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The map label for this gene is gluD [H]

Identifier: 161870344

GI number: 161870344

Start: 1409113

End: 1410129

Strand: Reverse

Name: gluD [H]

Synonym: NMCC_1388

Alternate gene names: 161870344

Gene position: 1410129-1409113 (Counterclockwise)

Preceding gene: 161870345

Following gene: 161870342

Centisome position: 65.48

GC content: 52.11

Gene sequence:

>1017_bases
GTGAATCTGGACGAAGTCAAAGCCCTGTCGATTTGGATGACCATCAAATGCTGCGTAGCGGGCATTCCTTACGGCGGCGG
CAAAGGCGGCGTTACCTTGGATCCGCGCGATTATTCCGAGGCGGAACTGGAACGCATCGCCCGCGCTTATTCCGAAGCCA
TTTCTCCGCTGATCGGCGAGAAAATCGATATTCCCGCACCTGATGTGAACACCAACGGCAAAATCATGTCTTGGATGGTT
GATGCCTATGAAAACGTGGTGAAACATTCTGCACCGGGCGTATTTACCGGTAAACCGGTTGAGTTCGGCGGCTCTTTGGC
GCGTACCGAGGCTACCGGTTACGGCGTGAACCTCGCCGCCGTCCAAGCCTTGGAAAAACTGGGCAAAGACGTGAAGGGTG
CCACTTACGCCATCCAAGGCTTCGGTAATGTCGGTTACCACACAGGTTATTACGCGCATCAATCCGGCGCGAAAGTTGTT
GCGGTTTCTACTGTTGACGTTGCCATTTACAACGAAAACGGCTTGGATATGGAAGCTTTGTTTAAAGAGTTCCAAGAAAA
AGGCTTCATCACCAACGAAGCCGGTTACGGCAAGGAAATTACCAACGCCGAACTTTTGGCTTTGGATGTGGACGTACTCG
CCCCTTGCGCGCTGGAAAATCAACTGACTTCTGAAAACGCCGGTAAAGTCCGCGCGAAAATCGTGGTCGAAGGCGCGAAC
GGCCCGACTACGCCCGAAGCCGACGTTATCCTGCGTCAAAACGGCGTATTGGTCGTGCCCGATATTTTAGCGAACTGCGG
CGGCGTGGTGGTATCTTATTTTGAATGGGTACAAAATCTGCAAGGCTATTATTGGGAGTTTGACGAAGTTCAGGAAAAAG
AAACCGTCGTCCTGCGCCGTGCGTTCCGCGATATATGGAACTTGGCGCAAGAGTATGATGTCGATTTGCGAACCGCGTCT
TACATGATGAGTATCCGCCGTGTTGAAAAAGCGATGAAACTGCGCGGTTGGTATTGA

Upstream 100 bases:

>100_bases
CAAACTCGACGACGACACGGTCAAAACCTTCACGGGCTACCGTTCGCAACACAACAACGCCGTCGGCCCCTATAAAGGCG
GCGTGCGCTTCCATCCCGGA

Downstream 100 bases:

>100_bases
TGTTTGAACAAAAAATGCCGTCTGAAGCCTTCAGACGGCATTTTTGTGCAGGCGGGATTAATGGTGCGAATGGCCGATTT
GGAAGGTTAAAGTCGAGTAG

Product: glutamate dehydrogenase, NAD-specific

Products: NA

Alternate protein names: NAD-GDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNLDEVKALSIWMTIKCCVAGIPYGGGKGGVTLDPRDYSEAELERIARAYSEAISPLIGEKIDIPAPDVNTNGKIMSWMV
DAYENVVKHSAPGVFTGKPVEFGGSLARTEATGYGVNLAAVQALEKLGKDVKGATYAIQGFGNVGYHTGYYAHQSGAKVV
AVSTVDVAIYNENGLDMEALFKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLTSENAGKVRAKIVVEGAN
GPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGYYWEFDEVQEKETVVLRRAFRDIWNLAQEYDVDLRTAS
YMMSIRRVEKAMKLRGWY

Sequences:

>Translated_338_residues
MNLDEVKALSIWMTIKCCVAGIPYGGGKGGVTLDPRDYSEAELERIARAYSEAISPLIGEKIDIPAPDVNTNGKIMSWMV
DAYENVVKHSAPGVFTGKPVEFGGSLARTEATGYGVNLAAVQALEKLGKDVKGATYAIQGFGNVGYHTGYYAHQSGAKVV
AVSTVDVAIYNENGLDMEALFKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLTSENAGKVRAKIVVEGAN
GPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGYYWEFDEVQEKETVVLRRAFRDIWNLAQEYDVDLRTAS
YMMSIRRVEKAMKLRGWY
>Mature_338_residues
MNLDEVKALSIWMTIKCCVAGIPYGGGKGGVTLDPRDYSEAELERIARAYSEAISPLIGEKIDIPAPDVNTNGKIMSWMV
DAYENVVKHSAPGVFTGKPVEFGGSLARTEATGYGVNLAAVQALEKLGKDVKGATYAIQGFGNVGYHTGYYAHQSGAKVV
AVSTVDVAIYNENGLDMEALFKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLTSENAGKVRAKIVVEGAN
GPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGYYWEFDEVQEKETVVLRRAFRDIWNLAQEYDVDLRTAS
YMMSIRRVEKAMKLRGWY

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=396, Percent_Identity=36.6161616161616, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI4885281, Length=396, Percent_Identity=36.1111111111111, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1788059, Length=321, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17544676, Length=292, Percent_Identity=42.1232876712329, Blast_Score=224, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319256, Length=346, Percent_Identity=30.635838150289, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324951, Length=347, Percent_Identity=29.6829971181556, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24649283, Length=294, Percent_Identity=42.5170068027211, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI45553475, Length=396, Percent_Identity=35.3535353535354, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45549226, Length=296, Percent_Identity=40.8783783783784, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24649460, Length=288, Percent_Identity=39.5833333333333, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.2 [H]

Molecular weight: Translated: 36989; Mature: 36989

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDEVKALSIWMTIKCCVAGIPYGGGKGGVTLDPRDYSEAELERIARAYSEAISPLIGE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
KIDIPAPDVNTNGKIMSWMVDAYENVVKHSAPGVFTGKPVEFGGSLARTEATGYGVNLAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHH
VQALEKLGKDVKGATYAIQGFGNVGYHTGYYAHQSGAKVVAVSTVDVAIYNENGLDMEAL
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEEEEEEEECCCCCCHHHH
FKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLTSENAGKVRAKIVVEGAN
HHHHHHCCCEECCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHCCCCCCCEEEEEEEECCC
GPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGYYWEFDEVQEKETVVLRR
CCCCCCCCEEEECCCEEEECHHHCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHH
AFRDIWNLAQEYDVDLRTASYMMSIRRVEKAMKLRGWY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLDEVKALSIWMTIKCCVAGIPYGGGKGGVTLDPRDYSEAELERIARAYSEAISPLIGE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
KIDIPAPDVNTNGKIMSWMVDAYENVVKHSAPGVFTGKPVEFGGSLARTEATGYGVNLAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHH
VQALEKLGKDVKGATYAIQGFGNVGYHTGYYAHQSGAKVVAVSTVDVAIYNENGLDMEAL
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEEEEEEEECCCCCCHHHH
FKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLTSENAGKVRAKIVVEGAN
HHHHHHCCCEECCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHCCCCCCCEEEEEEEECCC
GPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGYYWEFDEVQEKETVVLRR
CCCCCCCCEEEECCCEEEECHHHCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHH
AFRDIWNLAQEYDVDLRTASYMMSIRRVEKAMKLRGWY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1774279 [H]