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The map label for this gene is desK [H]

Identifier: 162146989

GI number: 162146989

Start: 1188758

End: 1189864

Strand: Direct

Name: desK [H]

Synonym: GDI_1194

Alternate gene names: 162146989

Gene position: 1188758-1189864 (Clockwise)

Preceding gene: 162146988

Following gene: 162146990

Centisome position: 30.14

GC content: 70.91

Gene sequence:

>1107_bases
TTGACGCCCGCCCCCGCCACACGCAACGATCCGACGATGCACACACGGGGCGAGCGCTGGTGGGAGGGGCCATGGCCCTG
GCTCGTCTACCTGATCTTCTACGTCCTGCCCTGGGCGTGGGAGCCACCCCATGCGACCGACCTGATCGCCTCGGCCATCG
GGCTGGCCGTGTTCCTGCCGGTGTATTTTGTCAGTCACCGCCTCACCGACCTGCCGCTGCTGGCCTGTGCCGGCATCATG
CTGGGCATCGGCATCGCACTCGCCCCGTTCGGCAGCTGGACCGTCTTCCCGATCTACGCCAGCGCCGTGGCCGGCCACCT
GCGACCCGTCCGTTTCGCCGTCGCGACAGTCGCGGCCATTGCCGTCGCGACGGCATTGGCCGGGCTGGCCTGGCACCAGC
CCGTGCTGTGGTGGTTCCCCGGAATCCTGCTTGTCATCATCATCGGCGGCAGCACCATGTCGCGGGTGGCCTTCCATGAA
CGCACCCAGGCCCTGCTGGCCAGCCAGGAAGAAGTCCGCCGCCTTGCCGGGACGGCCGAGCGCGAACGCATCGCGCGTGA
CCTGCACGACGTCATCGGCCGCGCTTTGACCCTGACCGCGCTGAAGGCCGACCTCGCCGCCAGACTCGCCCCCCGGGACG
CCGAGGCCGCCGAAGCCGAGATGCGCGCCGTCGCCGCCCTGGCGCGCGAGGGCCTGGCCGAAATCCGTGCCGCCCTGGCC
GGACACGCCGGAGGAAGCCTGGCGCATGAAATCGCCGCCTCCACCGCCGCCCTTGAAGCCGCGAACATCGCCTCGACCCT
TGCCGGGGACCCCGCCGCCATCCCCGCCGATGCCGGCGCCGTCCTCGCAATGACCCTGCGCGAAGCCGTCACCAACGTCA
TCCGCCACGCCGAAGCCACATGTTGCGTCATTCAGCTGGACCATCACGACGGCACCGCCCGCCTGTCCGTATGCGACAAC
GGCCACGGACGCAGTTTCACGGAAGGACGGGGCCTGACCGGAATGCGCCAGAGGCTGGCGGCCGCGGGCGGCGCGCTGGC
CTTTCAGCCCGGCACGCCGGAGGCCGGCAGGCAGGGCATCCGGCTTGTCGCCACGGTGCCCGCATGA

Upstream 100 bases:

>100_bases
CCGACACGATCGGAACCGTCGCCACGCACGCCGCCGCCCTGCTGGCCATGACAGCCGCCGCCTTCCTCTGGGCCCGGGCC
GGCTGGCGCAGGAGCGCCGC

Downstream 100 bases:

>100_bases
TCCGTCTTGTCATCGCCGAAGACCAGACGCTCGTGCTCGGGGCCATCGCCGCCCTGCTGGAACTGGAAGACGACCTGACC
ATCATCGGCCGCGCGAAGGA

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTPAPATRNDPTMHTRGERWWEGPWPWLVYLIFYVLPWAWEPPHATDLIASAIGLAVFLPVYFVSHRLTDLPLLACAGIM
LGIGIALAPFGSWTVFPIYASAVAGHLRPVRFAVATVAAIAVATALAGLAWHQPVLWWFPGILLVIIIGGSTMSRVAFHE
RTQALLASQEEVRRLAGTAERERIARDLHDVIGRALTLTALKADLAARLAPRDAEAAEAEMRAVAALAREGLAEIRAALA
GHAGGSLAHEIAASTAALEAANIASTLAGDPAAIPADAGAVLAMTLREAVTNVIRHAEATCCVIQLDHHDGTARLSVCDN
GHGRSFTEGRGLTGMRQRLAAAGGALAFQPGTPEAGRQGIRLVATVPA

Sequences:

>Translated_368_residues
MTPAPATRNDPTMHTRGERWWEGPWPWLVYLIFYVLPWAWEPPHATDLIASAIGLAVFLPVYFVSHRLTDLPLLACAGIM
LGIGIALAPFGSWTVFPIYASAVAGHLRPVRFAVATVAAIAVATALAGLAWHQPVLWWFPGILLVIIIGGSTMSRVAFHE
RTQALLASQEEVRRLAGTAERERIARDLHDVIGRALTLTALKADLAARLAPRDAEAAEAEMRAVAALAREGLAEIRAALA
GHAGGSLAHEIAASTAALEAANIASTLAGDPAAIPADAGAVLAMTLREAVTNVIRHAEATCCVIQLDHHDGTARLSVCDN
GHGRSFTEGRGLTGMRQRLAAAGGALAFQPGTPEAGRQGIRLVATVPA
>Mature_367_residues
TPAPATRNDPTMHTRGERWWEGPWPWLVYLIFYVLPWAWEPPHATDLIASAIGLAVFLPVYFVSHRLTDLPLLACAGIML
GIGIALAPFGSWTVFPIYASAVAGHLRPVRFAVATVAAIAVATALAGLAWHQPVLWWFPGILLVIIIGGSTMSRVAFHER
TQALLASQEEVRRLAGTAERERIARDLHDVIGRALTLTALKADLAARLAPRDAEAAEAEMRAVAALAREGLAEIRAALAG
HAGGSLAHEIAASTAALEAANIASTLAGDPAAIPADAGAVLAMTLREAVTNVIRHAEATCCVIQLDHHDGTARLSVCDNG
HGRSFTEGRGLTGMRQRLAAAGGALAFQPGTPEAGRQGIRLVATVPA

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=215, Percent_Identity=26.9767441860465, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38813; Mature: 38682

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAPATRNDPTMHTRGERWWEGPWPWLVYLIFYVLPWAWEPPHATDLIASAIGLAVFLP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VYFVSHRLTDLPLLACAGIMLGIGIALAPFGSWTVFPIYASAVAGHLRPVRFAVATVAAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVATALAGLAWHQPVLWWFPGILLVIIIGGSTMSRVAFHERTQALLASQEEVRRLAGTAE
HHHHHHHHHHHCCHHHHHHHHHHEEHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
RERIARDLHDVIGRALTLTALKADLAARLAPRDAEAAEAEMRAVAALAREGLAEIRAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHAGGSLAHEIAASTAALEAANIASTLAGDPAAIPADAGAVLAMTLREAVTNVIRHAEAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
CCVIQLDHHDGTARLSVCDNGHGRSFTEGRGLTGMRQRLAAAGGALAFQPGTPEAGRQGI
EEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCE
RLVATVPA
EEEEECCC
>Mature Secondary Structure 
TPAPATRNDPTMHTRGERWWEGPWPWLVYLIFYVLPWAWEPPHATDLIASAIGLAVFLP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VYFVSHRLTDLPLLACAGIMLGIGIALAPFGSWTVFPIYASAVAGHLRPVRFAVATVAAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVATALAGLAWHQPVLWWFPGILLVIIIGGSTMSRVAFHERTQALLASQEEVRRLAGTAE
HHHHHHHHHHHCCHHHHHHHHHHEEHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCHH
RERIARDLHDVIGRALTLTALKADLAARLAPRDAEAAEAEMRAVAALAREGLAEIRAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHAGGSLAHEIAASTAALEAANIASTLAGDPAAIPADAGAVLAMTLREAVTNVIRHAEAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
CCVIQLDHHDGTARLSVCDNGHGRSFTEGRGLTGMRQRLAAAGGALAFQPGTPEAGRQGI
EEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCE
RLVATVPA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]