Click here to switch to the map view.

The map label for this gene is tauD [C]

Identifier: 162149227

GI number: 162149227

Start: 3557148

End: 3558104

Strand: Direct

Name: tauD [C]

Synonym: GDI_3459

Alternate gene names: 162149227

Gene position: 3557148-3558104 (Clockwise)

Preceding gene: 162149222

Following gene: 162149231

Centisome position: 90.19

GC content: 63.53

Gene sequence:

>957_bases
ATGTCTTTCCATCCGCAGCCCTCTCCAGCCCGCCCCACCCTGACCCGCCTGGGTGGAAATATCGGTGCCGAAATCCACGG
GATCACGCTCTCGCCCGACCTGTCGGAGCAGGATGTCGCCTTTGTCTACAAGGCCATGCTCGAGTACAAGGTGATCTTCT
TCCGCCAGCAGTCACTCGACAGCGCCGGTCAGGAACAGCTTGGCGCACGTTTCGGCACGCTGGTCGCTCATCCCACCGTG
GCCAGCGCGAAGGGCACGAACCATATTTTCGAGCTCAAGGCGCAGAAGGGGCGGGCCGCCAACACCTGGCACGCCGACAT
GACGTTCATGGCCACCTACCCCAAGGCGTCCATCCTGCGCTCGGTCCATACCGCGCCCTATGGCGGGGCGACGCTGTGGG
CCAATACCGCCACCGCGTACCAGGCCCTGCCCCAACCGTTGCAGGAACTGGCCGACAAGCTGTGGGCGATCCATACCAAT
GACGATTACGATCACACGGACCTTGTCGTGGAACGCGACTGGGACTTCATCCGCTGGTCGGCCAACGTGTTCGCCGCGCG
CATCTTCGAAACCCGCCACCCTCTGGTGCGCGTCCATCCCGAGACAGGCGAAAAGAGCCTTATCCTGGGCAACTTCGTCA
AACGGCTGGTGGACTTCAACCTGCCGGATTCCCGCGCGCTGCTGGACCTGTTCCTGTCCTACGTCACGCGGCCGGAAAAC
ACGATCACATGGCACTGGCAGCCCGGCGACGTCGCGATGTGGGATAATCGCGCGGCCCTGCACCGTGCCATTGCCGATTT
CGGCGATCATCCCCGCGAACTGCAACGGGTCACGCTGGTGGGCGATACGCCTGTCAGTGTCGATGGACGCAAAAGCGAGC
AGATCATCGACGGCCAGCCCAATCCCCGCCTCCTGCTCGAAACGCCCTACCACTGGACGGCCCGCGCCGAGGCGTAA

Upstream 100 bases:

>100_bases
GTTAAGTTATTCTTAAATATATAAATTACCGAATATGACGCATGCCGCCCTGGGCAACATTAATACATAATTTTTTCGTT
GTTTATAGGAACCCGGTCCG

Downstream 100 bases:

>100_bases
CCCTCCGCTTCCTGCCAGGGTGCATGATCGAACCGTTCCGGACCGGGAGAACCGGCCGATTAGCCGTCCAAAAAGAAAAG
GGGCGGTGCCGTCGCCGGCA

Product: alpha-ketoglutarate-dependent taurine dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSFHPQPSPARPTLTRLGGNIGAEIHGITLSPDLSEQDVAFVYKAMLEYKVIFFRQQSLDSAGQEQLGARFGTLVAHPTV
ASAKGTNHIFELKAQKGRAANTWHADMTFMATYPKASILRSVHTAPYGGATLWANTATAYQALPQPLQELADKLWAIHTN
DDYDHTDLVVERDWDFIRWSANVFAARIFETRHPLVRVHPETGEKSLILGNFVKRLVDFNLPDSRALLDLFLSYVTRPEN
TITWHWQPGDVAMWDNRAALHRAIADFGDHPRELQRVTLVGDTPVSVDGRKSEQIIDGQPNPRLLLETPYHWTARAEA

Sequences:

>Translated_318_residues
MSFHPQPSPARPTLTRLGGNIGAEIHGITLSPDLSEQDVAFVYKAMLEYKVIFFRQQSLDSAGQEQLGARFGTLVAHPTV
ASAKGTNHIFELKAQKGRAANTWHADMTFMATYPKASILRSVHTAPYGGATLWANTATAYQALPQPLQELADKLWAIHTN
DDYDHTDLVVERDWDFIRWSANVFAARIFETRHPLVRVHPETGEKSLILGNFVKRLVDFNLPDSRALLDLFLSYVTRPEN
TITWHWQPGDVAMWDNRAALHRAIADFGDHPRELQRVTLVGDTPVSVDGRKSEQIIDGQPNPRLLLETPYHWTARAEA
>Mature_317_residues
SFHPQPSPARPTLTRLGGNIGAEIHGITLSPDLSEQDVAFVYKAMLEYKVIFFRQQSLDSAGQEQLGARFGTLVAHPTVA
SAKGTNHIFELKAQKGRAANTWHADMTFMATYPKASILRSVHTAPYGGATLWANTATAYQALPQPLQELADKLWAIHTND
DYDHTDLVVERDWDFIRWSANVFAARIFETRHPLVRVHPETGEKSLILGNFVKRLVDFNLPDSRALLDLFLSYVTRPENT
ITWHWQPGDVAMWDNRAALHRAIADFGDHPRELQRVTLVGDTPVSVDGRKSEQIIDGQPNPRLLLETPYHWTARAEA

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=286, Percent_Identity=34.965034965035, Blast_Score=167, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322971, Length=290, Percent_Identity=25.5172413793103, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 35766; Mature: 35635

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFHPQPSPARPTLTRLGGNIGAEIHGITLSPDLSEQDVAFVYKAMLEYKVIFFRQQSLD
CCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEHHHHC
SAGQEQLGARFGTLVAHPTVASAKGTNHIFELKAQKGRAANTWHADMTFMATYPKASILR
CCCHHHHHHHHHHHEECCCCCCCCCCCEEEEEECCCCCCCCEEECCEEEEEECCHHHHHH
SVHTAPYGGATLWANTATAYQALPQPLQELADKLWAIHTNDDYDHTDLVVERDWDFIRWS
HHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCEEEEH
ANVFAARIFETRHPLVRVHPETGEKSLILGNFVKRLVDFNLPDSRALLDLFLSYVTRPEN
HHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
TITWHWQPGDVAMWDNRAALHRAIADFGDHPRELQRVTLVGDTPVSVDGRKSEQIIDGQP
EEEEEEECCCEEEECCHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCCEECCCC
NPRLLLETPYHWTARAEA
CCEEEEECCCCEEEECCC
>Mature Secondary Structure 
SFHPQPSPARPTLTRLGGNIGAEIHGITLSPDLSEQDVAFVYKAMLEYKVIFFRQQSLD
CCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEHHHHC
SAGQEQLGARFGTLVAHPTVASAKGTNHIFELKAQKGRAANTWHADMTFMATYPKASILR
CCCHHHHHHHHHHHEECCCCCCCCCCCEEEEEECCCCCCCCEEECCEEEEEECCHHHHHH
SVHTAPYGGATLWANTATAYQALPQPLQELADKLWAIHTNDDYDHTDLVVERDWDFIRWS
HHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCEEEEH
ANVFAARIFETRHPLVRVHPETGEKSLILGNFVKRLVDFNLPDSRALLDLFLSYVTRPEN
HHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
TITWHWQPGDVAMWDNRAALHRAIADFGDHPRELQRVTLVGDTPVSVDGRKSEQIIDGQP
EEEEEEECCCEEEECCHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCCEECCCC
NPRLLLETPYHWTARAEA
CCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]