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The map label for this gene is glcA [H]

Identifier: 161870558

GI number: 161870558

Start: 1653330

End: 1653629

Strand: Direct

Name: glcA [H]

Synonym: NMCC_1624

Alternate gene names: 161870558

Gene position: 1653330-1653629 (Clockwise)

Preceding gene: 161870556

Following gene: 161870559

Centisome position: 76.78

GC content: 52.67

Gene sequence:

>300_bases
ATGCAACGTTGCTTTAATTGGTTTGACCACTATTGCCGACGATTAGAAAAATATTTTCGGAGATGTTCAATTATGGAAAC
TTGGGTTCAAAACTACACGGCAATCGGCGGCAGCCTGTATCTGACTGCCGCCGCCGCACTCTTACCCATCGTCTTTTTCT
TTGCCGCGCTGACCGTCCTGAAGCTGAAAGGCTATCAGGCGGGGCTTTATACGCTGCTGATTGCGCTTGCCGTTGCCGTA
TTCGGCTTCGGGATGCCGACGGGTATGGCGGTTTCTTCCCTGCCGCCGCAGCCGCATTGA

Upstream 100 bases:

>100_bases
GCAAATATTTGTTTTGACAGGATTTAAACAAAAGCTCCGATTCAAATCTGCCGAACCGCCCAAAAATATATTGACCTAAA
TATTAAAGTTTCGTAAAGTA

Downstream 100 bases:

>100_bases
CCCAACGCCCCTACGCCACACTGTATTTGACCGCGCATTACAAAATCGGCAAATCCACCCGCATCGGTTTGGACTTTGAA
AACGTGTTCAACAAACGCTA

Product: L-lactate permease-related protein

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 99; Mature: 99

Protein sequence:

>99_residues
MQRCFNWFDHYCRRLEKYFRRCSIMETWVQNYTAIGGSLYLTAAAALLPIVFFFAALTVLKLKGYQAGLYTLLIALAVAV
FGFGMPTGMAVSSLPPQPH

Sequences:

>Translated_99_residues
MQRCFNWFDHYCRRLEKYFRRCSIMETWVQNYTAIGGSLYLTAAAALLPIVFFFAALTVLKLKGYQAGLYTLLIALAVAV
FGFGMPTGMAVSSLPPQPH
>Mature_99_residues
MQRCFNWFDHYCRRLEKYFRRCSIMETWVQNYTAIGGSLYLTAAAALLPIVFFFAALTVLKLKGYQAGLYTLLIALAVAV
FGFGMPTGMAVSSLPPQPH

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=66, Percent_Identity=53.030303030303, Blast_Score=66, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 11146; Mature: 11146

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRCFNWFDHYCRRLEKYFRRCSIMETWVQNYTAIGGSLYLTAAAALLPIVFFFAALTVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLKGYQAGLYTLLIALAVAVFGFGMPTGMAVSSLPPQPH
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQRCFNWFDHYCRRLEKYFRRCSIMETWVQNYTAIGGSLYLTAAAALLPIVFFFAALTVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLKGYQAGLYTLLIALAVAVFGFGMPTGMAVSSLPPQPH
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]