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The map label for this gene is ppiA [H]

Identifier: 161870135

GI number: 161870135

Start: 1163224

End: 1163781

Strand: Reverse

Name: ppiA [H]

Synonym: NMCC_1174

Alternate gene names: 161870135

Gene position: 1163781-1163224 (Counterclockwise)

Preceding gene: 161870136

Following gene: 161870134

Centisome position: 54.04

GC content: 51.97

Gene sequence:

>558_bases
ATGAAACCCAAATTCAAAACCGTTTTAACCGCGCTGCTTTTGGCGGTTTCCCTGCCGTCTATGGCGGCAACCCATGTTTT
GATGGAAACCGATATGGGCAATATCCGTTTGGTTTTGGACGAATCCAAAGCACCCAAAACCGTTGCCAATTTCGTGCGCT
ATGCCCGAAAAGGCTTTTACGACAATACGATTTTTCACCGCGTCATCGGCGGCTTCGTTATCCAAGGCGGCGGATTGACC
GAGGACTTGGCACAAAAGGCAAGCGATAAGGCCGTTGCCAACGAATCCGGCAACGGCTTGAAAAACACTGTCGGCACCAT
CGCCATGGCGCGGACGACAGACCCCGATTCCGCCACCAGCCAATTCTTTATCAATCTGGCGGACAATGATTCACTCAACT
ACAAAAACGGACAATACGGCTATACCGTTTTCGGCAGGGTCGAAAGCGGAATGGACACCGTTTCCAAAATCGCCCGCGTC
AAAACCGCCACGCGCGGCTTTTATCAAAACGTACCCGTACAGCCCGTCAAAATCCGTCGCGTTGTTGTCGGGCAGTAA

Upstream 100 bases:

>100_bases
TTAATCGAACAAAAGCTCAAAGACGCATTGGAATAGCGTTCACGCGCCTTCAGACGGCATATGAAATGAAAATGCCGTCT
GAAGGTCTGAGGAGGACGGG

Downstream 100 bases:

>100_bases
CACGCAGACAGACGTTCAGACGGCGTCGCCCGTTTCCCAAAAAACGCCGTTTAAATTAAAAAAATATTTTAAAACAGACA
GTTGATATTGACAAATTCAA

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFYDNTIFHRVIGGFVIQGGGLT
EDLAQKASDKAVANESGNGLKNTVGTIAMARTTDPDSATSQFFINLADNDSLNYKNGQYGYTVFGRVESGMDTVSKIARV
KTATRGFYQNVPVQPVKIRRVVVGQ

Sequences:

>Translated_185_residues
MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFYDNTIFHRVIGGFVIQGGGLT
EDLAQKASDKAVANESGNGLKNTVGTIAMARTTDPDSATSQFFINLADNDSLNYKNGQYGYTVFGRVESGMDTVSKIARV
KTATRGFYQNVPVQPVKIRRVVVGQ
>Mature_185_residues
MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFYDNTIFHRVIGGFVIQGGGLT
EDLAQKASDKAVANESGNGLKNTVGTIAMARTTDPDSATSQFFINLADNDSLNYKNGQYGYTVFGRVESGMDTVSKIARV
KTATRGFYQNVPVQPVKIRRVVVGQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=169, Percent_Identity=39.6449704142012, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI64276486, Length=161, Percent_Identity=35.4037267080745, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI22547215, Length=141, Percent_Identity=36.8794326241135, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI19557636, Length=161, Percent_Identity=29.8136645962733, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI22547212, Length=141, Percent_Identity=36.8794326241135, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI7657473, Length=141, Percent_Identity=36.8794326241135, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789763, Length=182, Percent_Identity=55.4945054945055, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=51.5337423312883, Blast_Score=166, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=40.2777777777778, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=175, Percent_Identity=31.4285714285714, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=161, Percent_Identity=32.2981366459627, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=161, Percent_Identity=32.2981366459627, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=32.8671328671329, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=38.5093167701863, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922376, Length=144, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922912, Length=139, Percent_Identity=36.6906474820144, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136360, Length=194, Percent_Identity=31.9587628865979, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357249, Length=125, Percent_Identity=34.4, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20111; Mature: 20111

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFY
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
DNTIFHRVIGGFVIQGGGLTEDLAQKASDKAVANESGNGLKNTVGTIAMARTTDPDSATS
CHHHHHHHHHHEEEECCCCCHHHHHHHCCHHHCCCCCCCHHHHHHHEEEEECCCCCCCCC
QFFINLADNDSLNYKNGQYGYTVFGRVESGMDTVSKIARVKTATRGFYQNVPVQPVKIRR
EEEEEECCCCCCCCCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VVVGQ
EECCC
>Mature Secondary Structure
MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFY
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
DNTIFHRVIGGFVIQGGGLTEDLAQKASDKAVANESGNGLKNTVGTIAMARTTDPDSATS
CHHHHHHHHHHEEEECCCCCHHHHHHHCCHHHCCCCCCCHHHHHHHEEEEECCCCCCCCC
QFFINLADNDSLNYKNGQYGYTVFGRVESGMDTVSKIARVKTATRGFYQNVPVQPVKIRR
EEEEEECCCCCCCCCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VVVGQ
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]