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The map label for this gene is uvrD [H]

Identifier: 161870830

GI number: 161870830

Start: 1960009

End: 1962093

Strand: Reverse

Name: uvrD [H]

Synonym: NMCC_1912

Alternate gene names: 161870830

Gene position: 1962093-1960009 (Counterclockwise)

Preceding gene: 161870838

Following gene: 161870829

Centisome position: 91.12

GC content: 56.98

Gene sequence:

>2085_bases
GTGCTGACCACGCGTATCGCATGGCTGTTGCAAACCGGTCAGGCAAGCGTGCATAGCATTATGGCGGTAACGTTTACCAA
TAAAGCCGCCAAAGAAATGCAGACCCGTTTGGGCGCAATGATTCCCGTCAACGTCCGCGCCATGTGGCTCGGCACGTTTC
ACGGTCTCTGCCACCGCTTTTTGCGCCTGCACCACCGCGACGCAGGCCTGCCGTCTTCCTTTCAAATTCTCGACAGCGGC
GACCAGCTTTCCCTCATCAAACGCCTGCTCAAAAGCCTCAACATCGCCGAAGAAATCATCGCACCGCGTTCGCTGCAAGG
CTTTATCAACGCGCAAAAAGAATCCGGTTTGCGCGCTTCCGTGTTGAGCGCGCCCGACCCGCACACAAGCCGCATGATCG
AATGCTACGCCGAATACGACAAAATCTGCCAACGCGAAGGCGTGGTCGATTTTGCCGAACTCATGCTCCGCAGCTACGAA
ATGCTGCAAAGCAACGAAATCCTGCGCCAGCATTACCAAAACCGCTTCAACCACATTCTCGTCGACGAGTTCCAAGACAC
CAACAAACTGCAATACGCCTGGCTCAAACTCATGGCGGGCGGAAACGCAGCGGTATTTGCCGTCGGCGACGACGACCAAA
GCATTTACCGTTTCCGTGGCGCAAACGTTGGCAATATGACCGCGCTGATGGAAGAATTCCACATCGACGCGCCCGTCAAA
CTCGAACAAAACTACCGCTCCGTCGGCAACATCCTTGCCGCCGCCAACGCTGTTATCGAAAACAACGACGAACGCCTCGG
CAAAAACCTGCGCACCGACGCCGAAGCAGGCGACAAAATTCGCTACTACTCCGCCTTTACCGACCTCGAAGAAGCCCGGT
TCATCGTGGACGAAACCAAAGCCCTCGAACGCGAAGGCTGGGATTTGGACGAAATCGCCGTCCTCTACCGCAGCAACGCC
CAATCGCGCGTCATCGAACAAAGCCTGTTCCGCAGCGGCATCCCCTACAAAATCTACGGCGGCTTGCGCTTTTACGAACG
CCAAGAAATCAAACACGCGCTCGCCTACCTACGCCTCGCCGTCAATCCCGACGACGACAACGCCCTCTTGCGTGTCATCA
ACTTCCCACCGCGCGGCATCGGCGCACGCACCGTCGAGAACCTTCAGACGGCCTCAAACGAACAAGGCATCACCCTCTGG
CAAGCCGCCTGCAACGCCGGCGCGAAAGCCGCCAAAATCGCCGCCTTCGTCCGCCTGATTGAAGCACTGCGCAACCAAGT
CGGACAACTGCCCCTGTCCGAAATCATCGTCGGCATCCTCAAAGACAGCGGCCTGACCGAACACTACCGAACCCAAAAAG
GCGACAACCAAGACCGCCTCGACAACCTTGACGAACTCGTCAACGCCGCCATCGAGTTCAAACCCGAAGACAGCAACTTT
GAAACCCTGCCCGAAAACATTTCAGACGACCCCGCCTTCCCCATCCTCGCCTTCCTCAGCAACGCCGCCCTCGAATCCGG
CGAAAACCAAGCAGGCGCAGGTGAAAAAGCCGTCCAACTCATGACCGTCCACGCCGCCAAAGGCTTGGAATTCAACGCCG
TCTTCCTCACCGGCATGGAAGAAGGCCGCTTCCCCAGCGAAATGAGCCTTGCCGAACGCGGCGGCCTCGAAGAAGAACGC
CGCCTCATGTACGTCGCCATCACCCGCGCCCGCAAACGCCTCTACATCACCATGGCACAGCAACGCATGCTGCACGGACA
AACCCAATTCGGCATCGTCTCCCGCTTCGTCGAAGAAATCCCACCCGAAGTATTGCACTACCTGTCCGTCAAAAAGCCTG
CCTACGACAGTTACGGCAACACGCGTCAAACTGCCACGTTCAAAGACAAAATCATCGACGACTACAAACAGCCGCAAACC
TACGCAGGCTTCCGTATCGGACAAAACGTCCGCCACGCCAAATTCGGCACCGGCGTGATTATCGATGCCGCAGATAAAGG
CGAATCCGCCCGACTGACCATCAACTTCGGCAAACAGGGCGTGAAAGAGTTGGATACCAAGTTTGCGAAATTGGAAGCGA
TGTAA

Upstream 100 bases:

>100_bases
CAACCTGCTGCAAGGCTTGAACCCTGAACAACTTTCCGCCGTAACCTGGCCGCCGCAATCCGCCCTTGTGCTGGCAGGCG
CGGGCAGCGGCAAAACGCGC

Downstream 100 bases:

>100_bases
ATTTGAAATGCAGGCTGGATACTCGTATCCGACAAAAATATTTGACGCGTCTATCGTTTCCGAAAAACCGCTGTTGGAAA
ATGTCGGATTCGAGAATCCG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MLTTRIAWLLQTGQASVHSIMAVTFTNKAAKEMQTRLGAMIPVNVRAMWLGTFHGLCHRFLRLHHRDAGLPSSFQILDSG
DQLSLIKRLLKSLNIAEEIIAPRSLQGFINAQKESGLRASVLSAPDPHTSRMIECYAEYDKICQREGVVDFAELMLRSYE
MLQSNEILRQHYQNRFNHILVDEFQDTNKLQYAWLKLMAGGNAAVFAVGDDDQSIYRFRGANVGNMTALMEEFHIDAPVK
LEQNYRSVGNILAAANAVIENNDERLGKNLRTDAEAGDKIRYYSAFTDLEEARFIVDETKALEREGWDLDEIAVLYRSNA
QSRVIEQSLFRSGIPYKIYGGLRFYERQEIKHALAYLRLAVNPDDDNALLRVINFPPRGIGARTVENLQTASNEQGITLW
QAACNAGAKAAKIAAFVRLIEALRNQVGQLPLSEIIVGILKDSGLTEHYRTQKGDNQDRLDNLDELVNAAIEFKPEDSNF
ETLPENISDDPAFPILAFLSNAALESGENQAGAGEKAVQLMTVHAAKGLEFNAVFLTGMEEGRFPSEMSLAERGGLEEER
RLMYVAITRARKRLYITMAQQRMLHGQTQFGIVSRFVEEIPPEVLHYLSVKKPAYDSYGNTRQTATFKDKIIDDYKQPQT
YAGFRIGQNVRHAKFGTGVIIDAADKGESARLTINFGKQGVKELDTKFAKLEAM

Sequences:

>Translated_694_residues
MLTTRIAWLLQTGQASVHSIMAVTFTNKAAKEMQTRLGAMIPVNVRAMWLGTFHGLCHRFLRLHHRDAGLPSSFQILDSG
DQLSLIKRLLKSLNIAEEIIAPRSLQGFINAQKESGLRASVLSAPDPHTSRMIECYAEYDKICQREGVVDFAELMLRSYE
MLQSNEILRQHYQNRFNHILVDEFQDTNKLQYAWLKLMAGGNAAVFAVGDDDQSIYRFRGANVGNMTALMEEFHIDAPVK
LEQNYRSVGNILAAANAVIENNDERLGKNLRTDAEAGDKIRYYSAFTDLEEARFIVDETKALEREGWDLDEIAVLYRSNA
QSRVIEQSLFRSGIPYKIYGGLRFYERQEIKHALAYLRLAVNPDDDNALLRVINFPPRGIGARTVENLQTASNEQGITLW
QAACNAGAKAAKIAAFVRLIEALRNQVGQLPLSEIIVGILKDSGLTEHYRTQKGDNQDRLDNLDELVNAAIEFKPEDSNF
ETLPENISDDPAFPILAFLSNAALESGENQAGAGEKAVQLMTVHAAKGLEFNAVFLTGMEEGRFPSEMSLAERGGLEEER
RLMYVAITRARKRLYITMAQQRMLHGQTQFGIVSRFVEEIPPEVLHYLSVKKPAYDSYGNTRQTATFKDKIIDDYKQPQT
YAGFRIGQNVRHAKFGTGVIIDAADKGESARLTINFGKQGVKELDTKFAKLEAM
>Mature_694_residues
MLTTRIAWLLQTGQASVHSIMAVTFTNKAAKEMQTRLGAMIPVNVRAMWLGTFHGLCHRFLRLHHRDAGLPSSFQILDSG
DQLSLIKRLLKSLNIAEEIIAPRSLQGFINAQKESGLRASVLSAPDPHTSRMIECYAEYDKICQREGVVDFAELMLRSYE
MLQSNEILRQHYQNRFNHILVDEFQDTNKLQYAWLKLMAGGNAAVFAVGDDDQSIYRFRGANVGNMTALMEEFHIDAPVK
LEQNYRSVGNILAAANAVIENNDERLGKNLRTDAEAGDKIRYYSAFTDLEEARFIVDETKALEREGWDLDEIAVLYRSNA
QSRVIEQSLFRSGIPYKIYGGLRFYERQEIKHALAYLRLAVNPDDDNALLRVINFPPRGIGARTVENLQTASNEQGITLW
QAACNAGAKAAKIAAFVRLIEALRNQVGQLPLSEIIVGILKDSGLTEHYRTQKGDNQDRLDNLDELVNAAIEFKPEDSNF
ETLPENISDDPAFPILAFLSNAALESGENQAGAGEKAVQLMTVHAAKGLEFNAVFLTGMEEGRFPSEMSLAERGGLEEER
RLMYVAITRARKRLYITMAQQRMLHGQTQFGIVSRFVEEIPPEVLHYLSVKKPAYDSYGNTRQTATFKDKIIDDYKQPQT
YAGFRIGQNVRHAKFGTGVIIDAADKGESARLTINFGKQGVKELDTKFAKLEAM

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=704, Percent_Identity=47.4431818181818, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=625, Percent_Identity=34.24, Blast_Score=315, Evalue=6e-87,
Organism=Escherichia coli, GI1787196, Length=334, Percent_Identity=27.2455089820359, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322369, Length=702, Percent_Identity=26.3532763532764, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324477, Length=559, Percent_Identity=24.6869409660107, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77944; Mature: 77944

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTRIAWLLQTGQASVHSIMAVTFTNKAAKEMQTRLGAMIPVNVRAMWLGTFHGLCHRF
CCCHHHHHHHHCCCHHHHHEEEEEECCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHH
LRLHHRDAGLPSSFQILDSGDQLSLIKRLLKSLNIAEEIIAPRSLQGFINAQKESGLRAS
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCEEE
VLSAPDPHTSRMIECYAEYDKICQREGVVDFAELMLRSYEMLQSNEILRQHYQNRFNHIL
ECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
VDEFQDTNKLQYAWLKLMAGGNAAVFAVGDDDQSIYRFRGANVGNMTALMEEFHIDAPVK
EECCCCCCHHHHHHHHHEECCCEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCE
LEQNYRSVGNILAAANAVIENNDERLGKNLRTDAEAGDKIRYYSAFTDLEEARFIVDETK
EHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEHHHHCHHHHHHHHHHHH
ALEREGWDLDEIAVLYRSNAQSRVIEQSLFRSGIPYKIYGGLRFYERQEIKHALAYLRLA
HHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHEE
VNPDDDNALLRVINFPPRGIGARTVENLQTASNEQGITLWQAACNAGAKAAKIAAFVRLI
ECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
EALRNQVGQLPLSEIIVGILKDSGLTEHYRTQKGDNQDRLDNLDELVNAAIEFKPEDSNF
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCC
ETLPENISDDPAFPILAFLSNAALESGENQAGAGEKAVQLMTVHAAKGLEFNAVFLTGME
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEHHCCCEEEEEEEECCC
EGRFPSEMSLAERGGLEEERRLMYVAITRARKRLYITMAQQRMLHGQTQFGIVSRFVEEI
CCCCCCHHHHHHHCCCCHHHHEEHEEEHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHC
PPEVLHYLSVKKPAYDSYGNTRQTATFKDKIIDDYKQPQTYAGFRIGQNVRHAKFGTGVI
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCHHCCCCCCCCCCCCEE
IDAADKGESARLTINFGKQGVKELDTKFAKLEAM
EECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTTRIAWLLQTGQASVHSIMAVTFTNKAAKEMQTRLGAMIPVNVRAMWLGTFHGLCHRF
CCCHHHHHHHHCCCHHHHHEEEEEECCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHH
LRLHHRDAGLPSSFQILDSGDQLSLIKRLLKSLNIAEEIIAPRSLQGFINAQKESGLRAS
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCEEE
VLSAPDPHTSRMIECYAEYDKICQREGVVDFAELMLRSYEMLQSNEILRQHYQNRFNHIL
ECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
VDEFQDTNKLQYAWLKLMAGGNAAVFAVGDDDQSIYRFRGANVGNMTALMEEFHIDAPVK
EECCCCCCHHHHHHHHHEECCCEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCE
LEQNYRSVGNILAAANAVIENNDERLGKNLRTDAEAGDKIRYYSAFTDLEEARFIVDETK
EHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEHHHHCHHHHHHHHHHHH
ALEREGWDLDEIAVLYRSNAQSRVIEQSLFRSGIPYKIYGGLRFYERQEIKHALAYLRLA
HHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHEE
VNPDDDNALLRVINFPPRGIGARTVENLQTASNEQGITLWQAACNAGAKAAKIAAFVRLI
ECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
EALRNQVGQLPLSEIIVGILKDSGLTEHYRTQKGDNQDRLDNLDELVNAAIEFKPEDSNF
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCC
ETLPENISDDPAFPILAFLSNAALESGENQAGAGEKAVQLMTVHAAKGLEFNAVFLTGME
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEHHCCCEEEEEEEECCC
EGRFPSEMSLAERGGLEEERRLMYVAITRARKRLYITMAQQRMLHGQTQFGIVSRFVEEI
CCCCCCHHHHHHHCCCCHHHHEEHEEEHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHC
PPEVLHYLSVKKPAYDSYGNTRQTATFKDKIIDDYKQPQTYAGFRIGQNVRHAKFGTGVI
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCHHCCCCCCCCCCCCEE
IDAADKGESARLTINFGKQGVKELDTKFAKLEAM
EECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]