Click here to switch to the map view.

The map label for this gene is prpC [H]

Identifier: 161870644

GI number: 161870644

Start: 1755865

End: 1757019

Strand: Reverse

Name: prpC [H]

Synonym: NMCC_1714

Alternate gene names: 161870644

Gene position: 1757019-1755865 (Counterclockwise)

Preceding gene: 161870645

Following gene: 161870643

Centisome position: 81.59

GC content: 51.95

Gene sequence:

>1155_bases
ATGACTGAAACTACTCAAACCCCGACCTTCAAACCTAAGAAATCCGTTGCGCTTTCAGGCGTTGCGGCCGGTAATACCGC
TTTGTGTACCGTTGGCCGTACCGGCAACGATTTGAGTTATCGCGGTTACGACATCTTGGATTTGGCACAAAAATGTGAGT
TTGAAGAAGTTGCCCACCTGCTGATTCACGGCCATTTACCCAACAAATTCGAGCTGGCCGCTTATAAAGCCAAGCTCAAA
TCCATGCGCGGCCTGCCTATCCGTGTGATTAAAGTTTTGGAAAGCCTGCCTGCACATACCCATCCGATGGACGTGATGCG
TACCGGCGTATCCATGCTGGGCTGTGTTCATCCTGAACGTGAAGGCCATCCGGAAAGCGAAGCGCGCGACATTGCCGACA
AACTGATCGCCAGCCTCGGCAGTATCCTCTTGTACTGGTATCAATATTCGCACAACGGCAAACGCATTGAAGTTGAAAGC
GAAGAAGAGACCATCGGCGGTCATTTCCTGCACCTGTTGCACGGCAAACGCCCAAGCGAATCACACATCAAAGCCATGCA
CGTTTCACTGATTCTGTATGCCGAACACGAGTTCAACGCTTCTACCTTTACCGCCCGCGTGATCGCCGGTACAGGCTCTG
ATATGTACTCCAGCATTACCGGAGCAATCGGCGCGTTGAAAGGTCCGAAACACGGCGGCGCGAACGAAGTGGCTTACGAT
ATTCAAAAACGCTACCGCAATGCCGACGAAGCTGAAGCCGACATCCGCGAACGCATCGGCCGCAAAGAAATCGTGATCGG
TTTCGGTCATCCGGTGTACACCATTTCCGACCCTCGCAACGTTGTCATTAAAGAAGTGGCACGCGGTTTGAGCAAAGAAA
CCGGCGATATGCGCCTCTTTGACATTGCCGAACGTTTGGAAAGCGTGATGTGGGAAGAGAAAAAAATGTTCCCGAATCTG
GACTGGTTCTCTGCCGTTTCCTACCAAAAATTGGGCGTACCGACCGCTATGTTCACACCGCTGTTCGTAATTTCCCGTAC
AACCGGTTGGAGCGCACACGTTCTTGAGCAACGCAAAGACGGCAAAATCATCCGTCCGAGCGCAAACTACACGGGCCCTG
AAGATTTGGCGTTTGTGGAGATTGAAGAACGCTGA

Upstream 100 bases:

>100_bases
TTGTTTCAAAAATGATTTACCGCTTTCAGACGGTCTTTCAACAAATCCGCATCGGTCGTCTGAAAACCCGAAACCCATAA
AAACACAAAGGAGAAATACC

Downstream 100 bases:

>100_bases
GACGGAACACAACCGTAGGAGACCACCAATCGGATTTCAGACGACGTGTAGCGCGGGCTTTGCCTGCGGAAAACTGAAAC
CCGCCTACGGTTCCGCTTTT

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTETTQTPTFKPKKSVALSGVAAGNTALCTVGRTGNDLSYRGYDILDLAQKCEFEEVAHLLIHGHLPNKFELAAYKAKLK
SMRGLPIRVIKVLESLPAHTHPMDVMRTGVSMLGCVHPEREGHPESEARDIADKLIASLGSILLYWYQYSHNGKRIEVES
EEETIGGHFLHLLHGKRPSESHIKAMHVSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALKGPKHGGANEVAYD
IQKRYRNADEAEADIRERIGRKEIVIGFGHPVYTISDPRNVVIKEVARGLSKETGDMRLFDIAERLESVMWEEKKMFPNL
DWFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKDGKIIRPSANYTGPEDLAFVEIEER

Sequences:

>Translated_384_residues
MTETTQTPTFKPKKSVALSGVAAGNTALCTVGRTGNDLSYRGYDILDLAQKCEFEEVAHLLIHGHLPNKFELAAYKAKLK
SMRGLPIRVIKVLESLPAHTHPMDVMRTGVSMLGCVHPEREGHPESEARDIADKLIASLGSILLYWYQYSHNGKRIEVES
EEETIGGHFLHLLHGKRPSESHIKAMHVSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALKGPKHGGANEVAYD
IQKRYRNADEAEADIRERIGRKEIVIGFGHPVYTISDPRNVVIKEVARGLSKETGDMRLFDIAERLESVMWEEKKMFPNL
DWFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKDGKIIRPSANYTGPEDLAFVEIEER
>Mature_383_residues
TETTQTPTFKPKKSVALSGVAAGNTALCTVGRTGNDLSYRGYDILDLAQKCEFEEVAHLLIHGHLPNKFELAAYKAKLKS
MRGLPIRVIKVLESLPAHTHPMDVMRTGVSMLGCVHPEREGHPESEARDIADKLIASLGSILLYWYQYSHNGKRIEVESE
EETIGGHFLHLLHGKRPSESHIKAMHVSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALKGPKHGGANEVAYDI
QKRYRNADEAEADIRERIGRKEIVIGFGHPVYTISDPRNVVIKEVARGLSKETGDMRLFDIAERLESVMWEEKKMFPNLD
WFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKDGKIIRPSANYTGPEDLAFVEIEER

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=334, Percent_Identity=25.1497005988024, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786527, Length=388, Percent_Identity=72.680412371134, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1786939, Length=357, Percent_Identity=30.2521008403361, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=347, Percent_Identity=24.7838616714697, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319850, Length=346, Percent_Identity=23.6994219653179, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324328, Length=346, Percent_Identity=25.1445086705202, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356863, Length=351, Percent_Identity=23.3618233618234, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24640124, Length=335, Percent_Identity=25.0746268656716, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640126, Length=335, Percent_Identity=25.0746268656716, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42816; Mature: 42685

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTQTPTFKPKKSVALSGVAAGNTALCTVGRTGNDLSYRGYDILDLAQKCEFEEVAHL
CCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHH
LIHGHLPNKFELAAYKAKLKSMRGLPIRVIKVLESLPAHTHPMDVMRTGVSMLGCVHPER
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
EGHPESEARDIADKLIASLGSILLYWYQYSHNGKRIEVESEEETIGGHFLHLLHGKRPSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCH
SHIKAMHVSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALKGPKHGGANEVAYD
HHHHEEEEEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
IQKRYRNADEAEADIRERIGRKEIVIGFGHPVYTISDPRNVVIKEVARGLSKETGDMRLF
HHHHHCCCCHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHH
DIAERLESVMWEEKKMFPNLDWFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKD
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCHHHHHHEEEEECCCCCHHHHHHHCCC
GKIIRPSANYTGPEDLAFVEIEER
CCEECCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TETTQTPTFKPKKSVALSGVAAGNTALCTVGRTGNDLSYRGYDILDLAQKCEFEEVAHL
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHH
LIHGHLPNKFELAAYKAKLKSMRGLPIRVIKVLESLPAHTHPMDVMRTGVSMLGCVHPER
HHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
EGHPESEARDIADKLIASLGSILLYWYQYSHNGKRIEVESEEETIGGHFLHLLHGKRPSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCH
SHIKAMHVSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALKGPKHGGANEVAYD
HHHHEEEEEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
IQKRYRNADEAEADIRERIGRKEIVIGFGHPVYTISDPRNVVIKEVARGLSKETGDMRLF
HHHHHCCCCHHHHHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHH
DIAERLESVMWEEKKMFPNLDWFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKD
HHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCHHHHHHEEEEECCCCCHHHHHHHCCC
GKIIRPSANYTGPEDLAFVEIEER
CCEECCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]