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The map label for this gene is guaB [H]

Identifier: 161870048

GI number: 161870048

Start: 1065833

End: 1067329

Strand: Reverse

Name: guaB [H]

Synonym: NMCC_1084

Alternate gene names: 161870048

Gene position: 1067329-1065833 (Counterclockwise)

Preceding gene: 161870049

Following gene: 161870043

Centisome position: 49.56

GC content: 56.65

Gene sequence:

>1497_bases
GTGCATCTTGCACAAACTGAAAGACCGAGCATTATGCGTATCGTAGAAAAAGCCTATACTTTCGACGATGTTTTGTTGGT
TCCCGCACATTCGACTGTGCTGCCGCGAGACGTTAAACTTCAAACCAAGCTCACCCGCGAAATCACACTCAACCTCCCCC
TGCTTTCCGCCGCGATGGACACTGTTACCGAGGCGCGCCTCGCCATTTCGATGGCACAGGAAGGCGGCATCGGCATCATC
CATAAAAATATGCCGCCCGAAATGCAGGCGCGCGCCGTTTCCAAAGTGAAACGCCACGAAAGCGGCGTGGTCAAAGACCC
CGTAACCGTTGCGCCGACAACGCTCATCCGCGAAGTCTTGGAAATGCGTGCGCAGCGCAAACGCAAAATGTCCGGCCTGC
CCGTCGTTGAAAACGGCAAAGTCGTCGGCATCGTAACCAACCGCGACCTGCGTTTTGAAAACCGCGTCGATTTGCCCGTT
TCCGCCATTATGACCCCGCGCGAACGTCTGGTTACCGTCCCCGAAGGCACAAGCATAGACGAAGCGCGCGAACTGATGCA
CACGCACAAAGTCGAGCGCGTTTTGGTTCTGAACGAAAAAGACGAGCTTAAGGGCTTGATTACCGTCAAAGATATTTTAA
AAACCACCGAGTTTCCCAATGCCAACAAAGACTCCGAAGGCCGTCTGCGCGTCGGTGCGGCAGTCGGCACCGGCGGCGAT
ACCGAAGAACGCGTCAAAGCCTTGGTAGAAGCAGGAGTCGATGTCATCGTCGTCGATACCGCACACGGGCATAGCCAAGG
CGTAATCGATCGCGTTCGCTGGGTCAAAGAAACTTATCCGCACATCCAAGTCATCGGCGGCAACATCGCCACCGCCAAAG
CCGCATTGGATTTGGTCGCCGCCGGCGCGGATGCCGTCAAAGTCGGTATCGGTCCGGGATCGATTTGCACCACCCGTATC
GTGGCAGGCGTGGGCGTGCCGCAACTGACCGCCATTCACAACGTTGCCGAAGCCCTCAAAGGCACGGGCGTTCCGCTGAT
TGCCGACGGCGGCATCCGCTTCTCCGGCGACATCGCCAAAGCCCTCGCCGCAGGCGCGTACAGCGTCATGCTCGGCGGTA
TGTTTGCCGGCACGGAAGAAGCACCGGGCGAAATCGAACTCTACCAAGGCCGCTCGTACAAATCCTATCGCGGTATGGGT
TCCTTGGGCGCGATGAGCCAAGGTTCTGCCGACCGCTACTTCCAAGACAAAACCGACAGCACCGACAAATACGTCCCCGA
AGGCATCGAAGGCCGCGTTCCCTACAAAGGCCCGATTGTGAACATCATCCACCAACTGACCGGCGGACTGCGCTCCAGCA
TGGGGTATTTGGGTTGCGCCAATATTGCCGAAATGCACGAAAAAGCAGAATTTGTGGAAATCACTTCCGCAGGTATGAGC
GAATCGCACGTTCACGACGTTCAAATTACCAAAGAAGCACCGAACTACCATCGCTGA

Upstream 100 bases:

>100_bases
CGGGAGCAACAGTGGTCGGCAAAGGAAAACCGGGCTATTCAAAGGGGACCAAAATTAAACCTGATAAACTGTCAAGCCGC
CGGTAACGTGCTATAATGCC

Downstream 100 bases:

>100_bases
TTTGAACAGCTTTTTCAAGGCAAAATGCCGTCTGAAACCTGATTTTCGGGTTTCAGACGGCATTTTTTGTCCGTTCAAGG
CAAGCCGCACGGGCTGATTG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MHLAQTERPSIMRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGGIGII
HKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPV
SAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGD
TEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRI
VAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMG
SLGAMSQGSADRYFQDKTDSTDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMS
ESHVHDVQITKEAPNYHR

Sequences:

>Translated_498_residues
MHLAQTERPSIMRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGGIGII
HKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPV
SAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGD
TEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRI
VAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMG
SLGAMSQGSADRYFQDKTDSTDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMS
ESHVHDVQITKEAPNYHR
>Mature_498_residues
MHLAQTERPSIMRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGGIGII
HKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPV
SAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGD
TEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRI
VAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAKALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMG
SLGAMSQGSADRYFQDKTDSTDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMS
ESHVHDVQITKEAPNYHR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=41.407867494824, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=44.4690265486726, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=44.4690265486726, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=44.4690265486726, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=44.4690265486726, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=44.543429844098, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=43.5840707964602, Blast_Score=348, Evalue=9e-96,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=41.1504424778761, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI156104880, Length=259, Percent_Identity=37.8378378378378, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541956, Length=268, Percent_Identity=37.3134328358209, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI50541954, Length=268, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541952, Length=268, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541948, Length=268, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1788855, Length=491, Percent_Identity=64.3584521384929, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1786293, Length=245, Percent_Identity=35.5102040816327, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=37.6050420168067, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=40, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=36.5145228215768, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=40.4123711340206, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=39.7938144329897, Blast_Score=350, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=39.7938144329897, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=40.2366863905325, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=40.3361344537815, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=40.7484407484407, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=40.7484407484407, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=41.4027149321267, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53649; Mature: 53649

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLAQTERPSIMRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMD
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHEEEEEEEEECCHHHHHHHH
TVTEARLAISMAQEGGIGIIHKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVL
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
EMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPVSAIMTPRERLVTVPEGTSID
HHHHHHHHHCCCCCEEECCEEEEEEECCCCCCCCCCCCCHHHHCCCHHHEEECCCCCCHH
EARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGD
HHHHHHHHHHHCEEEEECCHHHHHHEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC
TEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVA
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
AGADAVKVGIGPGSICTTRIVAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAK
CCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHH
ALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDS
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
TDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCC
ESHVHDVQITKEAPNYHR
CCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MHLAQTERPSIMRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMD
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHEEEEEEEEECCHHHHHHHH
TVTEARLAISMAQEGGIGIIHKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVL
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
EMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPVSAIMTPRERLVTVPEGTSID
HHHHHHHHHCCCCCEEECCEEEEEEECCCCCCCCCCCCCHHHHCCCHHHEEECCCCCCHH
EARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGD
HHHHHHHHHHHCEEEEECCHHHHHHEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC
TEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVA
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
AGADAVKVGIGPGSICTTRIVAGVGVPQLTAIHNVAEALKGTGVPLIADGGIRFSGDIAK
CCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHH
ALAAGAYSVMLGGMFAGTEEAPGEIELYQGRSYKSYRGMGSLGAMSQGSADRYFQDKTDS
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
TDKYVPEGIEGRVPYKGPIVNIIHQLTGGLRSSMGYLGCANIAEMHEKAEFVEITSAGMS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCC
ESHVHDVQITKEAPNYHR
CCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA