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The map label for this gene is ispA [H]

Identifier: 161870803

GI number: 161870803

Start: 1933871

End: 1934767

Strand: Direct

Name: ispA [H]

Synonym: NMCC_1885

Alternate gene names: 161870803

Gene position: 1933871-1934767 (Clockwise)

Preceding gene: 161870802

Following gene: 161870827

Centisome position: 89.8

GC content: 57.86

Gene sequence:

>897_bases
TTGAATCCGACGAATGATTTGAAAGCGTGGCAACAGAGGGCGCAGGCACAGACAGAGCTGCTGCTGGAACGCTTTTTGCC
GTCTGAAAACGAAATCCCGCACACGCTGCACGAAGCGATGCGCTATGCGGCTTTGGACGGCGGCAAGCGTCTGCGTCCGA
TGCTGGTGCTGGCGGCTTCGGAATTGGGCGGGGTCGTGCATGAAGCAGTAGAACAGGCAATGGCGGCAATCGAAATGATC
CACGTCTATTCTTTGGTTCACGACGATATGCCGGCGATGGACAACGACAGCCTGCGGCGCGGCAAACCGACTTGCCATGT
GCAATACGACGAAGCCACCGCGCTACTGGTCGGCGACGCTTTGCAAACCCAAGCCTTCGACGTGTTAAGCCGTCCGACAG
AACTGCCCGCAGCACGCCAGTTGGCAATGTTGTCGGTGTTGGCGAAAGCGGGCGGCAGCGCGGGCATGGCGGGCGGTCAG
GCAATCGATTTGGCGAATGTCGGCAAACAAATGGTTCAAGCCGATTTGGAACAGATGCACAGCCTGAAAACGGGTGCGCT
AATCCGTGCGGCGGTTTTATTGGGGGCGACGGCGTGTCCTGATCTGTCAGATGCGGAACTTTCCGTATTGGACGCTTACG
CGGCAAAACTGGGGCTGGCGTTCCAAGTCATTGACGATGTGTTGGATTGTGAAGCGGACACGGCGACTTTGGGCAAAACG
GCGGGCAAAGACGCAGACAACGACAAGCCGACTTATGTGAAACTGATGGGCTTGGAAGCGGCGCGCTCATACGCACACAA
ACTGGTTGCCGAAGCGGTCGCGCTGCTCGAACCCTTCGGCGACAAAGCCCTGCGCCTGCGGCAGTTGGCAGAATTTGCAG
TCGCCCGCAAATATTAA

Upstream 100 bases:

>100_bases
CAGGAAGGCAACGAGCTGGTCAGATACTGCCAAACCAAGCTGGCGCAAGTCGAACAGAAATTACAGGTTTTGGATGCGGA
CGGGCTGAAGGAGTTGAACC

Downstream 100 bases:

>100_bases
AACCGGCGTATATCGCCGGCTGAAACGTGCCGGCACAGCGATGCCGGCCTGCACTTGAATGAAACAAATGCCGTCTGAAC
AGGTTTCAGACGGCATTCCT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNPTNDLKAWQQRAQAQTELLLERFLPSENEIPHTLHEAMRYAALDGGKRLRPMLVLAASELGGVVHEAVEQAMAAIEMI
HVYSLVHDDMPAMDNDSLRRGKPTCHVQYDEATALLVGDALQTQAFDVLSRPTELPAARQLAMLSVLAKAGGSAGMAGGQ
AIDLANVGKQMVQADLEQMHSLKTGALIRAAVLLGATACPDLSDAELSVLDAYAAKLGLAFQVIDDVLDCEADTATLGKT
AGKDADNDKPTYVKLMGLEAARSYAHKLVAEAVALLEPFGDKALRLRQLAEFAVARKY

Sequences:

>Translated_298_residues
MNPTNDLKAWQQRAQAQTELLLERFLPSENEIPHTLHEAMRYAALDGGKRLRPMLVLAASELGGVVHEAVEQAMAAIEMI
HVYSLVHDDMPAMDNDSLRRGKPTCHVQYDEATALLVGDALQTQAFDVLSRPTELPAARQLAMLSVLAKAGGSAGMAGGQ
AIDLANVGKQMVQADLEQMHSLKTGALIRAAVLLGATACPDLSDAELSVLDAYAAKLGLAFQVIDDVLDCEADTATLGKT
AGKDADNDKPTYVKLMGLEAARSYAHKLVAEAVALLEPFGDKALRLRQLAEFAVARKY
>Mature_298_residues
MNPTNDLKAWQQRAQAQTELLLERFLPSENEIPHTLHEAMRYAALDGGKRLRPMLVLAASELGGVVHEAVEQAMAAIEMI
HVYSLVHDDMPAMDNDSLRRGKPTCHVQYDEATALLVGDALQTQAFDVLSRPTELPAARQLAMLSVLAKAGGSAGMAGGQ
AIDLANVGKQMVQADLEQMHSLKTGALIRAAVLLGATACPDLSDAELSVLDAYAAKLGLAFQVIDDVLDCEADTATLGKT
AGKDADNDKPTYVKLMGLEAARSYAHKLVAEAVALLEPFGDKALRLRQLAEFAVARKY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=223, Percent_Identity=31.390134529148, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786623, Length=289, Percent_Identity=48.7889273356401, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1789578, Length=219, Percent_Identity=36.0730593607306, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31971; Mature: 31971

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTNDLKAWQQRAQAQTELLLERFLPSENEIPHTLHEAMRYAALDGGKRLRPMLVLAAS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELGGVVHEAVEQAMAAIEMIHVYSLVHDDMPAMDNDSLRRGKPTCHVQYDEATALLVGDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCEEHHHHH
LQTQAFDVLSRPTELPAARQLAMLSVLAKAGGSAGMAGGQAIDLANVGKQMVQADLEQMH
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHH
SLKTGALIRAAVLLGATACPDLSDAELSVLDAYAAKLGLAFQVIDDVLDCEADTATLGKT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
AGKDADNDKPTYVKLMGLEAARSYAHKLVAEAVALLEPFGDKALRLRQLAEFAVARKY
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPTNDLKAWQQRAQAQTELLLERFLPSENEIPHTLHEAMRYAALDGGKRLRPMLVLAAS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELGGVVHEAVEQAMAAIEMIHVYSLVHDDMPAMDNDSLRRGKPTCHVQYDEATALLVGDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCEEHHHHH
LQTQAFDVLSRPTELPAARQLAMLSVLAKAGGSAGMAGGQAIDLANVGKQMVQADLEQMH
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHH
SLKTGALIRAAVLLGATACPDLSDAELSVLDAYAAKLGLAFQVIDDVLDCEADTATLGKT
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
AGKDADNDKPTYVKLMGLEAARSYAHKLVAEAVALLEPFGDKALRLRQLAEFAVARKY
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]