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The map label for this gene is mutT [H]

Identifier: 161870622

GI number: 161870622

Start: 1728516

End: 1729325

Strand: Reverse

Name: mutT [H]

Synonym: NMCC_1691

Alternate gene names: 161870622

Gene position: 1729325-1728516 (Counterclockwise)

Preceding gene: 161870623

Following gene: 161870621

Centisome position: 80.31

GC content: 59.75

Gene sequence:

>810_bases
ATGATTCAAGACACCCGACCCCTTATCCGCGTCGTTGCCGGCATCCTGCTCGATTCAGACGGCAACTACCTGCTCAGCTC
GCGCCCCGAAGGCAAACCCTATGCCGGATATTGGGAATTTGCCGGCGGCAAGGTCGAAGCGGGCGAAACCGACTTCCAAG
CCTTGCAACGCGAGTTTGAAGAAGAACTCGGCATCCGCATCCTTGCCGCCACGCCTTGGCTGACCAAAATCCATTCCTAC
GAACACGCCCGCGTCTGCCTGAAATTCCTATGGGTCAACCCCGACCAATGGACGGGCGAACCGCAATCGCGCGAAGGACA
GGCATGGTCTTGGCAGAAGGCGGGTGATTTTACCGTTGCCCCCATGCTGCCCGCCAACGGCGCGCTTTTGCGTTCGCTGT
CCGTCCCGCGCCGTTTGTACGGCAGCCTGAAAACGGGTTTGCACGGAGAAAACAGTATGGGCGCGTACCGCGTCCTGCCT
TTGGGTTCGGCAGAGGGAAGCGGTGCGAACGTTTTGATGGAGACGGCGCAATGGCAGGACAGACCCGAACACGCCGACAG
CGTGTGGATGGTGGTGCAGACCCGCGAACAATGGCGGCAGGCGCAGGAAAAGGGCGCGGATGCGGTCGTTTGGCGCGTGT
GCGATGATGTTCAGGCACAAGAGGCGGCAGAAGCCCTGCGGCAGGGCGTATCCGTGCCGCTCGTACTTGCAGCAAACGGA
CAGACGGTTGCACGTTATGGAAAACTATGGCTCGGATTGGGGGCGCACGCGGTGGTAAGGGATGAAACAATAGGGAAGAA
TCATGAATAA

Upstream 100 bases:

>100_bases
TGTCGTTGCCGAAAAATAATGCCGTCTGAAATGCGGCAAACCCGTTGACGGCATTGCTCGTCCCTCATTTGCACTCCGAC
CGACCAACCGCGTACCCGCC

Downstream 100 bases:

>100_bases
AAACCGTAAATTACTGCTTGCCGCACTGCTGCTGATTGCCTTTGCCGCCGTCAAGCTCGTTTTGTTGCAATGGTGGCAGG
CGCAGCAGCCGCAAGCCGTG

Product: mutator MutT (7,8-dihydro-8-oxoguanine-triphosphatase)

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MIQDTRPLIRVVAGILLDSDGNYLLSSRPEGKPYAGYWEFAGGKVEAGETDFQALQREFEEELGIRILAATPWLTKIHSY
EHARVCLKFLWVNPDQWTGEPQSREGQAWSWQKAGDFTVAPMLPANGALLRSLSVPRRLYGSLKTGLHGENSMGAYRVLP
LGSAEGSGANVLMETAQWQDRPEHADSVWMVVQTREQWRQAQEKGADAVVWRVCDDVQAQEAAEALRQGVSVPLVLAANG
QTVARYGKLWLGLGAHAVVRDETIGKNHE

Sequences:

>Translated_269_residues
MIQDTRPLIRVVAGILLDSDGNYLLSSRPEGKPYAGYWEFAGGKVEAGETDFQALQREFEEELGIRILAATPWLTKIHSY
EHARVCLKFLWVNPDQWTGEPQSREGQAWSWQKAGDFTVAPMLPANGALLRSLSVPRRLYGSLKTGLHGENSMGAYRVLP
LGSAEGSGANVLMETAQWQDRPEHADSVWMVVQTREQWRQAQEKGADAVVWRVCDDVQAQEAAEALRQGVSVPLVLAANG
QTVARYGKLWLGLGAHAVVRDETIGKNHE
>Mature_269_residues
MIQDTRPLIRVVAGILLDSDGNYLLSSRPEGKPYAGYWEFAGGKVEAGETDFQALQREFEEELGIRILAATPWLTKIHSY
EHARVCLKFLWVNPDQWTGEPQSREGQAWSWQKAGDFTVAPMLPANGALLRSLSVPRRLYGSLKTGLHGENSMGAYRVLP
LGSAEGSGANVLMETAQWQDRPEHADSVWMVVQTREQWRQAQEKGADAVVWRVCDDVQAQEAAEALRQGVSVPLVLAANG
QTVARYGKLWLGLGAHAVVRDETIGKNHE

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=131, Percent_Identity=39.6946564885496, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 29805; Mature: 29805

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQDTRPLIRVVAGILLDSDGNYLLSSRPEGKPYAGYWEFAGGKVEAGETDFQALQREFE
CCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHH
EELGIRILAATPWLTKIHSYEHARVCLKFLWVNPDQWTGEPQSREGQAWSWQKAGDFTVA
HHHCEEEEEECCHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCCCCCEECCCCCCEEEE
PMLPANGALLRSLSVPRRLYGSLKTGLHGENSMGAYRVLPLGSAEGSGANVLMETAQWQD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEECHHCCC
RPEHADSVWMVVQTREQWRQAQEKGADAVVWRVCDDVQAQEAAEALRQGVSVPLVLAANG
CCCCCCEEEEEEECHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECC
QTVARYGKLWLGLGAHAVVRDETIGKNHE
CCHHHHHHHHHCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MIQDTRPLIRVVAGILLDSDGNYLLSSRPEGKPYAGYWEFAGGKVEAGETDFQALQREFE
CCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHH
EELGIRILAATPWLTKIHSYEHARVCLKFLWVNPDQWTGEPQSREGQAWSWQKAGDFTVA
HHHCEEEEEECCHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCCCCCEECCCCCCEEEE
PMLPANGALLRSLSVPRRLYGSLKTGLHGENSMGAYRVLPLGSAEGSGANVLMETAQWQD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEEECHHCCC
RPEHADSVWMVVQTREQWRQAQEKGADAVVWRVCDDVQAQEAAEALRQGVSVPLVLAANG
CCCCCCEEEEEEECHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECC
QTVARYGKLWLGLGAHAVVRDETIGKNHE
CCHHHHHHHHHCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]