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The map label for this gene is phr [H]

Identifier: 161870775

GI number: 161870775

Start: 1900177

End: 1901478

Strand: Direct

Name: phr [H]

Synonym: NMCC_1857

Alternate gene names: 161870775

Gene position: 1900177-1901478 (Clockwise)

Preceding gene: 161870774

Following gene: 161870776

Centisome position: 88.24

GC content: 62.21

Gene sequence:

>1302_bases
ATGCCGTCTGAAACCGCCCGCCCCCTTTATGCGGACACGTGCGCCGCACACACGCTCGTCTGGTTCCGCCAAAACCTCCG
CATCCGCGACAACGCCGCCTTATGCGCCGCCGTTGCCGAAGGTTTGCCCGTTATCGGTATTTGGATTGACGATGCCGAAA
CAGACAACCCTCGCCGCGCCGCGTTCTACCGCCAATCCGCCGCCGAACTCGCCCAAGGGCTTGCAGGGCGCGGCATCCCG
CTCTACACGGCGGCATCGCCTGCCGAGCTCGTCCGGCTCGCCGTCCGCCTCAATATCCGCGCCGTCATCGCCGACGAATC
CCATACTTTTGCCGACAAACTCGCCGACAACGCCCTTTGGCATGAATTGGACAAACACGGCATCGCGTTAACCTTCGTCA
ACGACCGTGCCGTTTTCGGCAAAACCGACCTGATACCCGACGGCGGCACGGCACACACCGATTTCGACCGCTACCGCGAA
GTATGGCTCGACCGCTTTTCCAAGCAGCCCCCCGCCGGTCCGGACCTATTCGCGGCATACCGCCAACCCTTCCCCGAAAA
CCTTTCCGCCCCGCCGCCTGCCGCCCTTTCAGACGGCATCTTCCTGCCGCAAAACAGCGGCGAAACGGCGGCTTGGCGGC
AGTGGCGGCGGTTTCTCGAACAGGCGGATTCCTACTCCGTTTTAAAGGATTTCCCCTCGCGCAAACACACCTCGCTGATG
GGCGCGTATTTGAGTGCCGGCTGCATCTCGCCGCGCCTGCTCGCGCGGGAAAGCCTCGAACGCCGTCTGAACGCGTGGGC
GGACAACATCATCCGCCGCGATTTTTTCCTTCAACTTGCCTTGCAGCACACGGATGACGACCCTTCAGACGGCAATCCTG
AACACACCCTGCGCCTGACGCTTTGGCAGCAGGGCCAGACCGGCATTCCGATTATCGATGCCGCGATGCGCTGTTTGCAC
AAAACCGGCAGCCTCCACCCCGCCCTGAGACGCTTGAGCGCGGATTTTTTCTGCCACGTTTTAAACCTCCCCCGCCGCGA
AGGCGAGATATGGTTTGCCCGGCAGCTGACCGATTTCGATGCGGCAATCAACCAAGGCAACTGGTGGCTTGCCGCCTCAC
GGCACACCTGCCCCGACATTGCCGCCGCCTCATACCGTACCGACCCGGACGGTACTTTTATCAAACGGCACATTCCCGAA
CTCGCCCACCTGTCCGCCGACACCGTCCACACGCCTTGGCGGTTTGCCTGTTCGGTCGATACCCACGGCTATCCCGCCTA
TCCTGTCGCCGGTATTCCCTAA

Upstream 100 bases:

>100_bases
CTGAATGCCGTTTATGCGGACAGGGCGTTCTTAAGCGCGAAAGTCCGCAGCTTCATCGATTTTCTGAACGAAAAAATCGC
CAGCAGGAAAGGCTGCCGAA

Downstream 100 bases:

>100_bases
GCGGTACGGCAACCTAAAACAAATGCCGTCTGAACTTCCGTTTCAGACGGCATTGTGTCTGAATGACTCAATATCTTCCG
TTTTTTTCACTTTCAATAAT

Product: deoxyribodopyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MPSETARPLYADTCAAHTLVWFRQNLRIRDNAALCAAVAEGLPVIGIWIDDAETDNPRRAAFYRQSAAELAQGLAGRGIP
LYTAASPAELVRLAVRLNIRAVIADESHTFADKLADNALWHELDKHGIALTFVNDRAVFGKTDLIPDGGTAHTDFDRYRE
VWLDRFSKQPPAGPDLFAAYRQPFPENLSAPPPAALSDGIFLPQNSGETAAWRQWRRFLEQADSYSVLKDFPSRKHTSLM
GAYLSAGCISPRLLARESLERRLNAWADNIIRRDFFLQLALQHTDDDPSDGNPEHTLRLTLWQQGQTGIPIIDAAMRCLH
KTGSLHPALRRLSADFFCHVLNLPRREGEIWFARQLTDFDAAINQGNWWLAASRHTCPDIAAASYRTDPDGTFIKRHIPE
LAHLSADTVHTPWRFACSVDTHGYPAYPVAGIP

Sequences:

>Translated_433_residues
MPSETARPLYADTCAAHTLVWFRQNLRIRDNAALCAAVAEGLPVIGIWIDDAETDNPRRAAFYRQSAAELAQGLAGRGIP
LYTAASPAELVRLAVRLNIRAVIADESHTFADKLADNALWHELDKHGIALTFVNDRAVFGKTDLIPDGGTAHTDFDRYRE
VWLDRFSKQPPAGPDLFAAYRQPFPENLSAPPPAALSDGIFLPQNSGETAAWRQWRRFLEQADSYSVLKDFPSRKHTSLM
GAYLSAGCISPRLLARESLERRLNAWADNIIRRDFFLQLALQHTDDDPSDGNPEHTLRLTLWQQGQTGIPIIDAAMRCLH
KTGSLHPALRRLSADFFCHVLNLPRREGEIWFARQLTDFDAAINQGNWWLAASRHTCPDIAAASYRTDPDGTFIKRHIPE
LAHLSADTVHTPWRFACSVDTHGYPAYPVAGIP
>Mature_432_residues
PSETARPLYADTCAAHTLVWFRQNLRIRDNAALCAAVAEGLPVIGIWIDDAETDNPRRAAFYRQSAAELAQGLAGRGIPL
YTAASPAELVRLAVRLNIRAVIADESHTFADKLADNALWHELDKHGIALTFVNDRAVFGKTDLIPDGGTAHTDFDRYREV
WLDRFSKQPPAGPDLFAAYRQPFPENLSAPPPAALSDGIFLPQNSGETAAWRQWRRFLEQADSYSVLKDFPSRKHTSLMG
AYLSAGCISPRLLARESLERRLNAWADNIIRRDFFLQLALQHTDDDPSDGNPEHTLRLTLWQQGQTGIPIIDAAMRCLHK
TGSLHPALRRLSADFFCHVLNLPRREGEIWFARQLTDFDAAINQGNWWLAASRHTCPDIAAASYRTDPDGTFIKRHIPEL
AHLSADTVHTPWRFACSVDTHGYPAYPVAGIP

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=449, Percent_Identity=25.6124721603563, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI188536100, Length=464, Percent_Identity=24.1379310344828, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI188536103, Length=368, Percent_Identity=24.1847826086957, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786926, Length=443, Percent_Identity=28.6681715575621, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324962, Length=458, Percent_Identity=25.1091703056769, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137248, Length=214, Percent_Identity=32.2429906542056, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585455, Length=214, Percent_Identity=32.2429906542056, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648152, Length=194, Percent_Identity=32.4742268041237, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 48372; Mature: 48241

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSETARPLYADTCAAHTLVWFRQNLRIRDNAALCAAVAEGLPVIGIWIDDAETDNPRRA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHH
AFYRQSAAELAQGLAGRGIPLYTAASPAELVRLAVRLNIRAVIADESHTFADKLADNALW
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHH
HELDKHGIALTFVNDRAVFGKTDLIPDGGTAHTDFDRYREVWLDRFSKQPPAGPDLFAAY
HHHHHCCEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
RQPFPENLSAPPPAALSDGIFLPQNSGETAAWRQWRRFLEQADSYSVLKDFPSRKHTSLM
HCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
GAYLSAGCISPRLLARESLERRLNAWADNIIRRDFFLQLALQHTDDDPSDGNPEHTLRLT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LWQQGQTGIPIIDAAMRCLHKTGSLHPALRRLSADFFCHVLNLPRREGEIWFARQLTDFD
EEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHH
AAINQGNWWLAASRHTCPDIAAASYRTDPDGTFIKRHIPELAHLSADTVHTPWRFACSVD
HHHCCCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECC
THGYPAYPVAGIP
CCCCCCCCCCCCC
>Mature Secondary Structure 
PSETARPLYADTCAAHTLVWFRQNLRIRDNAALCAAVAEGLPVIGIWIDDAETDNPRRA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHH
AFYRQSAAELAQGLAGRGIPLYTAASPAELVRLAVRLNIRAVIADESHTFADKLADNALW
HHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHH
HELDKHGIALTFVNDRAVFGKTDLIPDGGTAHTDFDRYREVWLDRFSKQPPAGPDLFAAY
HHHHHCCEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
RQPFPENLSAPPPAALSDGIFLPQNSGETAAWRQWRRFLEQADSYSVLKDFPSRKHTSLM
HCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHH
GAYLSAGCISPRLLARESLERRLNAWADNIIRRDFFLQLALQHTDDDPSDGNPEHTLRLT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LWQQGQTGIPIIDAAMRCLHKTGSLHPALRRLSADFFCHVLNLPRREGEIWFARQLTDFD
EEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHH
AAINQGNWWLAASRHTCPDIAAASYRTDPDGTFIKRHIPELAHLSADTVHTPWRFACSVD
HHHCCCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECC
THGYPAYPVAGIP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]