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The map label for this gene is proC [H]

Identifier: 162146747

GI number: 162146747

Start: 942174

End: 942995

Strand: Reverse

Name: proC [H]

Synonym: GDI_0925

Alternate gene names: 162146747

Gene position: 942995-942174 (Counterclockwise)

Preceding gene: 162146748

Following gene: 162146746

Centisome position: 23.91

GC content: 74.21

Gene sequence:

>822_bases
ATGACCCAGCCGGCCGGGCCTATTCCGCCCCTGCTGCTGGTGGGGTGCGGGCAGATGGGCAGTGCGATGCTGGCCGGCTG
GCTGGCCGACGGGCTGGCCCCGTCGGTCATCCTCGACCGGCATCGCGCCGACGGTCCGGCCCCGCATCGAATCGTCCGGC
AGGCGGCAGACCTGCCGGATGATTTCACCCCGGCGCTGATCGTCCTGGCCACCAAGCCGCAGAAGGCGGCTGCCGTGATC
CCGGACATCGCGCGGTTCGCCCGCCGCGCGCCGGTCCTGTCGGTCATGGCCGGCAAGACGGTCGGCGGCCTGGCGGCATC
CCTGGCCGATGCCGGGGCGCCCGGCGCCGTCGTCATTCGCGCCATGCCCAACACGCCGGCCGCCATCGGCCAGGGCATGA
CGGTCTGCTATGCCCCCCCCGCCGCGACCGAGGCCGAACGCGCGCTGTGCGGGCGGGTGCTGTCGGCGGTTGGCGATACC
GCCTGGGTCGAGCATGAGGAACAGATGGATGCCGTGACCGCGGTATCCGGCAGCGGCCCGGCCTATGTCTTCCTGCTGGC
CGAACTGATGGAACAGGCGGCCGTCGCCCAGGGCCTGCCGCCCGACCTGGCCCGGCGGATCGCCCGGCGCACGGTGTCGG
GTGCCGGCGCGCTGATGGAACAGTCGGGCGTGGATGCCGCCGAACTGCGCCGCCGCGTGACCAGCCCGGGCGGCACCACC
CAGCAGGCCCTGGCGGTCCTGATGGAGCCCGAGGCATGGCCCGCCGCGATGGACGCCGCCATCCGCGCCGCCACCCTGCG
CGCGCACGAACTCGCGTCCTGA

Upstream 100 bases:

>100_bases
AGTGCGAGCGGTTCTATCCCGCGTTCCAGTTCGTCCTGTGGGGCGGCAAGACGCCGGCCGAGGCGCTGGAAGCCGCCATG
CTGGACTGCGCGGGCGAGGC

Downstream 100 bases:

>100_bases
CGAACTTGCACACCGTCCCGACGTAATTTAACCGCAATACGGACCAAGCATGTCCGGATCGGCCGGACGACGCCACAGAC
CAGAAGACACGTCAGAAAAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTQPAGPIPPLLLVGCGQMGSAMLAGWLADGLAPSVILDRHRADGPAPHRIVRQAADLPDDFTPALIVLATKPQKAAAVI
PDIARFARRAPVLSVMAGKTVGGLAASLADAGAPGAVVIRAMPNTPAAIGQGMTVCYAPPAATEAERALCGRVLSAVGDT
AWVEHEEQMDAVTAVSGSGPAYVFLLAELMEQAAVAQGLPPDLARRIARRTVSGAGALMEQSGVDAAELRRRVTSPGGTT
QQALAVLMEPEAWPAAMDAAIRAATLRAHELAS

Sequences:

>Translated_273_residues
MTQPAGPIPPLLLVGCGQMGSAMLAGWLADGLAPSVILDRHRADGPAPHRIVRQAADLPDDFTPALIVLATKPQKAAAVI
PDIARFARRAPVLSVMAGKTVGGLAASLADAGAPGAVVIRAMPNTPAAIGQGMTVCYAPPAATEAERALCGRVLSAVGDT
AWVEHEEQMDAVTAVSGSGPAYVFLLAELMEQAAVAQGLPPDLARRIARRTVSGAGALMEQSGVDAAELRRRVTSPGGTT
QQALAVLMEPEAWPAAMDAAIRAATLRAHELAS
>Mature_272_residues
TQPAGPIPPLLLVGCGQMGSAMLAGWLADGLAPSVILDRHRADGPAPHRIVRQAADLPDDFTPALIVLATKPQKAAAVIP
DIARFARRAPVLSVMAGKTVGGLAASLADAGAPGAVVIRAMPNTPAAIGQGMTVCYAPPAATEAERALCGRVLSAVGDTA
WVEHEEQMDAVTAVSGSGPAYVFLLAELMEQAAVAQGLPPDLARRIARRTVSGAGALMEQSGVDAAELRRRVTSPGGTTQ
QALAVLMEPEAWPAAMDAAIRAATLRAHELAS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=32.8413284132841, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=32.8413284132841, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=30.4832713754647, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI198041662, Length=208, Percent_Identity=34.6153846153846, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786585, Length=273, Percent_Identity=31.1355311355311, Blast_Score=100, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17540664, Length=291, Percent_Identity=27.1477663230241, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=28.6245353159851, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=270, Percent_Identity=28.1481481481481, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=35.9550561797753, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24647700, Length=175, Percent_Identity=41.7142857142857, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24648116, Length=180, Percent_Identity=32.7777777777778, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27921; Mature: 27789

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPAGPIPPLLLVGCGQMGSAMLAGWLADGLAPSVILDRHRADGPAPHRIVRQAADLPD
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCC
DFTPALIVLATKPQKAAAVIPDIARFARRAPVLSVMAGKTVGGLAASLADAGAPGAVVIR
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEE
AMPNTPAAIGQGMTVCYAPPAATEAERALCGRVLSAVGDTAWVEHEEQMDAVTAVSGSGP
ECCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
AYVFLLAELMEQAAVAQGLPPDLARRIARRTVSGAGALMEQSGVDAAELRRRVTSPGGTT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCH
QQALAVLMEPEAWPAAMDAAIRAATLRAHELAS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQPAGPIPPLLLVGCGQMGSAMLAGWLADGLAPSVILDRHRADGPAPHRIVRQAADLPD
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCC
DFTPALIVLATKPQKAAAVIPDIARFARRAPVLSVMAGKTVGGLAASLADAGAPGAVVIR
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEE
AMPNTPAAIGQGMTVCYAPPAATEAERALCGRVLSAVGDTAWVEHEEQMDAVTAVSGSGP
ECCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
AYVFLLAELMEQAAVAQGLPPDLARRIARRTVSGAGALMEQSGVDAAELRRRVTSPGGTT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCH
QQALAVLMEPEAWPAAMDAAIRAATLRAHELAS
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]