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The map label for this gene is wecB

Identifier: 162419624

GI number: 162419624

Start: 537821

End: 538951

Strand: Direct

Name: wecB

Synonym: YpAngola_A0514

Alternate gene names: 162419624

Gene position: 537821-538951 (Clockwise)

Preceding gene: 292659867

Following gene: 162418232

Centisome position: 11.94

GC content: 50.13

Gene sequence:

>1131_bases
GTGAAAGTGTTGACTGTTTTTGGCACCCGTCCTGAAGCGATAAAGATGGCTCCTCTGGTGCATGCCTTGGCTCAGGATGA
CGCCTTTGAATCGAGAGTCTGCGTAACGGCCCAGCATCGTGAGATGCTGGATCAGGTATTGCGTTTATTTGAGATTCAAC
CAGATTATGATTTAGACATCATGAGGCCAGGACAGGGATTGACGGAAATAACCTGCCGCATTCTGGAAGGGCTAAAGCCG
GTTCTCGAAGAGTTTAAGCCGGATGTTATCTTGGTGCATGGCGATACCACAACCACACTGTCGGCCAGTCTGGCCGGGTT
CTATCACCGCATACCTGTCGGCCATGTCGAGGCTGGGCTGCGGACCGGGGATCTCTATTCTCCATGGCCGGAGGAAGCTA
ACCGTCAACTGACTGGGCATCTTGCCATGTATCATTTTGCGCCGACCGAGAATTCTCGACAGAATTTGCTACGTGAATGG
GTGCCGGAGAACCGTATTTTTGTCACGGGTAATACGGTGATTGATGCGTTGTTCTGGGTCCGTGATCGGGTGATGAATAC
CCCTGATTTGCGAGCAAACTTGGCACAACGTTACGCCTTCCTTGATACCAATAAGAAGATGATTCTGGTTACTGGCCATC
GTCGTGAAAGCTTTGGTGGTGGTTTTGAGCGGATTTGCAGTGCGTTAGCGGAAATTGCCCGGAAACATCCCGAGGTGCAG
GTTGTTTATCCCGTGCATCTTAACCCCAACGTCAGCGAGCCGGTAAACCGTATCTTGAAGGGGATTGATAATATTATTCT
GATCGATCCGCAAGACTACCTGCCATTTGTTTACCTAATGAATCATGCGTATCTGATCCTGACTGACTCAGGGGGTATTC
AGGAAGAAGCGCCGTCATTGGGTAAACCTGTCTTGGTGATGCGTGACACCACCGAGCGCCCGGAAGCCGTAGATTCTGGC
ACTGTGCTGCTGGTGGGGACAAATATTAATAAAATTGTTGATGCAGTAACCCGCTTGCTGACTGATGAGACGGCTTATCA
TCAAATGACCCGGGCACACAATCCTTACGGTGACGGGTATGCCTGTCAACGCATCCTTAAAGCTTTAAAGAATCATCAGG
TGACGCTATGA

Upstream 100 bases:

>100_bases
TATCGAGTCACGCACTGAGCGACAAGAAATCGTTAATGGACGCATTGTGCGCCCAACTTGCAGGCATTGCCTGCGGCTAA
CTGACCTAAAGAGATTCACT

Downstream 100 bases:

>100_bases
GTTTTGAAACTATTTCTGTTATCGGTCTTGGGTATATTGGTCTGCCGACCGCGGCGGCTTTTGCTTCGCGTAAAAAGAAA
GTGATTGGCGTTGACGTCAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREW
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Sequences:

>Translated_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREW
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL
>Mature_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREW
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=78.7234042553192, Blast_Score=606, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECB_YERPE (Q8ZAE3)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0470
- RefSeq:   NP_667702.1
- RefSeq:   NP_994472.1
- RefSeq:   YP_002348742.1
- ProteinModelPortal:   Q8ZAE3
- SMR:   Q8ZAE3
- GeneID:   1145311
- GeneID:   1176703
- GeneID:   2765332
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3864
- KEGG:   ypk:y0364
- KEGG:   ypm:YP_3181
- HOGENOM:   HBG405561
- OMA:   YYHQIPV
- ProtClustDB:   CLSK889579
- BioCyc:   YPES187410:Y0364-MONOMER
- BioCyc:   YPES214092:YPO3864-MONOMER
- BRENDA:   5.1.3.14
- GO:   GO:0005737
- InterPro:   IPR003331
- PANTHER:   PTHR18964:SF2
- TIGRFAMs:   TIGR00236

Pfam domain/function: PF02350 Epimerase_2

EC number: =5.1.3.14

Molecular weight: Translated: 42379; Mature: 42379

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: ACT_SITE 213-213

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEE
MRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREWVPENRIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
HHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCCEEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGY
CCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
ACQRILKALKNHQVTL
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEE
MRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREWVPENRIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
HHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCCEEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGY
CCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
ACQRILKALKNHQVTL
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430