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The map label for this gene is trpC [H]

Identifier: 161986624

GI number: 161986624

Start: 950382

End: 951191

Strand: Direct

Name: trpC [H]

Synonym: jk0797

Alternate gene names: 161986624

Gene position: 950382-951191 (Clockwise)

Preceding gene: 68535871

Following gene: 68535873

Centisome position: 38.59

GC content: 65.31

Gene sequence:

>810_bases
ATGACTGTTCTCGACCAGATCATTGCCGGGGTGCTAGACGACCAGGCCGAGCGGGAAGCCAAGATCCCATACAAGGAGAT
CAAGGCCATGTCCCTGGACGCACCACCGGCTCTCGACGCCCACGCCGCGCTGGCCGCCCCCGGGGTCAGCCTCATTGCCG
AGGTGAAGCGCGCCAGCCCCTCCAAGGGGGACCTCGCCGAGATCGCCGATCCCGAAGTGCTGGCGAAGGCCTACGAGGAC
AATGGGGCCACCGCCATCAGCTGCCTCACCGAACAGCGCCGCTTCAAGGGCTCCCTCGAGGACTTCGACGCGGTGCGCCG
GGCGGTGAACATTCCGCTGCTGCGCAAGGACTTCACGGTGAACCCGTACCAGATCCACGAGGCCCGGGCGCACGGCGCGG
ACATCGTGCTGCTCATCGTCGCTGCACTCGAACAGCAGCGCCTGGAATCCTTGCTGGATCGAACCGAGTCCCTGGGTATG
ACCGCCCTGGTGGAAGTGCACACCGCCGAAGAAGCCGAGCGCGCTGTTGCCGCCGGTGCCAAGGTCATTGGGGTCAATGC
CCGAAACCTCAAGACGCTGGACGTCGACCCGCAGGTGTTCAGCAAGATTGCCCCGCTGCTTCCGGACGACGTGGTGAAGA
TCGCAGAGTCGGGCGTCAAGAATAAAAACGACCTCAACGCCTATGCCGCAGCGGGCGCGGACGCAGTGCTCGTCGGCGAA
GGCCTGGTCACCGCAGGTAACCCCGCCCAGGCGTGCCGGGACCTCGCCGCAGCGGGAAAACACCCAGCCTGCCCCCAAAA
GAATTCCTAA

Upstream 100 bases:

>100_bases
CGCGTGCTGTGGGATGCCCTGGATGCGGGGGTGGATCCGACCGAAGAATCCGATTTCTCCCGCACCAAGCAGGGGCGATA
AGCTCAGGGGTGTGACACAC

Downstream 100 bases:

>100_bases
GCGATAGCATATAAAACTGTGACTACCGAGAAGACCTTCAAGAACGCCGACGCGCAAGGCAAGACCCTGCCGACGGTAGG
CGAGATCCTGGCGACCGCCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTVLDQIIAGVLDDQAEREAKIPYKEIKAMSLDAPPALDAHAALAAPGVSLIAEVKRASPSKGDLAEIADPEVLAKAYED
NGATAISCLTEQRRFKGSLEDFDAVRRAVNIPLLRKDFTVNPYQIHEARAHGADIVLLIVAALEQQRLESLLDRTESLGM
TALVEVHTAEEAERAVAAGAKVIGVNARNLKTLDVDPQVFSKIAPLLPDDVVKIAESGVKNKNDLNAYAAAGADAVLVGE
GLVTAGNPAQACRDLAAAGKHPACPQKNS

Sequences:

>Translated_269_residues
MTVLDQIIAGVLDDQAEREAKIPYKEIKAMSLDAPPALDAHAALAAPGVSLIAEVKRASPSKGDLAEIADPEVLAKAYED
NGATAISCLTEQRRFKGSLEDFDAVRRAVNIPLLRKDFTVNPYQIHEARAHGADIVLLIVAALEQQRLESLLDRTESLGM
TALVEVHTAEEAERAVAAGAKVIGVNARNLKTLDVDPQVFSKIAPLLPDDVVKIAESGVKNKNDLNAYAAAGADAVLVGE
GLVTAGNPAQACRDLAAAGKHPACPQKNS
>Mature_268_residues
TVLDQIIAGVLDDQAEREAKIPYKEIKAMSLDAPPALDAHAALAAPGVSLIAEVKRASPSKGDLAEIADPEVLAKAYEDN
GATAISCLTEQRRFKGSLEDFDAVRRAVNIPLLRKDFTVNPYQIHEARAHGADIVLLIVAALEQQRLESLLDRTESLGMT
ALVEVHTAEEAERAVAAGAKVIGVNARNLKTLDVDPQVFSKIAPLLPDDVVKIAESGVKNKNDLNAYAAAGADAVLVGEG
LVTAGNPAQACRDLAAAGKHPACPQKNS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=214, Percent_Identity=37.3831775700935, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=38.1481481481481, Blast_Score=155, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28378; Mature: 28246

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLDQIIAGVLDDQAEREAKIPYKEIKAMSLDAPPALDAHAALAAPGVSLIAEVKRASP
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHCCC
SKGDLAEIADPEVLAKAYEDNGATAISCLTEQRRFKGSLEDFDAVRRAVNIPLLRKDFTV
CCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCC
NPYQIHEARAHGADIVLLIVAALEQQRLESLLDRTESLGMTALVEVHTAEEAERAVAAGA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCC
KVIGVNARNLKTLDVDPQVFSKIAPLLPDDVVKIAESGVKNKNDLNAYAAAGADAVLVGE
EEEECCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECC
GLVTAGNPAQACRDLAAAGKHPACPQKNS
CCEECCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TVLDQIIAGVLDDQAEREAKIPYKEIKAMSLDAPPALDAHAALAAPGVSLIAEVKRASP
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHCCC
SKGDLAEIADPEVLAKAYEDNGATAISCLTEQRRFKGSLEDFDAVRRAVNIPLLRKDFTV
CCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCC
NPYQIHEARAHGADIVLLIVAALEQQRLESLLDRTESLGMTALVEVHTAEEAERAVAAGA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCC
KVIGVNARNLKTLDVDPQVFSKIAPLLPDDVVKIAESGVKNKNDLNAYAAAGADAVLVGE
EEEECCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECC
GLVTAGNPAQACRDLAAAGKHPACPQKNS
CCEECCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA