Click here to switch to the map view.

The map label for this gene is betT [C]

Identifier: 161870149

GI number: 161870149

Start: 1176335

End: 1178362

Strand: Reverse

Name: betT [C]

Synonym: NMCC_1188

Alternate gene names: 161870149

Gene position: 1178362-1176335 (Counterclockwise)

Preceding gene: 161870150

Following gene: 161870147

Centisome position: 54.72

GC content: 51.53

Gene sequence:

>2028_bases
TTGTCCCTGTCTGAATTTATAGAACGCCGAACGTCATTTAATCCGATGGTTATTTTGACGACTTTGTTTTTTGTGTGTGT
TTTGGTGGTATTGGTTTTAACCGTGCCGGATCAGGCGCAGATGTGGCTCGATCGGGCAAAAGAAGTCATTTTTACCGAGT
TCAGCTGGTTTTATGTTTTAACGTTTTCCATTTTTCTGGGTTTCCTGCTGATACTCTCGGTCAGCAGTTTGGGAAACATC
AGGCTCGGACGGGATGAAGATGTGCCGGAATTCGGCTTCCTGTCGTGGCTGGCGATGCTGTTTGCGGCCGGGATGGGCGT
GGGTCTGATGTTTTTCGGCGTGGCAGAGCCGTTGATGCATTATTTTTCGGACATTACGGCCGGCACGCCGGAACACAGGC
AGCAGCAGGCATTGCTGCACACGGTGTTCCATTGGGGCGTTCACGCTTGGTCGGTGTACGGTACGATTGCATTGGCTTTG
GCTTATTTCGGTTTCCGCTACAAGCTGCCGCTTGCCCTGCGTTCTTGTTTTTACCCCCTGTTGAAAGAAAAAATTTCCGG
AAGGTTCGGCGATGCCATTGATATTATGGCGTTGCTTGCTACTTTTTTCGGCATCATCACCACATTGGGGTTCGGGGCTT
CGCAACTGGGCGCCGGATTGCAGGAAATGGGCTGGATTGCCGAAAACAGCTTCAGCGTGCAGGTTTTGATTATCGCCGCC
GTCATGTCCCTCGCCGTCGTTTCGGCAATATCCGGCGTGGGGAAGGGCGTGAAGGTGTTGAGCGAGTTGAACCTGAGCCT
TGCGTTTTTGCTGCTGTTTTTTGTTTTGGCGGCGGGTCCCACTGTTTACCTGTTGTCGGCATTCGGCGACAACATAGGGA
ACTACCTCGGAAATCTGGTGCGCCTCAGTTTTAAAACTTATGCGTACGAACGGGAACACAAGCCGTGGTTTGAATCTTGG
ACGGTGCTTTATTGGGCGTGGTGGTGTTCTTGGGCGCCGTTTGTGGGTTTGTTTATCGCGCGCATTTCAAAGGGGCGCAC
CATCCGCGAGTTTGTCTTCGGGGTTTTGCTCATCCCCGGCCTGTTCGGCGTTTTGTGGTTTACCGTCTTCGGCAATACGG
CGATTTGGCTGAATGACGGGGTTGCGGGGGGAGTGCTCGAAAAAATGACCTCCTCTCCGGAAACGCTGCTTTTTAAATTC
TTTAATTACCTCCCTCTGCCCGAACTGACGAGCATCGTCAGCCTGCTGGTCATTTCTCTGTTTTTTGTAACTTCTGCCGA
TTCCGGGATTTATGTCCTGAACAATATTACCTCTCGGGACAAAGGCTTGAGCGCGCCACGGTGGCAGGCGGTTATGTGGG
GCGTGCTGATGTCTGCCGTTGCCGTTTTGCTGATGCGCTCGGGCGGACTCGGCAACCTGCAGTCTATGACCCTGATTGTT
TCCCTGCCGTTTGCCCTGCTGATGCTGATAATGTGTTTCAGCCTGTGGAAAGGATTGAGTGCGGATAAGAAATATTTTGA
GACCCGGGTTAACCCTACCAGTGTATTTTGGACGGGCGGCAAGTGGAAAGAACGGCTGGTGCAGATAATGAGCCAGACGC
AGGAGCAGGATATTTTAAAATTCCTCAAACATACCGCATCGCCCGCTATGCACGAGTTGCAACGGGAGCTTTCGGAAGAA
TACGGCTTGAGCGTCCGGGTCGATAAGATGTTTCATCAGGACGAGCCCGCAATCGAGTTCGTCATTCGGAAAGAGACGAT
GCGCGATTTTATGTACGGGATTAAGTCTGTCGGGCAGGATGTATCCGACCAGTTGATTAACGACGGCAAGCTGCCGCATA
TCCGGCACCAGACAACTTACAAACCCTACGCTTATTTTTTCGACGGGCGCGTCGGGTACGATGTGCAGTATATGAACAAG
GACGAGCTGATTGCCGACATTTTGAAAAACTACGAACGTTATTTGATGTTGTTGGATGATGTCGGTCAGGAACTGATGGC
GCACGAGCAGGTGGAATTGGCAGAGTAA

Upstream 100 bases:

>100_bases
TGTGCATTTCGTCATCCGGAAGCCGGTATTTTACCGGCAGGTTTTGACCGCTTTGCCCGATGACCGGGTTTGTCTGTTTT
TAACAAAGGAGTGAGAAGGT

Downstream 100 bases:

>100_bases
ATATCCTCGCTCCGGCGTTTGCCAAAAAAATGCGGTGAAGCAGATTCACCGCATTTTTTTTGCCGGACGGGGCTTCGGAC
GGCACGGCGTTCATTTGTTT

Product: high-affinity choline transport protein

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MSLSEFIERRTSFNPMVILTTLFFVCVLVVLVLTVPDQAQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVSSLGNI
RLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQQALLHTVFHWGVHAWSVYGTIALAL
AYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDIMALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFSVQVLIIAA
VMSLAVVSAISGVGKGVKVLSELNLSLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKPWFESW
TVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAIWLNDGVAGGVLEKMTSSPETLLFKF
FNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNNITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIV
SLPFALLMLIMCFSLWKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKHTASPAMHELQRELSEE
YGLSVRVDKMFHQDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIRHQTTYKPYAYFFDGRVGYDVQYMNK
DELIADILKNYERYLMLLDDVGQELMAHEQVELAE

Sequences:

>Translated_675_residues
MSLSEFIERRTSFNPMVILTTLFFVCVLVVLVLTVPDQAQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVSSLGNI
RLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQQALLHTVFHWGVHAWSVYGTIALAL
AYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDIMALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFSVQVLIIAA
VMSLAVVSAISGVGKGVKVLSELNLSLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKPWFESW
TVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAIWLNDGVAGGVLEKMTSSPETLLFKF
FNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNNITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIV
SLPFALLMLIMCFSLWKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKHTASPAMHELQRELSEE
YGLSVRVDKMFHQDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIRHQTTYKPYAYFFDGRVGYDVQYMNK
DELIADILKNYERYLMLLDDVGQELMAHEQVELAE
>Mature_674_residues
SLSEFIERRTSFNPMVILTTLFFVCVLVVLVLTVPDQAQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVSSLGNIR
LGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQQALLHTVFHWGVHAWSVYGTIALALA
YFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDIMALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFSVQVLIIAAV
MSLAVVSAISGVGKGVKVLSELNLSLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKPWFESWT
VLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAIWLNDGVAGGVLEKMTSSPETLLFKFF
NYLPLPELTSIVSLLVISLFFVTSADSGIYVLNNITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIVS
LPFALLMLIMCFSLWKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKHTASPAMHELQRELSEEY
GLSVRVDKMFHQDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIRHQTTYKPYAYFFDGRVGYDVQYMNKD
ELIADILKNYERYLMLLDDVGQELMAHEQVELAE

Specific function: High-Affinity Uptake Of Choline Driven By A Proton- Motive Force. [C]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=662, Percent_Identity=34.2900302114804, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788102, Length=436, Percent_Identity=29.5871559633028, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1786224, Length=519, Percent_Identity=26.7822736030828, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 76235; Mature: 76104

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLSEFIERRTSFNPMVILTTLFFVCVLVVLVLTVPDQAQMWLDRAKEVIFTEFSWFYVL
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]