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The map label for this gene is fabF1 [H]

Identifier: 161870844

GI number: 161870844

Start: 1973838

End: 1975085

Strand: Direct

Name: fabF1 [H]

Synonym: NMCC_1926

Alternate gene names: 161870844

Gene position: 1973838-1975085 (Clockwise)

Preceding gene: 161870843

Following gene: 161870845

Centisome position: 91.66

GC content: 59.94

Gene sequence:

>1248_bases
ATGAGTCAGAGAAGAGTAGTCATTACAGGCTTAGGTCAGGTTTCCCCTGTCGGCAACACTGTCGCAGAGGCTTGGGACAC
CCTGCTCGCCGGCAAAAGCGGCATCGGCGCGATTACCCGCTTTGACGCATCCGACATCAACAGCCGTGTCGCCGGCGAAG
TGCGCGGTTTCGACATCGGACAATACATCAGCGCGAAAGAAGCGCGCCGGATGGACGTATTCATCCACTACGGCATTGCC
GCCGCATTGCAGGCAATCGCCGATTCGGGCTTGGACGATGTGGAAAACCTCGACAAAGACCGCATCGGCGTGAACATCGG
TTCCGGCATCGGCGGACTGCCCAGCATCGAGGTCACCGGCAAAGCCGTAATCGAAGGCGGCGCGCGCAAAATCAACCCTT
TCTTTATCCCCGGTTCGCTGATCAACCTGATTTCCGGACACGTTACCATCCTCAAAGGCTACCGCGGCCCGAGCTACGGG
ATGGTTTCCGCCTGTACCACCGGCGCGCACGCCATCGGCAATTCCGCCCGACTGATCAAATACGGCGACGCGGACATAAT
GGTTGCCGGCGGCGCGGAAGGCGCAATCAGCACTTTGGGCGTGGGCGGTTTTGCCGCGATGAAAGCCCTCTCCACCCGCA
ACGACGACCCCGCCACCGCTTCCCGTCCGTGGGACAAAGGCCGCGACGGCTTCGTTATCGGCGAAGGCGCGGGCATATTG
GTGTTGGAAGAATTGGAACACGCCAAAAAACGCGGCGCGAAAATCTACGCCGAAATCGTCGGCTTCGGCATGAGTTCCGA
TGCTTACCATATCACCGCGCCGAACGAAGAAGGCCCCGCCCTTGCCGTTACCCGCGCGCTGAAAGATGCCGGCATCAATC
CCGAAGACGTGGATTACGTCAACGCGCACGGCACGTCCACCCCCTTGGGCGATGCCAACGAAACCAAAGCCCTCAAACGC
GCATTCGGCGAACACGCCTACAAAACCGTCGTCAGCTCGACCAAATCCATGACCGGCCACCTGCTCGGCGCGGCGGGCGG
CGTGGAGGCCGTGTACAGCATTTTGGCGATACACGACGGCAAAATCCCGCCGACCATCAACATTTTTGAACAAGACGTTG
AAGCCGGCTGCGATTTGGACTACTGCGCCAACGAAGCGCGCGACGCGGAAATCGACGTTGCCATTTCCAACTCCTTCGGC
TTCGGCGGCACCAACGGCACGCTGGTGTTCAAACGCTTCAAAGGCTGA

Upstream 100 bases:

>100_bases
CTTATATGGCAAACTGTTTGAACCCCTGCCGCAAATTACAGACGGCATCTGCACGACAGCCGCATATGCCCCCATTCCGA
CAACCAACAGCGAGGTTATC

Downstream 100 bases:

>100_bases
TTCCGCAAAGCCGCCGCCGACATCGAAATGCCGTCTGAAACCGTTTCAGACGGCATTTTTATAGTGATTAACAAAAATCA
GGACAAGGCGGCGAGCCGCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSQRRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIGQYISAKEARRMDVFIHYGIA
AALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTGKAVIEGGARKINPFFIPGSLINLISGHVTILKGYRGPSYG
MVSACTTGAHAIGNSARLIKYGDADIMVAGGAEGAISTLGVGGFAAMKALSTRNDDPATASRPWDKGRDGFVIGEGAGIL
VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYVNAHGTSTPLGDANETKALKR
AFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDGKIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFG
FGGTNGTLVFKRFKG

Sequences:

>Translated_415_residues
MSQRRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIGQYISAKEARRMDVFIHYGIA
AALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTGKAVIEGGARKINPFFIPGSLINLISGHVTILKGYRGPSYG
MVSACTTGAHAIGNSARLIKYGDADIMVAGGAEGAISTLGVGGFAAMKALSTRNDDPATASRPWDKGRDGFVIGEGAGIL
VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYVNAHGTSTPLGDANETKALKR
AFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDGKIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFG
FGGTNGTLVFKRFKG
>Mature_414_residues
SQRRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIGQYISAKEARRMDVFIHYGIAA
ALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTGKAVIEGGARKINPFFIPGSLINLISGHVTILKGYRGPSYGM
VSACTTGAHAIGNSARLIKYGDADIMVAGGAEGAISTLGVGGFAAMKALSTRNDDPATASRPWDKGRDGFVIGEGAGILV
LEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYVNAHGTSTPLGDANETKALKRA
FGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDGKIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFGF
GGTNGTLVFKRFKG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=47.3684210526316, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=53.3783783783784, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=23.7875288683603, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=60.4819277108434, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=42.1686746987952, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=40.8114558472554, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71983535, Length=269, Percent_Identity=44.9814126394052, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI212642053, Length=433, Percent_Identity=24.4803695150115, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=23.7864077669903, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=37.8318584070796, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=44.1037735849057, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI19920632, Length=372, Percent_Identity=23.9247311827957, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221330659, Length=373, Percent_Identity=23.8605898123324, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=23.4883720930233, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43130; Mature: 42999

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIG
CCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHCHHHHCCCCCCCHH
QYISAKEARRMDVFIHYGIAAALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTG
HHHHHHHHCEEEEEEEHHHHHHHHHHHHCCCHHHHHCCCHHCCEEECCCCCCCCCEEECC
KAVIEGGARKINPFFIPGSLINLISGHVTILKGYRGPSYGMVSACTTGAHAIGNSARLIK
CEEECCCCEECCCEEECHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCHHHCCCCCEEEE
YGDADIMVAGGAEGAISTLGVGGFAAMKALSTRNDDPATASRPWDKGRDGFVIGEGAGIL
ECCCEEEEECCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYV
EEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEE
NAHGTSTPLGDANETKALKRAFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCC
KIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFGFGGTNGTLVFKRFKG
CCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SQRRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIG
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHCHHHHCCCCCCCHH
QYISAKEARRMDVFIHYGIAAALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTG
HHHHHHHHCEEEEEEEHHHHHHHHHHHHCCCHHHHHCCCHHCCEEECCCCCCCCCEEECC
KAVIEGGARKINPFFIPGSLINLISGHVTILKGYRGPSYGMVSACTTGAHAIGNSARLIK
CEEECCCCEECCCEEECHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCHHHCCCCCEEEE
YGDADIMVAGGAEGAISTLGVGGFAAMKALSTRNDDPATASRPWDKGRDGFVIGEGAGIL
ECCCEEEEECCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYV
EEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEE
NAHGTSTPLGDANETKALKRAFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCC
KIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFGFGGTNGTLVFKRFKG
CCCCCHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]