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The map label for this gene is lon [H]

Identifier: 161870074

GI number: 161870074

Start: 1097005

End: 1099455

Strand: Reverse

Name: lon [H]

Synonym: NMCC_1112

Alternate gene names: 161870074

Gene position: 1099455-1097005 (Counterclockwise)

Preceding gene: 161870076

Following gene: 161870073

Centisome position: 51.06

GC content: 53.61

Gene sequence:

>2451_bases
ATGACACAAAAAGAAAAGCATTTTGAGGAATATGCCGCCTTGGCAACCCTTCCTTTGCGGGATGTCGTCGTTTACCCGCA
TATGGTTCTGCCGCTGTTTGTCGGCAGGCCGAAATCCATCGCCGCACTGGAAAACGCCATTACCCGCGAGGAGCCGGTTT
TCCTGTTGGCGCAAACCGATGCGGCGGTAGAAGAACCGGTTGCCGCCGACCTGTATCAGACCGGTACGGTCGCACAAGTC
CTGCAAGTGTTGAAACTACCCGACGGCACGGTAAAAGTATTGGTCGAAGGGCTGTATCGCGGACGTGTTCTGACCATTGA
AGACACGGGCGGTCTGTTCGTTTCCCATATAGAGACGGTCGTGGAAGAAGACACGGGCGGCAATACCGACCTCGAAGCCG
TGCGCCGCACCCTGTTGGCGCAGTTTGAACAATACGCCAAACTCAATAAAAAAATCCCCGCCGAAATTATCGGCAGCATT
AACGGCATTGCCGAAAACAGCCGGCTAACCGATACGGTCGCAGCGCATTTGCAGTTGAAACTGGCGCAACGCCAACAGAT
TTTGGAAATTCCCGAAATCGGCAAACGGATGGAATTCCTGCTGGCACAGCTGGAATCCGAACTCGACATTATGCAGGCCG
AAAAACGCATACGCGGACGCGTCAAACGCCAAATGGAAAAATCCCAGCGCGAATATTATCTGAACGAACAGATTAAAGCG
ATACACAAAGAATTGGGCGAAGAAGACGAAAACGGCGAACTGGATGCCTTGGAAGCAGGCATCAAAAAGGCGGGGATGAG
CAAAGAAGCGGAAGAAAAATGCCTGTCCGAACTGAAAAAACTCAAAATGATGCCGCCGATGTCTGCCGAATCCACCGTCG
TACGCAACTACATCGACACCCTGCTCGAACTGCCGTGGAAGAAAAAATCCCGCGTCAGCAAAGACATCGCCAAAGCCGGA
CTGGTGCTGGATGCCGACCACTACGGCATGGAAAAAGTCAAAGAACGGATTTTGGAATACCTCGCCGTCCAAAAACGTAT
GGACAAACTCAAAGGCCCGATTCTGTGCTTGGTCGGCCCTCCGGGCGTGGGCAAAACCTCTTTGGGCGAATCCATCGCCA
AAGCAACAGGGCGGAAATATGTCCGCATGGCTTTGGGCGGCGTGCGCGACGAAAGCGAAATCCGGGGACACCGCCGCACC
TATATCGGCTCCATGCCTGGTAAGATTCTGCAGAATATGGCAAAAGCCGGCGTAAAAAACCCATTGTTCCTGCTCGACGA
AATCGACAAATTGGGTAGCGACTTCCGGGGCGATCCCGCCAGCGCGTTGCTCGAAGTGCTTGATCCCGAGCAAAACAACA
AGTTCGCCGATCATTATGCGGAAGTGGATTACGATTTGAGTGATGTGATGTTTATCGCCACATCCAATAGTCTGAATATC
CCGACACCGCTGCTCGACCGTATGGAAATCATCCGTCTGTCCGGCTATACCGAAGACGAAAAAATCAATATCGCGATGCA
GTACCTCGTGCCGAAGCAAATGAAGCGCAACGGCGTAAAAGAAGGGGAATTGGCAATCGAAGAAAGCGCGGTGCGCGATA
TTATCCGTTACTACACCCGCGAGGCGGGCGTGCGTTCGCTCGACCGCGAGATTGCCAAAATCTGCCGCAAGGTGGTGATG
CAGATTACCTTGGACGAAGACTCAAAAACCAAAAAAACCGGAAAAGCCAAGCCCAGGGCGGTTAAAGTAAATGAGAAAAA
TCTGCACGACTATTTGGGTGTGCGCCGCTTCGATTACGGCGTTGCCGAAAGCGAAAACCGTATCGGACAAGTAACCGGTC
TGGCGTGGACAGAAGTCGGCGGCGAACTGCTGACCGTCGAAGCCGCAGCATTGCCGGGTAAGGGCGTGATTCAGTGCACC
GGCCAGTTGGGCGATGTGATGAAGGAATCCGTGTCCGCAGCATGGTCGGTTGTCCGCTCCCGCGCGGAATCAGTGGGCTT
GGCTCCTGATTTTTACGAGAAAAAAGACATCCATGTCCATGTTCCCGAAGGTGCGACGCCGAAAGACGGTCCGAGTGCGG
GCATTGCCATGACTTTGGCGATGGTGTCTGCATTCACCAAAATCCCGGTGCGCGCCGATGTAGCGATGACGGGCGAAATT
ACCCTGCGCGGCGAAGTCCTGCCGATTGGCGGTCTGAAGGAAAAACTGTTGGCTGCGCTTCGCGGCGGCATCAAACACGT
TTTAATTCCAAAAGACAACCTCAAAGACTTGGAAGAAATCCCTGAAAACGTGAAAACCGGCCTGACCATCCATCCGGTCA
AATGGATAGACGAGGTATTGGCTCTGGGTTTGGAAAGCCAGCCTGAGCCTTGGGCAGAACCTTCTGGCGCGGAAGCGGCG
GCGGAATCCGCTTCAAAACCGAAACCCCGCAGCAGGGCAACCAAACATTGA

Upstream 100 bases:

>100_bases
TCGCATCAAACTCCATAAATAAACCACATATGCTTGAAATAATACCTTCAACCCCAATGTACGCGAAAATCGGCAATCTG
TCAGACACAAGAGAGTACCT

Downstream 100 bases:

>100_bases
AACGCAGGAAATGTGTTGTAAAAATGCGGTTTCGTCCTGAAAGCCTGTCAAATAGGGTGATTCCGTATTTTTTGCTTGAC
ACGGCAATTTCAGAATTGCT

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MTQKEKHFEEYAALATLPLRDVVVYPHMVLPLFVGRPKSIAALENAITREEPVFLLAQTDAAVEEPVAADLYQTGTVAQV
LQVLKLPDGTVKVLVEGLYRGRVLTIEDTGGLFVSHIETVVEEDTGGNTDLEAVRRTLLAQFEQYAKLNKKIPAEIIGSI
NGIAENSRLTDTVAAHLQLKLAQRQQILEIPEIGKRMEFLLAQLESELDIMQAEKRIRGRVKRQMEKSQREYYLNEQIKA
IHKELGEEDENGELDALEAGIKKAGMSKEAEEKCLSELKKLKMMPPMSAESTVVRNYIDTLLELPWKKKSRVSKDIAKAG
LVLDADHYGMEKVKERILEYLAVQKRMDKLKGPILCLVGPPGVGKTSLGESIAKATGRKYVRMALGGVRDESEIRGHRRT
YIGSMPGKILQNMAKAGVKNPLFLLDEIDKLGSDFRGDPASALLEVLDPEQNNKFADHYAEVDYDLSDVMFIATSNSLNI
PTPLLDRMEIIRLSGYTEDEKINIAMQYLVPKQMKRNGVKEGELAIEESAVRDIIRYYTREAGVRSLDREIAKICRKVVM
QITLDEDSKTKKTGKAKPRAVKVNEKNLHDYLGVRRFDYGVAESENRIGQVTGLAWTEVGGELLTVEAAALPGKGVIQCT
GQLGDVMKESVSAAWSVVRSRAESVGLAPDFYEKKDIHVHVPEGATPKDGPSAGIAMTLAMVSAFTKIPVRADVAMTGEI
TLRGEVLPIGGLKEKLLAALRGGIKHVLIPKDNLKDLEEIPENVKTGLTIHPVKWIDEVLALGLESQPEPWAEPSGAEAA
AESASKPKPRSRATKH

Sequences:

>Translated_816_residues
MTQKEKHFEEYAALATLPLRDVVVYPHMVLPLFVGRPKSIAALENAITREEPVFLLAQTDAAVEEPVAADLYQTGTVAQV
LQVLKLPDGTVKVLVEGLYRGRVLTIEDTGGLFVSHIETVVEEDTGGNTDLEAVRRTLLAQFEQYAKLNKKIPAEIIGSI
NGIAENSRLTDTVAAHLQLKLAQRQQILEIPEIGKRMEFLLAQLESELDIMQAEKRIRGRVKRQMEKSQREYYLNEQIKA
IHKELGEEDENGELDALEAGIKKAGMSKEAEEKCLSELKKLKMMPPMSAESTVVRNYIDTLLELPWKKKSRVSKDIAKAG
LVLDADHYGMEKVKERILEYLAVQKRMDKLKGPILCLVGPPGVGKTSLGESIAKATGRKYVRMALGGVRDESEIRGHRRT
YIGSMPGKILQNMAKAGVKNPLFLLDEIDKLGSDFRGDPASALLEVLDPEQNNKFADHYAEVDYDLSDVMFIATSNSLNI
PTPLLDRMEIIRLSGYTEDEKINIAMQYLVPKQMKRNGVKEGELAIEESAVRDIIRYYTREAGVRSLDREIAKICRKVVM
QITLDEDSKTKKTGKAKPRAVKVNEKNLHDYLGVRRFDYGVAESENRIGQVTGLAWTEVGGELLTVEAAALPGKGVIQCT
GQLGDVMKESVSAAWSVVRSRAESVGLAPDFYEKKDIHVHVPEGATPKDGPSAGIAMTLAMVSAFTKIPVRADVAMTGEI
TLRGEVLPIGGLKEKLLAALRGGIKHVLIPKDNLKDLEEIPENVKTGLTIHPVKWIDEVLALGLESQPEPWAEPSGAEAA
AESASKPKPRSRATKH
>Mature_815_residues
TQKEKHFEEYAALATLPLRDVVVYPHMVLPLFVGRPKSIAALENAITREEPVFLLAQTDAAVEEPVAADLYQTGTVAQVL
QVLKLPDGTVKVLVEGLYRGRVLTIEDTGGLFVSHIETVVEEDTGGNTDLEAVRRTLLAQFEQYAKLNKKIPAEIIGSIN
GIAENSRLTDTVAAHLQLKLAQRQQILEIPEIGKRMEFLLAQLESELDIMQAEKRIRGRVKRQMEKSQREYYLNEQIKAI
HKELGEEDENGELDALEAGIKKAGMSKEAEEKCLSELKKLKMMPPMSAESTVVRNYIDTLLELPWKKKSRVSKDIAKAGL
VLDADHYGMEKVKERILEYLAVQKRMDKLKGPILCLVGPPGVGKTSLGESIAKATGRKYVRMALGGVRDESEIRGHRRTY
IGSMPGKILQNMAKAGVKNPLFLLDEIDKLGSDFRGDPASALLEVLDPEQNNKFADHYAEVDYDLSDVMFIATSNSLNIP
TPLLDRMEIIRLSGYTEDEKINIAMQYLVPKQMKRNGVKEGELAIEESAVRDIIRYYTREAGVRSLDREIAKICRKVVMQ
ITLDEDSKTKKTGKAKPRAVKVNEKNLHDYLGVRRFDYGVAESENRIGQVTGLAWTEVGGELLTVEAAALPGKGVIQCTG
QLGDVMKESVSAAWSVVRSRAESVGLAPDFYEKKDIHVHVPEGATPKDGPSAGIAMTLAMVSAFTKIPVRADVAMTGEIT
LRGEVLPIGGLKEKLLAALRGGIKHVLIPKDNLKDLEEIPENVKTGLTIHPVKWIDEVLALGLESQPEPWAEPSGAEAAA
ESASKPKPRSRATKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=761, Percent_Identity=40.473061760841, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI21396489, Length=686, Percent_Identity=39.5043731778426, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1786643, Length=780, Percent_Identity=66.1538461538461, Blast_Score=1045, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=709, Percent_Identity=38.9280677009873, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=39.8897058823529, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=711, Percent_Identity=40.5063291139241, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24666867, Length=652, Percent_Identity=43.4049079754601, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=652, Percent_Identity=43.4049079754601, Blast_Score=497, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90160; Mature: 90029

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKEKHFEEYAALATLPLRDVVVYPHMVLPLFVGRPKSIAALENAITREEPVFLLAQTD
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECC
AAVEEPVAADLYQTGTVAQVLQVLKLPDGTVKVLVEGLYRGRVLTIEDTGGLFVSHIETV
HHHHCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHH
VEEDTGGNTDLEAVRRTLLAQFEQYAKLNKKIPAEIIGSINGIAENSRLTDTVAAHLQLK
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LAQRQQILEIPEIGKRMEFLLAQLESELDIMQAEKRIRGRVKRQMEKSQREYYLNEQIKA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHKELGEEDENGELDALEAGIKKAGMSKEAEEKCLSELKKLKMMPPMSAESTVVRNYIDT
HHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LLELPWKKKSRVSKDIAKAGLVLDADHYGMEKVKERILEYLAVQKRMDKLKGPILCLVGP
HHHCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
PGVGKTSLGESIAKATGRKYVRMALGGVRDESEIRGHRRTYIGSMPGKILQNMAKAGVKN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHCCCCHHHHHHHHHCCCCC
PLFLLDEIDKLGSDFRGDPASALLEVLDPEQNNKFADHYAEVDYDLSDVMFIATSNSLNI
CHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCC
PTPLLDRMEIIRLSGYTEDEKINIAMQYLVPKQMKRNGVKEGELAIEESAVRDIIRYYTR
CCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EAGVRSLDREIAKICRKVVMQITLDEDSKTKKTGKAKPRAVKVNEKNLHDYLGVRRFDYG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHCCHHHCCC
VAESENRIGQVTGLAWTEVGGELLTVEAAALPGKGVIQCTGQLGDVMKESVSAAWSVVRS
CCCCCCCCHHHHCCHHHHCCCEEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
RAESVGLAPDFYEKKDIHVHVPEGATPKDGPSAGIAMTLAMVSAFTKIPVRADVAMTGEI
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECEEEECEE
TLRGEVLPIGGLKEKLLAALRGGIKHVLIPKDNLKDLEEIPENVKTGLTIHPVKWIDEVL
EEECEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEECHHHHHHHHH
ALGLESQPEPWAEPSGAEAAAESASKPKPRSRATKH
HCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQKEKHFEEYAALATLPLRDVVVYPHMVLPLFVGRPKSIAALENAITREEPVFLLAQTD
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECC
AAVEEPVAADLYQTGTVAQVLQVLKLPDGTVKVLVEGLYRGRVLTIEDTGGLFVSHIETV
HHHHCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHH
VEEDTGGNTDLEAVRRTLLAQFEQYAKLNKKIPAEIIGSINGIAENSRLTDTVAAHLQLK
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LAQRQQILEIPEIGKRMEFLLAQLESELDIMQAEKRIRGRVKRQMEKSQREYYLNEQIKA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHKELGEEDENGELDALEAGIKKAGMSKEAEEKCLSELKKLKMMPPMSAESTVVRNYIDT
HHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LLELPWKKKSRVSKDIAKAGLVLDADHYGMEKVKERILEYLAVQKRMDKLKGPILCLVGP
HHHCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
PGVGKTSLGESIAKATGRKYVRMALGGVRDESEIRGHRRTYIGSMPGKILQNMAKAGVKN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHCCCCHHHHHHHHHCCCCC
PLFLLDEIDKLGSDFRGDPASALLEVLDPEQNNKFADHYAEVDYDLSDVMFIATSNSLNI
CHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCC
PTPLLDRMEIIRLSGYTEDEKINIAMQYLVPKQMKRNGVKEGELAIEESAVRDIIRYYTR
CCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EAGVRSLDREIAKICRKVVMQITLDEDSKTKKTGKAKPRAVKVNEKNLHDYLGVRRFDYG
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHCCHHHCCC
VAESENRIGQVTGLAWTEVGGELLTVEAAALPGKGVIQCTGQLGDVMKESVSAAWSVVRS
CCCCCCCCHHHHCCHHHHCCCEEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
RAESVGLAPDFYEKKDIHVHVPEGATPKDGPSAGIAMTLAMVSAFTKIPVRADVAMTGEI
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECEEEECEE
TLRGEVLPIGGLKEKLLAALRGGIKHVLIPKDNLKDLEEIPENVKTGLTIHPVKWIDEVL
EEECEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCEECHHHHHHHHH
ALGLESQPEPWAEPSGAEAAAESASKPKPRSRATKH
HCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]