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The map label for this gene is purE [H]

Identifier: 161870307

GI number: 161870307

Start: 1363478

End: 1363963

Strand: Reverse

Name: purE [H]

Synonym: NMCC_1349

Alternate gene names: 161870307

Gene position: 1363963-1363478 (Counterclockwise)

Preceding gene: 161870308

Following gene: 161870303

Centisome position: 63.34

GC content: 56.17

Gene sequence:

>486_bases
ATGATACAAATCGGCATCATCATGGGCAGCAACAGCGATTGGCCCGTTATGCGGCAGGCAGCGCAGTTTCTTGAAGAATT
CGGCGTAGAATATGAGGCGCGCGTTGTTTCCGCACACCGCACCCCGGATTTGATGTTCCAATACGCCGAAACCGCACGGG
CGCGCGGCATCAAAGCCATCATCGCGGGTGCGGGCGGCGCGGCGCATTTACCCGGTATGGTTGCCGCCAAGACCACCGTC
CCCGTTTTGGGCGTACCCGTCCCCAGCAAATACCTGCGCGGCGAAGATTCGCTTTTATCGATTGTACAAATGCCCAAAGG
CGTACCCGTCGCCACATTCGCCATCGGCGAGGCAGGTGCGGCAAATGCCGCATTGTTCGCCGTTTCCATGCTCGCCAACG
AAAACCCCGAACTGGCGCAAAAACTGGCAGACTTCCGAGCCAAACAAGAACAGACTGTTTTGAATATGGAATTGGAACAG
ATTTAA

Upstream 100 bases:

>100_bases
ACCCGAGCAGCCCGGCGGCAAAACGCGCCGCCGCAGCCGTGCGCAAACGATAGTTTTTCCATTTTTCCGCTTTTTACCCC
ATCCGCACCAAGGAGGATTT

Downstream 100 bases:

>100_bases
AACCCGCCGTCCGCGAATATATAGTGGATTAAATTTAAACCAGTACGGCGTTACCTCGCCTTGCCGTACTATTTGTACTG
TCTTCGGTTTCGTCGCCTTG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAETARARGIKAIIAGAGGAAHLPGMVAAKTTV
PVLGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALFAVSMLANENPELAQKLADFRAKQEQTVLNMELEQ
I

Sequences:

>Translated_161_residues
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAETARARGIKAIIAGAGGAAHLPGMVAAKTTV
PVLGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALFAVSMLANENPELAQKLADFRAKQEQTVLNMELEQ
I
>Mature_161_residues
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAETARARGIKAIIAGAGGAAHLPGMVAAKTTV
PVLGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALFAVSMLANENPELAQKLADFRAKQEQTVLNMELEQ
I

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=152, Percent_Identity=59.8684210526316, Blast_Score=152, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=58.9403973509934, Blast_Score=167, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17167; Mature: 17167

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAETARARGIKAI
CEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMVAAKTTVPVLGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGA
EECCCCCHHCCCCEECCCCCCEEECCCCHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCC
ANAALFAVSMLANENPELAQKLADFRAKQEQTVLNMELEQI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHCC
>Mature Secondary Structure
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAETARARGIKAI
CEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMVAAKTTVPVLGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGA
EECCCCCHHCCCCEECCCCCCEEECCCCHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCC
ANAALFAVSMLANENPELAQKLADFRAKQEQTVLNMELEQI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]