAAAACCCTTGCTGCCCAGCTTTATGCA
GAAATGAAAGCTTTTTTTCCAGAAAATGCGGTGGAATATTTTGTGTCTTACTATGATTATTATCAGCCAGAAGCCTATGT
GCCAAGCAGTGATACATTTATTGAAAAAGATGCGTCTATTAATGATCAAATTGAACAAATGCGACTTTCTGCGACGAAAT
CTTTTCTAGAACGTCGAGATACCATCGTGGTGGCTTCTGTTTCTGCAATTTATGGTTTGGGCGATCCTGATAGCTATTTA
CAAATGATGTTGCATTTACAACAAGGTGCCATTATCGATCAACGCCAAATTTTAGCGAAATTAGCGGAATTACAATATAC
CCGAAATGATCAAGCATTTCAGCGTGGAACTTTCCGTGTTCGCGGAGAAATTATTGATATTTTCCCTGCGGAATCTGATG
ATCGTGCGGTGCGTATTGAATTATTTGATGATGAAATCGAGCGTTTAAGTTTATTTGATCCGCTCACTGGTAGTAGTTTT
GGTGCTGTACCACGTTTTACGATCTATCCTAAAACTCACTATGTGACGCCAAGAGAACGTATTTTAGATGCGATAGAAAA
CATCAAAAAAGAACTGGTATCACGCCGTGAATACTTCATTAAAGAACATAAACTTTTAGAAGAACAGCGTATCAGCCAAC
GAACCCAATTTGATATTGAAATGATGAATGAATTGGGCTATTGCTCGGGAATTGAAAACTACTCTCGCTATTTATCGGGA
AGAAATGAGGGCGAACCACCACCAACATTATTTGATTATATGCCCCCTGATGCCATTTTAATTATTGATGAATCTCATGT
AACTGTGCCTCAAATTGGCGGGATGTATCGTGGCGACCGTTCACGTAAAGAAACCTTAGTCGAATATGGTTTCCGTTTGC
CGTCCGCATTGGATAATCGTCCGTTACGCTTTGAGGAATTTGAACGCTTAGCTCCGCAAACCATCTATGTTTCCGCAACA
CCAGGGGCCTATGAATTAGAGAAATCAGGTAGTGAAATCATCGATCAAGTGGTTCGCCCGACAGGTTTGCTTGATCCGCT
TATTGAAATTCGTCCAGTGTCAATTCAAGTGGATGATTTACTTTCCGAAGCTCGCCAAAGAGCGGATAAAAATGAGCGAG
TTTTAGTCACTACACTCACTAAAAAAATGGCGGAAGATTTAACGGATTATTTAGATGAACACGGGATTCGTGTGCGTTAT
CTACATTCTGATATTGATACCGTGGAACGCGTCGAAATTATCCGTGATTTGCGTTTAGGCGAATTTGATGTATTAGTGGG
AATTAACTTATTGCGTGAAGGTTTAGATATTCCAGAAGTGTCTCTTGTGGCGATTTTAGATGCTGACAAAGAAGGATTTT
TACGCTCCGAACGTTCTTTAATTCAAACCATCGGCCGTGCTGCACGAAACTTAAATGGTAAAGCGATTTTATATGCGGAT
AGCATCACAAAATCCATGGAAAAAGCCATCACCGAAACCAATCGTCGTCGTGAAAAACAAACAAAATACAATGAAGAACA
TGGCATTGTGCCACAGGCATTAAATAAGAAAGTCGGTGAATTATTAGATATTGGGCAAGGTGCAAACCAAAAAGCGAAAG
CCAATAAACAACGTGGAAAAATGGCGGCAGAACCAACCGCACTTTATAATGCACCGAAAAATGCCAAAGAATATCAACAA
CAAATCAAAAAATTGGAACAACAAATGTATAAATTTGCGCAAGATTTGGAATTTGAAAAAGCTGCGGCTATTCGCGATCA
ATTACATCAATTACGTGAACAGTTTGTTTTTGATAACTAA

Upstream 100 bases:

>100_bases
TAAGTCTGTGTAAAACTTAGATTTTTGCCTGATCAATTTTACACAGTAAATATGCTAAAATAGGCATTATTCAAAACTAT
CAAAAAACCGACCGCACTTT

Downstream 100 bases:

>100_bases
AAGAAACGCCAGCTTAAGCTGGCGTTCTGTCTATTTATTTTCACCTGAAGAATACAAGCGATTTTTATATAAATAACTAC
CTAATAAAGCGTGAGCCAAT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYA
EMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYL
QMMLHLQQGAIIDQRQILAKLAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSF
GAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIEMMNELGYCSGIENYSRYLSG
RNEGEPPPTLFDYMPPDAILIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSAT
PGAYELEKSGSEIIDQVVRPTGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYAD
SITKSMEKAITETNRRREKQTKYNEEHGIVPQALNKKVGELLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQ
QIKKLEQQMYKFAQDLEFEKAAAIRDQLHQLREQFVFDN

Sequences:

>Translated_679_residues
MSEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYA
EMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYL
QMMLHLQQGAIIDQRQILAKLAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSF
GAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIEMMNELGYCSGIENYSRYLSG
RNEGEPPPTLFDYMPPDAILIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSAT
PGAYELEKSGSEIIDQVVRPTGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYAD
SITKSMEKAITETNRRREKQTKYNEEHGIVPQALNKKVGELLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQ
QIKKLEQQMYKFAQDLEFEKAAAIRDQLHQLREQFVFDN
>Mature_678_residues
SEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAE
MKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLQ
MMLHLQQGAIIDQRQILAKLAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSFG
AVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIEMMNELGYCSGIENYSRYLSGR
NEGEPPPTLFDYMPPDAILIIDESHVTVPQIGGMYRGDRSRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATP
GAYELEKSGSEIIDQVVRPTGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRYL
HSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYADS
ITKSMEKAITETNRRREKQTKYNEEHGIVPQALNKKVGELLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQQ
IKKLEQQMYKFAQDLEFEKAAAIRDQLHQLREQFVFDN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=672, Percent_Identity=77.6785714285714, Blast_Score=1061, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.4527687296417, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77527; Mature: 77396

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQ
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHH
LNRPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASI
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLQMMLHLQQGAIIDQRQILAK
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
LAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSF
HHHHHHCCCCHHHHCCCEEEECEEEEEECCCCCCCEEEEEEECHHHHHHHHCCCCCCCCC
GAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMNELGYCSGIENYSRYLSGRNEGEPPPTLFDYMPPDAILIIDESHVTVPQIGGMYRGDR
HHHHCHHHCCHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGAYELEKSGSEIIDQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCHHCCHHHHHHHHHCC
TGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
CCCCCCHHHEEECEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLNGKAILYADSITKSMEKAITETNRRREKQTKYNEEHGIVPQALNKKVGE
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQQIKKLEQQMYKFAQDLEFEK
HHHCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
AAAIRDQLHQLREQFVFDN
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQ
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHH
LNRPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASI
CCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLQMMLHLQQGAIIDQRQILAK
HHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
LAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSF
HHHHHHCCCCHHHHCCCEEEECEEEEEECCCCCCCEEEEEEECHHHHHHHHCCCCCCCCC
GAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIE
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMNELGYCSGIENYSRYLSGRNEGEPPPTLFDYMPPDAILIIDESHVTVPQIGGMYRGDR
HHHHCHHHCCHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKETLVEYGFRLPSALDNRPLRFEEFERLAPQTIYVSATPGAYELEKSGSEIIDQVVRP
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCHHCCHHHHHHHHHCC
TGLLDPLIEIRPVSIQVDDLLSEARQRADKNERVLVTTLTKKMAEDLTDYLDEHGIRVRY
CCCCCCHHHEEECEEEHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEE
LHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSL
ECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHH
IQTIGRAARNLNGKAILYADSITKSMEKAITETNRRREKQTKYNEEHGIVPQALNKKVGE
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LLDIGQGANQKAKANKQRGKMAAEPTALYNAPKNAKEYQQQIKKLEQQMYKFAQDLEFEK
HHHCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
AAAIRDQLHQLREQFVFDN
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA