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The map label for this gene is ribA [H]

Identifier: 161870098

GI number: 161870098

Start: 1121714

End: 1122307

Strand: Direct

Name: ribA [H]

Synonym: NMCC_1137

Alternate gene names: 161870098

Gene position: 1121714-1122307 (Clockwise)

Preceding gene: 161870097

Following gene: 161870099

Centisome position: 52.09

GC content: 54.71

Gene sequence:

>594_bases
ATGTCTGAAATGTTGAACCATGTGGCATCCTGCCGCCTGCCGACCGAATGGGGCGTATTTACGATGCACGGCTTTGAAGA
GGCAAACGGGCAGGAACACGTCGCGCTGACCGTCGGTAATTTTTCAGACGGCAATCCGGTTCTGACGCGCATCCACTCCG
AATGCCTGACGGGCGATGCGCTGTTCTCGAGAAAATGCGACTGCGGACCTCAACTTGAAGCGGCCATGAGGGCGGTACAG
ACAGAGGGGCGCGGCATCATCGTCTATCTGCGTCAGGAAGGACGCGGCATCGGGCTGATTAACAAAATCCGCGCCTATCA
TCTGCAAGACCAAGGTATGGATACGGTTGAAGCCAATTTGGCACTCGGGCTGCCCGTCGATGCCCGCGATTTCCGTTTGG
CGCAATCTATCTACGAATATCTGGGCATCCGCTCGGTCAAACTGCTGACCAACAACCCCGAAAAAATCCAAACCCTGAAA
GATGCGGGGATTAACGTGGTCGAACGCATCCCCCTGCACGTCGGGGAAAACCTTGAAAACAAACGCTACCTCCAAACCAA
AGCAGACAAGCTGGGACATCTGATGTCGGAATAA

Upstream 100 bases:

>100_bases
GGTACGGCAGCACAGGTGGAATGGGTGGCTCTTGCCTTGGCTTTGTCCGAACCTTTGAAACTGCTGTTGGGTATGTCTGC
CGGAAAAGATGGGAGTGAAG

Downstream 100 bases:

>100_bases
GGCAAAGTTGCAGGGAACGGGCATCCTGCGCCGCCTTTCGGGAAACAGGTTTCCATACCTTGATAAAGCAATAAGTTTTA
TAGTGGATGCAAACGCATTG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDALFSRKCDCGPQLEAAMRAVQ
TEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLK
DAGINVVERIPLHVGENLENKRYLQTKADKLGHLMSE

Sequences:

>Translated_197_residues
MSEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDALFSRKCDCGPQLEAAMRAVQ
TEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLK
DAGINVVERIPLHVGENLENKRYLQTKADKLGHLMSE
>Mature_196_residues
SEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDALFSRKCDCGPQLEAAMRAVQT
EGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKD
AGINVVERIPLHVGENLENKRYLQTKADKLGHLMSE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=60.8247422680412, Blast_Score=245, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319438, Length=194, Percent_Identity=45.360824742268, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21930; Mature: 21799

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDA
CHHHHHHHHHCCCCCCCCEEEECCCHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHH
LFSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANL
HHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCE
ALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLEN
EECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCHHHHCCHHCCCCCCC
KRYLQTKADKLGHLMSE
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDA
HHHHHHHHHCCCCCCCCEEEECCCHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHH
LFSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANL
HHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCE
ALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLEN
EECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCHHHHCCHHCCCCCCC
KRYLQTKADKLGHLMSE
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA