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The map label for this gene is lpxB [H]

Identifier: 161871036

GI number: 161871036

Start: 1999390

End: 2000367

Strand: Reverse

Name: lpxB [H]

Synonym: NMCC_1949

Alternate gene names: 161871036

Gene position: 2000367-1999390 (Counterclockwise)

Preceding gene: 161870862

Following gene: 161870861

Centisome position: 92.89

GC content: 58.08

Gene sequence:

>978_bases
CTGGCGGTGCGCGGCTTTGTCGAAGTGGTCAGGCGGCTGCCGGAAATTTTACGGATACGCAGGGGGCTGGTACGGGATTT
GCTGTCGTTGAAACCTGATGTCTTTGTCGGTATCGATGCGCCCGATTTTAATTTGGGTGTGGCGGAAAAGCTGAAACGGT
CGGGGATTCCGACCGTGCATTATGTCAGCCCGTCGGTGTGGGCGTGGCGGCGGGAACGTGTGGGCAAAATCGTGCATCAG
GTCAACCGCGTGTTGTGCCTGTTCCCGATGGAGCCGCAGCTTTATCTCGATGCGGGCGGACGTGCGGAGTTTGTCGGTCA
TCCGATGGCGCAGCTTATGCCCTTGGAAGACGACCGTGAAACGGCGCGGCAAACTTTGGGCGTGGATGCCGGCATCCCCG
TATTCGCCCTGCTGCCCGGCAGCCGCGTCAGCGAAATCGACTATATGGCGCCGGTGTTTTTTCAGACGGCATTATTGTTG
TTGGAACGCTATCCTGCCGCATGCTTCCTGCTGCCTGCCGCAACGGAGGCGACGAAGCGGCGTTTGGCGGAAGTTTTGCA
GCGGCCGGAGTTTGCCGGATTGCCGCTGACGGTAATCGACAGACAGTCTGAAACAGTGTGCAGGGCGGCGGATGCGGTGC
TGGTAACGAGCGGTACGGCGACTTTGGAGGTGGCGTTGTGCAAGCGTCCGATGGTCATCAGCTACAAGATTTCGCCGCTG
ACTTATGCTTATGTGAAACGCAAAATCAAAGTGCCGCATGTCGGCCTGCCGAATATCCTGTTGGGTAAGGAGGCTGTGCC
GGAATTATTGCAATCTGAAGCAAAACCGGAAAAACTGGCGGCGGCGTTGGCGGACTGGTACGAACACCCCGATAAGGTTG
CCGCGCTGCAACAGGATTTCAGGGCGTTGCACCTGCTGTTGAAAAAAGATACGGCGGATTTGGCCGCGCGCGCGGTTTTG
GAAGAGGCGGGATGTTGA

Upstream 100 bases:

>100_bases
ACGCGCCATCCGCAAGCGTTGTCCGCAGGCGCGTTTTGTCGGTATCGGCGGCGAACTGATGAAGGCGGAAGGTTTCGAGA
GCCTTTATGATCAGGAGCGG

Downstream 100 bases:

>100_bases
GCGGTTAATGGATTATTTTCCCGAAGCAGCACGTATTACAAAAAAAGGGGGAGAAATTGTGATTAATGGCACATCAAACA
ATAAGTATTTAAGAGGAATT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVHYVSPSVWAWRRERVGKIVHQ
VNRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRETARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLL
LERYPAACFLLPAATEATKRRLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPL
TYAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDFRALHLLLKKDTADLAARAVL
EEAGC

Sequences:

>Translated_325_residues
MAVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVHYVSPSVWAWRRERVGKIVHQ
VNRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRETARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLL
LERYPAACFLLPAATEATKRRLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPL
TYAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDFRALHLLLKKDTADLAARAVL
EEAGC
>Mature_324_residues
AVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVHYVSPSVWAWRRERVGKIVHQV
NRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRETARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLLL
ERYPAACFLLPAATEATKRRLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPLT
YAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDFRALHLLLKKDTADLAARAVLE
EAGC

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=323, Percent_Identity=43.0340557275542, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 36014; Mature: 35883

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCEEE
YVSPSVWAWRRERVGKIVHQVNRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRE
ECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCCHHCCCCHHHHCCCCCHHH
TARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLLLERYPAACFLLPAATEATKR
HHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
RLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPL
HHHHHHHCCCCCCCCEEEECCCCHHHHHHHCEEEEECCCCEEEEEECCCCEEEEEEECCH
TYAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDF
HHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
RALHLLLKKDTADLAARAVLEEAGC
HHHHHHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVRGFVEVVRRLPEILRIRRGLVRDLLSLKPDVFVGIDAPDFNLGVAEKLKRSGIPTVH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCEEE
YVSPSVWAWRRERVGKIVHQVNRVLCLFPMEPQLYLDAGGRAEFVGHPMAQLMPLEDDRE
ECCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCCHHCCCCHHHHCCCCCHHH
TARQTLGVDAGIPVFALLPGSRVSEIDYMAPVFFQTALLLLERYPAACFLLPAATEATKR
HHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
RLAEVLQRPEFAGLPLTVIDRQSETVCRAADAVLVTSGTATLEVALCKRPMVISYKISPL
HHHHHHHCCCCCCCCEEEECCCCHHHHHHHCEEEEECCCCEEEEEECCCCEEEEEEECCH
TYAYVKRKIKVPHVGLPNILLGKEAVPELLQSEAKPEKLAAALADWYEHPDKVAALQQDF
HHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
RALHLLLKKDTADLAARAVLEEAGC
HHHHHHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA