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The map label for this gene is dxr [H]

Identifier: 161870879

GI number: 161870879

Start: 2018477

End: 2019712

Strand: Direct

Name: dxr [H]

Synonym: NMCC_1968

Alternate gene names: 161870879

Gene position: 2018477-2019712 (Clockwise)

Preceding gene: 161870878

Following gene: 161870880

Centisome position: 93.73

GC content: 58.66

Gene sequence:

>1236_bases
ATGCCGTCTGAAAACGCTTCAGACGGCATCCGGTATAAAGTTATCCCCATTATGACACCACAAGTCCTGACCATATTAGG
CAGTACCGGCAGCATAGGCGAAAGCACGCTGGACGTTGTCTCCCTCCACCCCGAAAAATTCCGCGTATTCGCGCTGGCAG
GGCATAAGCAGGTCGAGAAACTGGCGGTGCAATGCCGGACGTTCCGCCCCGAATATGCCGTCGTTGCCGATGCCGAACAC
GCCGCCCGGCTTGAAGCTTTGTTGAAAGGCGACGGCACGGCGACGCAGGTTTTACACGGCGCGCAGGCATTGGTTGACGT
TGCCTCTGCCGACGAAGTCAGCGGTGTCATGTGCGCCATCGTCGGGGCGGTGGGGCTGCCTTCCGCGCTCGCAGCGGCGC
AAAAAGGCAAAACCATTTATCTGGCGAACAAAGAGACGCTGGTGGTTTCCGGCGCGTTGTTTATGGAAACCGCCCGTGCA
AACGGCGCGGCAGTGCTGCCCGTCGACAGCGAACACAACGCCGTTTTCCAAGTTTTGCCGCGCGATTACGCCGGCCGTCT
GAACGAACACGGCATCGCTTCGATTATCCTGACCGCTTCCGGCGGCCCGTTTCTGACCGCCGATTTAAACACGTTCGACA
GCATTACGCCCGACCAAGCGGTCAAACACCCCAATTGGCGTATGGGACGCAAAATCTCCGTCGATTCCGCCACCATGATG
AACAAAGGTTTGGAGCTGATTGAAGCGCATTGGCTGTTCAACTGTCCGCCCGACAAACTCGAAGTCGTCATCCATCCGCA
ATCCGTGATACACAGCATGGTGCGCTACCGCGACGGCTCCGTGTTGGCGCAACTGGGCAATCCCGATATGCGAACGCCCA
TCGCTTATTGTTTGGGTTTGCCCGAGCGCATCGATTCGGGTGTCGGCGACCTGGATTTCGACGCATTGTCCGCGCTGACC
TTCCAAAAGCCCGACTTTGACCGCTTCCCCTGCCTGAAGCTCGCCTATGAAGCCATGAACGCAGGCGGAGCCGCGCCCTG
CGTATTGAACGCCGCCAACGAAGCCGCCGTCGCCGCCTTTTTGGACGGGCAGATTAAGTTTACCGACATTGCCAAAACCG
TCGCCCATTGTCTCGCACAAGACTTTTCAGACGGCATAGGCGACATAGGGGGGCTCTTGGCGCAAGATGCCCGGACACGC
GCACAAGCGCGGGCATTTATCGGCACACTGCGCTGA

Upstream 100 bases:

>100_bases
AACCTGCTGTCCGGACACGGCGGCGTGTTCGACCGTACCGACAGCCTGATTGCCGTTATCAGCGTCTATGCGGCGATGAT
GTCGGTTTTAAATTGATTCT

Downstream 100 bases:

>100_bases
TGCCGTCCGAACACCGTTATCAAAGGAAAACCATTTGCACACCCTTCTAGCTTTTATCTTCGCCATCCTGATTTTGGTCA
GCCTGCACGAGTTCGGACAC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPSENASDGIRYKVIPIMTPQVLTILGSTGSIGESTLDVVSLHPEKFRVFALAGHKQVEKLAVQCRTFRPEYAVVADAEH
AARLEALLKGDGTATQVLHGAQALVDVASADEVSGVMCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARA
NGAAVLPVDSEHNAVFQVLPRDYAGRLNEHGIASIILTASGGPFLTADLNTFDSITPDQAVKHPNWRMGRKISVDSATMM
NKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAYCLGLPERIDSGVGDLDFDALSALT
FQKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAAVAAFLDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTR
AQARAFIGTLR

Sequences:

>Translated_411_residues
MPSENASDGIRYKVIPIMTPQVLTILGSTGSIGESTLDVVSLHPEKFRVFALAGHKQVEKLAVQCRTFRPEYAVVADAEH
AARLEALLKGDGTATQVLHGAQALVDVASADEVSGVMCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARA
NGAAVLPVDSEHNAVFQVLPRDYAGRLNEHGIASIILTASGGPFLTADLNTFDSITPDQAVKHPNWRMGRKISVDSATMM
NKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAYCLGLPERIDSGVGDLDFDALSALT
FQKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAAVAAFLDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTR
AQARAFIGTLR
>Mature_410_residues
PSENASDGIRYKVIPIMTPQVLTILGSTGSIGESTLDVVSLHPEKFRVFALAGHKQVEKLAVQCRTFRPEYAVVADAEHA
ARLEALLKGDGTATQVLHGAQALVDVASADEVSGVMCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARAN
GAAVLPVDSEHNAVFQVLPRDYAGRLNEHGIASIILTASGGPFLTADLNTFDSITPDQAVKHPNWRMGRKISVDSATMMN
KGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAYCLGLPERIDSGVGDLDFDALSALTF
QKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAAVAAFLDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTRA
QARAFIGTLR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=56.5989847715736, Blast_Score=407, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43672; Mature: 43541

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSENASDGIRYKVIPIMTPQVLTILGSTGSIGESTLDVVSLHPEKFRVFALAGHKQVEK
CCCCCCCCCCEEEEEEECCCHHHEEECCCCCCCCCHHHHEEECCCCEEEEEECCHHHHHH
LAVQCRTFRPEYAVVADAEHAARLEALLKGDGTATQVLHGAQALVDVASADEVSGVMCAI
HHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAVFQVLP
HHHHCCCHHHHHHHCCCEEEEECCCEEEEECHHHHHHHCCCCEEEEEECCCCCCEEEECC
RDYAGRLNEHGIASIILTASGGPFLTADLNTFDSITPDQAVKHPNWRMGRKISVDSATMM
CHHHCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCCCEEECCHHHHH
NKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAYCLGL
HHCHHHEEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCC
PERIDSGVGDLDFDALSALTFQKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAAVAAF
HHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
LDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTRAQARAFIGTLR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSENASDGIRYKVIPIMTPQVLTILGSTGSIGESTLDVVSLHPEKFRVFALAGHKQVEK
CCCCCCCCCEEEEEEECCCHHHEEECCCCCCCCCHHHHEEECCCCEEEEEECCHHHHHH
LAVQCRTFRPEYAVVADAEHAARLEALLKGDGTATQVLHGAQALVDVASADEVSGVMCAI
HHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAVFQVLP
HHHHCCCHHHHHHHCCCEEEEECCCEEEEECHHHHHHHCCCCEEEEEECCCCCCEEEECC
RDYAGRLNEHGIASIILTASGGPFLTADLNTFDSITPDQAVKHPNWRMGRKISVDSATMM
CHHHCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCCCEEECCHHHHH
NKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAYCLGL
HHCHHHEEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCC
PERIDSGVGDLDFDALSALTFQKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAAVAAF
HHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
LDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTRAQARAFIGTLR
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA