Click here to switch to the map view.

The map label for this gene is argG [H]

Identifier: 161870992

GI number: 161870992

Start: 2116223

End: 2117566

Strand: Direct

Name: argG [H]

Synonym: NMCC_2087

Alternate gene names: 161870992

Gene position: 2116223-2117566 (Clockwise)

Preceding gene: 161870988

Following gene: 161870993

Centisome position: 98.27

GC content: 56.25

Gene sequence:

>1344_bases
ATGAGCCAAAACCATACCATTCTGCAATCCCTCCCCGTCGGTCAGAAAGTCGGCATCGCCTTCTCCGGCGGACTTGATAC
CTCCGCCGCGCTGTTGTGGATGAAACTCAAAGGCGCGCTGCCTTATGCCTACACTGCCAACCTCGGCCAGCCCGACGAAG
ACGATTACAACGCCATTCCTAAAAAAGCAATGGAATACGGTGCGGAAAACGCCCGCCTGATCGACTGCCGCGCGCAGTTG
GCACACGAAGGCATCGCCGCCATCCAATGCGGCGCGTTCCACGTTTCCACCGGCGGCATCGCCTATTTCAACACCACGCC
TCTGGGTCGCGCCGTAACCGGCACGATGCTTGTTTCCGCCATGAAAGAAGACGATGTGAATATTTGGGGCGACGGCAGCA
CCTACAAAGGCAACGACATCGAGCGTTTCTACCGCTACGGTTTGCTCACCAATCCCGCGCTGAAAATCTACAAACCCTGG
CTCGATCAGCAATTTATCGACGAACTCGGCGGCCGTCACGAAATGAGCGAATTTCTGATTGCCAACGGCTTCAACTACAA
AATGTCGGTGGAAAAAGCCTACTCCACCGATTCCAATATGTTGGGTGCCACCCACGAAGCCAAAGACTTGGAATTTTTGA
ACTCGGGCATCAAAATCGTCAAACCCATTATGGGCGTTGCCTTTTGGGACGAAAACGTCGAAGTCAGCCCCGAAGAAGTC
AGCGTGCGCTTTGAAGAAGGCGTGCCGGTTGCACTGAACGGCAAAGAATACGCCGATCCCGTCGAACTCTTCCTCGAAGC
CAACCGCATCGGCGGCCGCCACGGCTTGGGCATGAGCGACCAAATCGAAAACCGCATCATCGAAGCCAAATCGCGCGGCA
TCTACGAAGCCCCGGGCATGGCATTGTTCCACATCGCCTACGAACGCTTGGTTACCGGCATCCACAACGAGGACACCATC
GAACAATACCGCATCAACGGCCTGCGCCTCGGCCGCCTGCTCTACCAAGGCCGCTGGTTCGACAGCCAAGCACTCATGTT
GCGCGAAACCGCCCAACGCTGGGTCGCCAAAGCCATTACCGGCGAAGTAACCCTCGAATTGCGTCGCGGCAACGACTACT
CGATTCTGAACACCGAATCGCCCAACCTGACCTACCAACCCGAACGCCTGAGTATGGAAAAAGTCGAAGACGCAGCGTTC
ACACCGCTCGACCGTATCGGACAACTGACTATGCGCAACCTCGACATCACCGACACCCGCGCCAAACTGGGCATCTACTC
GCAAAGCGGTTTGCTCTCGCTGGGCGAAGGTTCGGTATTGCCGCAGTTGGGCAATAAGCAATAA

Upstream 100 bases:

>100_bases
CGAAACGGGCAAAGCTTCTTTTCAGACAGCCTTAACGGCTGACAATGGGTTATATTTATAAGATAATGAACTCCTTTTTT
CAAGTCCGAAGGATACCCTT

Downstream 100 bases:

>100_bases
GGTTTGCTGTTTTACATCATTAGCAACTTAAGGGGTCGTCTGAAAAGATGATCCCTTATGTTAAAAGGAATCCTATGAAA
GAATACAAAGTCGTCATTTA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSQNHTILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIPKKAMEYGAENARLIDCRAQL
AHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDDVNIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPW
LDQQFIDELGGRHEMSEFLIANGFNYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEV
SVRFEEGVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIAYERLVTGIHNEDTI
EQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAKAITGEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAF
TPLDRIGQLTMRNLDITDTRAKLGIYSQSGLLSLGEGSVLPQLGNKQ

Sequences:

>Translated_447_residues
MSQNHTILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIPKKAMEYGAENARLIDCRAQL
AHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDDVNIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPW
LDQQFIDELGGRHEMSEFLIANGFNYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEV
SVRFEEGVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIAYERLVTGIHNEDTI
EQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAKAITGEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAF
TPLDRIGQLTMRNLDITDTRAKLGIYSQSGLLSLGEGSVLPQLGNKQ
>Mature_446_residues
SQNHTILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIPKKAMEYGAENARLIDCRAQLA
HEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDDVNIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPWL
DQQFIDELGGRHEMSEFLIANGFNYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEVS
VRFEEGVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIAYERLVTGIHNEDTIE
QYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAKAITGEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAFT
PLDRIGQLTMRNLDITDTRAKLGIYSQSGLLSLGEGSVLPQLGNKQ

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=408, Percent_Identity=28.6764705882353, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI16950633, Length=408, Percent_Identity=28.6764705882353, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1789563, Length=440, Percent_Identity=81.1363636363636, Blast_Score=747, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324514, Length=418, Percent_Identity=27.511961722488, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21358151, Length=425, Percent_Identity=26.5882352941176, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 49651; Mature: 49520

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNHTILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIP
CCCCCCCHHHCCCCCEECEEEECCCCHHHHEEEEEHHCCCCEEEECCCCCCCCCCHHHCC
KKAMEYGAENARLIDCRAQLAHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSA
HHHHHCCCCCCEEEHHHHHHHHCCCEEEEECEEEEECCCEEEEECCCCCHHHHHHHHHHH
MKEDDVNIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPWLDQQFIDELGGRHEMSEFLI
HHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCHHHHHHHHH
ANGFNYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEV
CCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHEEEECCCCCCCHHHE
SVRFEEGVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGM
EEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCH
ALFHIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAKAIT
HHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAFTPLDRIGQLTMRNLDITDTR
CEEEEEEECCCCEEEEECCCCCCEECHHHCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
AKLGIYSQSGLLSLGEGSVLPQLGNKQ
HHEEEECCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SQNHTILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIP
CCCCCCHHHCCCCCEECEEEECCCCHHHHEEEEEHHCCCCEEEECCCCCCCCCCHHHCC
KKAMEYGAENARLIDCRAQLAHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSA
HHHHHCCCCCCEEEHHHHHHHHCCCEEEEECEEEEECCCEEEEECCCCCHHHHHHHHHHH
MKEDDVNIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPWLDQQFIDELGGRHEMSEFLI
HHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCHHHHHHHHH
ANGFNYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEV
CCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHEEEECCCCCCCHHHE
SVRFEEGVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGM
EEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCH
ALFHIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAKAIT
HHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAFTPLDRIGQLTMRNLDITDTR
CEEEEEEECCCCEEEEECCCCCCEECHHHCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
AKLGIYSQSGLLSLGEGSVLPQLGNKQ
HHEEEECCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA