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The map label for this gene is lpxA [H]

Identifier: 161870885

GI number: 161870885

Start: 2025750

End: 2026526

Strand: Direct

Name: lpxA [H]

Synonym: NMCC_1974

Alternate gene names: 161870885

Gene position: 2025750-2026526 (Clockwise)

Preceding gene: 161870884

Following gene: 161870886

Centisome position: 94.07

GC content: 59.07

Gene sequence:

>777_bases
ATGACCCTCATCCACCCGACCGCCGTCATCGACCCCAAAGCCGAACTCGACTCCAGCGTCAAAGTCGGCGCGTACACCGT
CATCGGCCCCAACGTCCAAATCGGCGCGAATACCGAAATCGGCCCGCACGCCGTCATCAACGGCCACACCAGCATCGGCG
AAAACAACCGCATTTTCCAATTTGCCAGCCTCGGCGAAATTCCGCAGGACAAAAAATACCGCGACGAGCCGACCCGGCTG
ATTATCGGCAACGGCAACACCATCCGCGAATTTACGACGTTCAATCTCGGAACAGTTACTGGCATCGGCGAAACCCGTAT
CGGCGACGACAACTGGATTATGGCGTACTGCCACCTCGCGCACGACTGCGTGGTCGGCAACCACACCATTTTCGCCAACA
ACGCCTCGCTTGCCGGACACGTTACCATCGGCGACTACGTCGTTTTGGGCGGCTACACGCTGGTTTTCCAATTCTGCCGC
ATCGGCGACTACGCCATGACCGCCTTCGCCGCAGGCGTACACAAAGACGTACCGCCCTACTTTATGGCATCGGGCTACCG
CGCCGAACCGGCGGGGCTCAACAGCGAAGGCATGCGCCGCAACGGTTTTACCGCAGAGCAGATTTCCGCCGTCAAAGACG
TGTACAAAACCCTCTACCATCGCGGCATTCCGTTTGAAGAAGCCAAGGCAGACATTCTCCGCCGCGCCGAAACCCAAGCC
GAGCTTGCCGTATTCCGAGACTTTTTCGCACAATCGGCGCGCGGCATCATCCGCTGA

Upstream 100 bases:

>100_bases
AACGCGTGGTTTGAGTGTTCAGAAAAAGGTCGTCTGAAAGTTTTCAGACGACCTGTTGCCGTCGCGCATCTTCGCGGCAA
CACGACAGGAAAGGAAAAAC

Downstream 100 bases:

>100_bases
CCGTACCCTTTTGATGCCGTCTGAAACCCCGAAAGCGTTTCAGACGGCATCGGTTTTTTTAAAGCGGTATATTGTTTGAT
CGATGCATCATTTTGTAGAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQFASLGEIPQDKKYRDEPTRL
IIGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLAHDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCR
IGDYAMTAFAAGVHKDVPPYFMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRRAETQA
ELAVFRDFFAQSARGIIR

Sequences:

>Translated_258_residues
MTLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQFASLGEIPQDKKYRDEPTRL
IIGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLAHDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCR
IGDYAMTAFAAGVHKDVPPYFMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRRAETQA
ELAVFRDFFAQSARGIIR
>Mature_257_residues
TLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQFASLGEIPQDKKYRDEPTRLI
IGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLAHDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCRI
GDYAMTAFAAGVHKDVPPYFMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRRAETQAE
LAVFRDFFAQSARGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=48.4375, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1786376, Length=213, Percent_Identity=26.2910798122066, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28199; Mature: 28068

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQ
CEEECCCEEECCHHHCCCCEEEEEEEEECCCEEECCCCCCCCCEEECCCCCCCCCCCEEE
FASLGEIPQDKKYRDEPTRLIIGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLA
EECCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCEEEECCCCCEECCCCEEEEEEEHH
HDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCRIGDYAMTAFAAGVHKDVPPY
HHEEECCEEEEECCCCEEEEEEECCEEEECHHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
FMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRRAETQA
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ELAVFRDFFAQSARGIIR
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLIHPTAVIDPKAELDSSVKVGAYTVIGPNVQIGANTEIGPHAVINGHTSIGENNRIFQ
EEECCCEEECCHHHCCCCEEEEEEEEECCCEEECCCCCCCCCEEECCCCCCCCCCCEEE
FASLGEIPQDKKYRDEPTRLIIGNGNTIREFTTFNLGTVTGIGETRIGDDNWIMAYCHLA
EECCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCEEEECCCCCEECCCCEEEEEEEHH
HDCVVGNHTIFANNASLAGHVTIGDYVVLGGYTLVFQFCRIGDYAMTAFAAGVHKDVPPY
HHEEECCEEEEECCCCEEEEEEECCEEEECHHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
FMASGYRAEPAGLNSEGMRRNGFTAEQISAVKDVYKTLYHRGIPFEEAKADILRRAETQA
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ELAVFRDFFAQSARGIIR
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA