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The map label for this gene is zupT

Identifier: 161870888

GI number: 161870888

Start: 2029880

End: 2030599

Strand: Direct

Name: zupT

Synonym: NMCC_1977

Alternate gene names: 161870888

Gene position: 2029880-2030599 (Clockwise)

Preceding gene: 161870887

Following gene: 161870889

Centisome position: 94.26

GC content: 55.0

Gene sequence:

>720_bases
ATGTTTTCCAAAACGCCCAATCCGCGCGTGTTGTCGTTTGGTTTGGCATTTGCCGGCGGTGCGATGGTGTATGTTTCCCT
GACGGAGATTTTCAGTAAGTCCAGCGAGGCGTTCGCTGAAATTTATGATAAAGACCACGCGTTTGCGGCGGCGACCATGG
CATTTTTGGCAGGGATGGGCGGCATTGCGCTGATTGACCGTCTGGTGCCGAACCCGCATGAAACTTTAGACGCGCAAGAC
CCGTCGTTTCAAGAAAGCAAACGCCGCCATATCGCGCGAGTCGGCATGATGGCGGCGTTTGCGATTACTGCGCACAATTT
CCCCGAAGGCTTGGCGACGTTTTTTGCCACATTGGAAAATCCAGCAGTCGGGATGCCTTTGGCCTTGGCGATTGCCATCC
ATAATATTCCGGAGGGCATTTCCATCGCCGCGCCGGTTTATTTTGCCACCCGCAGCCGTAAGAAAACGGTGTGGGCGTGT
CTGCTATCCGGCTTGGCCGAGCCGTTGGGGGCGGCTTTGGGCTATTTGGTTTTGCAGCCGTTTTTGTCGCCTGCCGTGTT
TGGTTCGGTATTCGGCGTGATAGCCGGTGTGATGGTGTTTTTGGCGTTGGACGAGCTGCTGCCGGCTGCCAAACGCTATT
CAGACGGCCATGAAACCGTTTACGGCCTGACAATGGGCATGGCGGTGATTGCCGTCAGCCTGGTATTGTTCCATTTTTAA

Upstream 100 bases:

>100_bases
AGGTTTTCTCATGCCCGATTTTTCGATGTCCAATTTGGCCGTTGCCTTTTCCATTACGTTGGCTGCCGGTTTGTTTACCG
TATTAGGCAGCGGCTTGGTG

Downstream 100 bases:

>100_bases
AACCTGTATGCCAAAGGCCGTCTGAAATGATTCAGACGGCCTTTTTGCGTTATAATCCGCACATCAAAAATAACCTTAAT
TTCACAAAGTTCCATCATGT

Product: zinc transporter ZupT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQD
PSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWAC
LLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF

Sequences:

>Translated_239_residues
MFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQD
PSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWAC
LLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF
>Mature_239_residues
MFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQD
PSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWAC
LLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF

Specific function: Mediates zinc uptake. May also transport other divalent cations

COG id: COG0428

COG function: function code P; Predicted divalent heavy-metal cations transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily

Homologues:

Organism=Homo sapiens, GI229577418, Length=169, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI229577422, Length=169, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1789419, Length=240, Percent_Identity=36.25, Blast_Score=143, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17507805, Length=287, Percent_Identity=25.0871080139373, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24652846, Length=170, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZUPT_NEIMA (Q9JX23)

Other databases:

- EMBL:   AL157959
- PIR:   D82001
- RefSeq:   YP_002341645.1
- EnsemblBacteria:   EBNEIT00000001390
- GeneID:   906108
- GenomeReviews:   AL157959_GR
- KEGG:   nma:NMA0093
- GeneTree:   EBGT00050000021947
- HOGENOM:   HBG620552
- OMA:   VSVPIYY
- ProtClustDB:   PRK04201
- BioCyc:   NMEN122587:NMA0093-MONOMER
- HAMAP:   MF_00548
- InterPro:   IPR003689

Pfam domain/function: PF02535 Zip

EC number: NA

Molecular weight: Translated: 25443; Mature: 25443

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x161e0d5c)-; HASH(0x17d1b6f8)-; HASH(0x180cdebc)-; HASH(0x1850020c)-; HASH(0x184f01ac)-; HASH(0x18197630)-; HASH(0x18303508)-; HASH(0x185166dc)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMG
CCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GIALIDRLVPNPHETLDAQDPSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLEN
HHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWACLLSGLAEPLGAALGYLVLQP
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMG
CCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GIALIDRLVPNPHETLDAQDPSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLEN
HHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
PAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWACLLSGLAEPLGAALGYLVLQP
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919