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The map label for this gene is map [H]

Identifier: 161870963

GI number: 161870963

Start: 2095967

End: 2096746

Strand: Direct

Name: map [H]

Synonym: NMCC_2058

Alternate gene names: 161870963

Gene position: 2095967-2096746 (Clockwise)

Preceding gene: 161870962

Following gene: 161870964

Centisome position: 97.33

GC content: 57.56

Gene sequence:

>780_bases
ATGAACGGCATCATCATCAAAACCCCCGAAGAAATCGAAAAAATGCGCGAGCTGGGCAAACTCGTCGCCGAAGCCCTCGA
CTACATCGGACAATTCGTCAAACCCGGCGTAACCACCGACGAAATCGACAAACTCGTTTACGACTACCACGTCAACGTCC
AAGGCGGCTATCCCGCCCCCCTGCACTACGGCAACCCGCCCTACCCCAAATCCTGCTGCACCTCCGTCAACCACGTCATC
TGCCACGGCATTCCCGACGACAAGCCGCTCAAAGAAGGCGACATTATCAACATCGACCTCACCATCAAAAAAGACGGCTT
CCACGGCGACTCCAGCCGTATGTTTACCGTCGGCAAAGTCTCCCCCATCGCCCAACGCCTGATCGACGTAACCCACGCCT
CCATGATGGCGGGCATAGAAGCCGTCAAACCCGGCGCGACACTGGGCGACGTAGGTTACGCCTGCCAACAGGTTGCCGAA
AACGCCGGCTATTCCGTCGTACAGGAATTCTGCGGACACGGCATCGGGCGCGGTTTCCACGAAGCCCCGCAAGTGTTGCA
CTACGGAAAAAAAGGACAGGGCCCCGTTCTAAAACCGGGTATGATTTTTACCGTCGAACCGATGATCAACCAAGGCAAAC
GCCACCTGCGTATCCTCAACGACGGCTGGACGGTGGTTACCAAAGACCGCTCCCTCTCCGCCCAATGGGAACACGAAGTC
TTGGTGACCGAAACCGGCTACGAAATCCTCACCGTCAGCCCCGCCTCCGGCAAACCCTGA

Upstream 100 bases:

>100_bases
GGACACCCCGAAAAACACGCCGCCCAAACCCCATAAAGAAATTCTCGACAACCTCTTCTGACCCGGCACGGCAGGCACAC
CCGCAATCCAAGGAAGCATT

Downstream 100 bases:

>100_bases
AACCGGACGTATCCGCCCCATAAAAACAAACAATGCCGTCTGAAAGAAACGGCAGATATGATATATAATATAAAAACAGG
CTTGACCCGGCACATTACGA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNGIIIKTPEEIEKMRELGKLVAEALDYIGQFVKPGVTTDEIDKLVYDYHVNVQGGYPAPLHYGNPPYPKSCCTSVNHVI
CHGIPDDKPLKEGDIINIDLTIKKDGFHGDSSRMFTVGKVSPIAQRLIDVTHASMMAGIEAVKPGATLGDVGYACQQVAE
NAGYSVVQEFCGHGIGRGFHEAPQVLHYGKKGQGPVLKPGMIFTVEPMINQGKRHLRILNDGWTVVTKDRSLSAQWEHEV
LVTETGYEILTVSPASGKP

Sequences:

>Translated_259_residues
MNGIIIKTPEEIEKMRELGKLVAEALDYIGQFVKPGVTTDEIDKLVYDYHVNVQGGYPAPLHYGNPPYPKSCCTSVNHVI
CHGIPDDKPLKEGDIINIDLTIKKDGFHGDSSRMFTVGKVSPIAQRLIDVTHASMMAGIEAVKPGATLGDVGYACQQVAE
NAGYSVVQEFCGHGIGRGFHEAPQVLHYGKKGQGPVLKPGMIFTVEPMINQGKRHLRILNDGWTVVTKDRSLSAQWEHEV
LVTETGYEILTVSPASGKP
>Mature_259_residues
MNGIIIKTPEEIEKMRELGKLVAEALDYIGQFVKPGVTTDEIDKLVYDYHVNVQGGYPAPLHYGNPPYPKSCCTSVNHVI
CHGIPDDKPLKEGDIINIDLTIKKDGFHGDSSRMFTVGKVSPIAQRLIDVTHASMMAGIEAVKPGATLGDVGYACQQVAE
NAGYSVVQEFCGHGIGRGFHEAPQVLHYGKKGQGPVLKPGMIFTVEPMINQGKRHLRILNDGWTVVTKDRSLSAQWEHEV
LVTETGYEILTVSPASGKP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=48.046875, Blast_Score=244, Evalue=5e-65,
Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=40.3162055335968, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI1786364, Length=258, Percent_Identity=56.2015503875969, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI1788728, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789275, Length=270, Percent_Identity=25.1851851851852, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=46.5863453815261, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=43.4782608695652, Blast_Score=215, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21355531, Length=242, Percent_Identity=49.5867768595041, Blast_Score=233, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=40.650406504065, Blast_Score=201, Evalue=5e-52,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28247; Mature: 28247

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGIIIKTPEEIEKMRELGKLVAEALDYIGQFVKPGVTTDEIDKLVYDYHVNVQGGYPAP
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEEEECCCCCCC
LHYGNPPYPKSCCTSVNHVICHGIPDDKPLKEGDIINIDLTIKKDGFHGDSSRMFTVGKV
CCCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCC
SPIAQRLIDVTHASMMAGIEAVKPGATLGDVGYACQQVAENAGYSVVQEFCGHGIGRGFH
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHH
EAPQVLHYGKKGQGPVLKPGMIFTVEPMINQGKRHLRILNDGWTVVTKDRSLSAQWEHEV
HHHHHHHCCCCCCCCCCCCCEEEEECHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCEE
LVTETGYEILTVSPASGKP
EEEECCCEEEEECCCCCCC
>Mature Secondary Structure
MNGIIIKTPEEIEKMRELGKLVAEALDYIGQFVKPGVTTDEIDKLVYDYHVNVQGGYPAP
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEEEEECCCCCCC
LHYGNPPYPKSCCTSVNHVICHGIPDDKPLKEGDIINIDLTIKKDGFHGDSSRMFTVGKV
CCCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCC
SPIAQRLIDVTHASMMAGIEAVKPGATLGDVGYACQQVAENAGYSVVQEFCGHGIGRGFH
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHH
EAPQVLHYGKKGQGPVLKPGMIFTVEPMINQGKRHLRILNDGWTVVTKDRSLSAQWEHEV
HHHHHHHCCCCCCCCCCCCCEEEEECHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCEE
LVTETGYEILTVSPASGKP
EEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]