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The map label for this gene is pepQ [H]

Identifier: 161870295

GI number: 161870295

Start: 1347489

End: 1349519

Strand: Direct

Name: pepQ [H]

Synonym: NMCC_1337

Alternate gene names: 161870295

Gene position: 1347489-1349519 (Clockwise)

Preceding gene: 161870292

Following gene: 161870297

Centisome position: 62.57

GC content: 58.89

Gene sequence:

>2031_bases
TTGACTATATTTTCCGTATTACTTCCAAAAAAATGCATAAAACGATATCTTATGCCTAAAATTTTACAACAAACAACCTT
ACATCGCTTTTTTCGCGCAAACACGCACCATCCGATCAGCCCGTCCGTTTTGCAGCAGGCTGGCGATTTGATAAGATGGT
TATGTTTTTCAGACGGCATTTCAGATTTCCGTCCATGCCGTCTGAAGCCGCAAAACCCGATTGGAGGAACTGTTATGAAT
ACCGTATCGAATTACCTGTCCGCATTGCGCGAAGCCATGAAGGCGCAAGGCTTGGATGCACTCGTCATCCCTTCCGCCGA
CCCCCACCTGTCCGAATACCTGCCCGAGCATTGGCAGGCGCGCCGCGAATTATCGGGCTTTACCGGCTCGGTCGGCACGT
TTGTCCTGACCACCGATGAAGCGGGCGTATGGGTGGACAGCCGCTATTGGGAACAAGCCGCCAAGCAGCTTGCGGGCAGC
GGCATCGAACTGCAAAAAAGCGGGCAAGTGCCGCCGTATAACGAATGGCTCGCGGCAAACCTGCCCGAAAACGCCGCCGT
CGGCATCCCTTCCGATATGGTCTCGCTCACCGGCAAACGCACTTTGGCGCAATCCCTGACCGCCAAAAACATCCGCATCG
AACACCCGGACGATCTGCTTGACCAAGTGTGGACAAGCCGTCCCGCTATCCCCGCCGAAACCGTGTTCGTCCACGACCCC
GCCTACGTCTCCGAAACCGCCGCCGAAAAACTCGCCCGCGTGCGCGCCGTGATGGCGGAAAAAGGCGCGGATTACCACTT
GGTTTCCTCGCTCGACGACATCGCCTGGCTGACCAACCTGCGCGGCAGCGACGTGCCTTTCAATCCCGTTTTCGTGTCCT
ATCTATTGATTGGCAAAGACAACGCCGTCCTGTTTACCGACCGATGCCGTCTGAATGCCGAAGCCGCCGCCGCGCTGCAA
ACCGCAGGCATCACGGTCGAGCCTTACGCCCAAGTTGCCGACAAACTCGCGCAAATCGGCGGCGCGTTGCTTATCGAACC
GAACAAAACCGCCGTCAGCACGCTTGTGCGCCTGCCCGAAAGCGTGCGCCTTATCGAGGGAATCAACCCGTCCACGCTGT
TCAAATCCTGCAAATCCGAAGCCGACATCGCCCGCATCCGCGAAGCGATGGAACACGACGGCGCGGCGTTGTGCGGTTTC
TTCGCCGAGTTTGAAGACATCATCGGCAACGGCGGCAGCCTGACCGAAATCGACGTGGACACCATGCTTTATCGCCACCG
CAGCGTGCGCCCAGGCTTCATTTCATTGAGTTTCGACACCATCGCAGGCTTCAACGCCAACGGCGCACTGCCGCATTACA
GCGCAACGCCCGAAAGCCACAGCACCATCAGCGGCAACGGGCTTTTGCTCATCGACTCCGGCGCGCAATACAAAGGCGGC
ACGACCGACATCACCCGCGTCGTCCCTGTCGGCACACCCACCGCCGAACAAAAACGCGACAACACCCTCGTTCTCAAAGC
CCATATCGCGCTTGCCGAAGCCGTGTTCCCCGAAAACATCCCCTCGCCGCTGATTGATGCGATTTGCCGCAAACCCCTGT
GGCAGGCGCAATGCGACTACGGCCACGGCACCGGACACGGCGTAGGCTATTTCCTCAACGTCCACGAAGGCCCGCAGCGC
ATCGCCTTCGCCGCCCCCGCCACGCCCGAAACCGCCATGAAAAAAGGCATGGTTACCTCCATCGAACCCGGACTCTACCG
CCCGGGAAAATGGGGCATCCGCATTGAAAACCTTGCCGCCAACCAAGCCGTCGCCACCCCTCAAGAAACCGAATTCGGCA
GCTTCCTCTGTTTTGAAACCCTGACCCTCTGCCCCATCGATACACGCCTGATGGACACCGCCCTCATGACCGACGGCGAA
ATCGACTGGGTCAACCGCTACCACGCCGAAGTCCGCCGCCGCCTCGAGCCGCTGACCGAAGGCGCGGCAAAAGCGTGGCT
GATCAAACGCACCGAACCGCTGGCGCGTTAA

Upstream 100 bases:

>100_bases
AAACAGGATACCGCCCGGTAGGGAAATTTTGATGAAAGCGCGTATTGTAACGTAATCCAAATACCTGCCAACACACACTA
TTAGAACTTCATGCTCAAAC

Downstream 100 bases:

>100_bases
ACAGCACGGCGCAAAAAATGCCGTCTGAAAGCCCTTCAGACGGCATTGGTTTCCCAAAACATCCCGCACCGTTTTCATCT
TGCCGCAAGCAAATATAGTG

Product: aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MTIFSVLLPKKCIKRYLMPKILQQTTLHRFFRANTHHPISPSVLQQAGDLIRWLCFSDGISDFRPCRLKPQNPIGGTVMN
TVSNYLSALREAMKAQGLDALVIPSADPHLSEYLPEHWQARRELSGFTGSVGTFVLTTDEAGVWVDSRYWEQAAKQLAGS
GIELQKSGQVPPYNEWLAANLPENAAVGIPSDMVSLTGKRTLAQSLTAKNIRIEHPDDLLDQVWTSRPAIPAETVFVHDP
AYVSETAAEKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKDNAVLFTDRCRLNAEAAAALQ
TAGITVEPYAQVADKLAQIGGALLIEPNKTAVSTLVRLPESVRLIEGINPSTLFKSCKSEADIARIREAMEHDGAALCGF
FAEFEDIIGNGGSLTEIDVDTMLYRHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGG
TTDITRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYGHGTGHGVGYFLNVHEGPQR
IAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIENLAANQAVATPQETEFGSFLCFETLTLCPIDTRLMDTALMTDGE
IDWVNRYHAEVRRRLEPLTEGAAKAWLIKRTEPLAR

Sequences:

>Translated_676_residues
MTIFSVLLPKKCIKRYLMPKILQQTTLHRFFRANTHHPISPSVLQQAGDLIRWLCFSDGISDFRPCRLKPQNPIGGTVMN
TVSNYLSALREAMKAQGLDALVIPSADPHLSEYLPEHWQARRELSGFTGSVGTFVLTTDEAGVWVDSRYWEQAAKQLAGS
GIELQKSGQVPPYNEWLAANLPENAAVGIPSDMVSLTGKRTLAQSLTAKNIRIEHPDDLLDQVWTSRPAIPAETVFVHDP
AYVSETAAEKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKDNAVLFTDRCRLNAEAAAALQ
TAGITVEPYAQVADKLAQIGGALLIEPNKTAVSTLVRLPESVRLIEGINPSTLFKSCKSEADIARIREAMEHDGAALCGF
FAEFEDIIGNGGSLTEIDVDTMLYRHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGG
TTDITRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYGHGTGHGVGYFLNVHEGPQR
IAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIENLAANQAVATPQETEFGSFLCFETLTLCPIDTRLMDTALMTDGE
IDWVNRYHAEVRRRLEPLTEGAAKAWLIKRTEPLAR
>Mature_675_residues
TIFSVLLPKKCIKRYLMPKILQQTTLHRFFRANTHHPISPSVLQQAGDLIRWLCFSDGISDFRPCRLKPQNPIGGTVMNT
VSNYLSALREAMKAQGLDALVIPSADPHLSEYLPEHWQARRELSGFTGSVGTFVLTTDEAGVWVDSRYWEQAAKQLAGSG
IELQKSGQVPPYNEWLAANLPENAAVGIPSDMVSLTGKRTLAQSLTAKNIRIEHPDDLLDQVWTSRPAIPAETVFVHDPA
YVSETAAEKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKDNAVLFTDRCRLNAEAAAALQT
AGITVEPYAQVADKLAQIGGALLIEPNKTAVSTLVRLPESVRLIEGINPSTLFKSCKSEADIARIREAMEHDGAALCGFF
AEFEDIIGNGGSLTEIDVDTMLYRHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGGT
TDITRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDYGHGTGHGVGYFLNVHEGPQRI
AFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIENLAANQAVATPQETEFGSFLCFETLTLCPIDTRLMDTALMTDGEI
DWVNRYHAEVRRRLEPLTEGAAKAWLIKRTEPLAR

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=619, Percent_Identity=37.4798061389338, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI93141226, Length=635, Percent_Identity=34.3307086614173, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI264681565, Length=619, Percent_Identity=35.3796445880452, Blast_Score=342, Evalue=9e-94,
Organism=Escherichia coli, GI1788728, Length=182, Percent_Identity=34.6153846153846, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=33.3333333333333, Blast_Score=333, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI25149105, Length=593, Percent_Identity=29.1736930860034, Blast_Score=258, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322999, Length=659, Percent_Identity=30.804248861912, Blast_Score=295, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17137632, Length=617, Percent_Identity=35.4943273905997, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI161078230, Length=623, Percent_Identity=27.6083467094703, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI21357287, Length=623, Percent_Identity=27.6083467094703, Blast_Score=245, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 73947; Mature: 73816

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIFSVLLPKKCIKRYLMPKILQQTTLHRFFRANTHHPISPSVLQQAGDLIRWLCFSDGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SDFRPCRLKPQNPIGGTVMNTVSNYLSALREAMKAQGLDALVIPSADPHLSEYLPEHWQA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCHHHHHH
RRELSGFTGSVGTFVLTTDEAGVWVDSRYWEQAAKQLAGSGIELQKSGQVPPYNEWLAAN
HHHHCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHCCC
LPENAAVGIPSDMVSLTGKRTLAQSLTAKNIRIEHPDDLLDQVWTSRPAIPAETVFVHDP
CCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEECCHHHHHHHHHCCCCCCCCEEEEECC
AYVSETAAEKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKD
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECC
NAVLFTDRCRLNAEAAAALQTAGITVEPYAQVADKLAQIGGALLIEPNKTAVSTLVRLPE
CEEEEECCCCCCHHHHHHHHHCCCEECHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCH
SVRLIEGINPSTLFKSCKSEADIARIREAMEHDGAALCGFFAEFEDIIGNGGSLTEIDVD
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEHH
TMLYRHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGG
HHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCCCCCCC
TTDITRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDY
CCCCEEEEECCCCCHHHCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCC
GHGTGHGVGYFLNVHEGPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIENLAA
CCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHCCCCEECCCCCCCCCCCCEEEECCCC
NQAVATPQETEFGSFLCFETLTLCPIDTRLMDTALMTDGEIDWVNRYHAEVRRRLEPLTE
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GAAKAWLIKRTEPLAR
HHHHEEEEECCCCCCC
>Mature Secondary Structure 
TIFSVLLPKKCIKRYLMPKILQQTTLHRFFRANTHHPISPSVLQQAGDLIRWLCFSDGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
SDFRPCRLKPQNPIGGTVMNTVSNYLSALREAMKAQGLDALVIPSADPHLSEYLPEHWQA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCHHHHHH
RRELSGFTGSVGTFVLTTDEAGVWVDSRYWEQAAKQLAGSGIELQKSGQVPPYNEWLAAN
HHHHCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHCCC
LPENAAVGIPSDMVSLTGKRTLAQSLTAKNIRIEHPDDLLDQVWTSRPAIPAETVFVHDP
CCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEECCHHHHHHHHHCCCCCCCCEEEEECC
AYVSETAAEKLARVRAVMAEKGADYHLVSSLDDIAWLTNLRGSDVPFNPVFVSYLLIGKD
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECC
NAVLFTDRCRLNAEAAAALQTAGITVEPYAQVADKLAQIGGALLIEPNKTAVSTLVRLPE
CEEEEECCCCCCHHHHHHHHHCCCEECHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCH
SVRLIEGINPSTLFKSCKSEADIARIREAMEHDGAALCGFFAEFEDIIGNGGSLTEIDVD
HHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEHH
TMLYRHRSVRPGFISLSFDTIAGFNANGALPHYSATPESHSTISGNGLLLIDSGAQYKGG
HHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCCCCCCC
TTDITRVVPVGTPTAEQKRDNTLVLKAHIALAEAVFPENIPSPLIDAICRKPLWQAQCDY
CCCCEEEEECCCCCHHHCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCC
GHGTGHGVGYFLNVHEGPQRIAFAAPATPETAMKKGMVTSIEPGLYRPGKWGIRIENLAA
CCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHCCCCEECCCCCCCCCCCCEEEECCCC
NQAVATPQETEFGSFLCFETLTLCPIDTRLMDTALMTDGEIDWVNRYHAEVRRRLEPLTE
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GAAKAWLIKRTEPLAR
HHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]