Click here to switch to the map view.

The map label for this gene is cysJ

Identifier: 161870037

GI number: 161870037

Start: 1051683

End: 1053497

Strand: Reverse

Name: cysJ

Synonym: NMCC_1070

Alternate gene names: 161870037

Gene position: 1053497-1051683 (Counterclockwise)

Preceding gene: 161870038

Following gene: 161870036

Centisome position: 48.92

GC content: 58.51

Gene sequence:

>1815_bases
ATGAGTGAACACGATATGCAGAACACAAATCCGCCATTACCGCCTCTGCCGCCCGAAATCACGCAGCTCCTGTCGGGGCT
GGACGCGGCACAATGGGCGTGGCTGTCCGGCTACGCTTGGGCAAAAGCAGGAAACGGGGCATCTGCAGGACTGCCCGCGC
TTCAGACGGCATTGCCGACGGCAGAACCTTTTTCCGTAACCGTCCTTTCCGCCTCGCAAACCGGCAATGCGAAATCCGTT
GCCGACAAAGCGGCGGACAGCCTGGAAGCCGCCGGCATCCAAGTCAGTCGCGCCGAACTGAAAGACTATAAGGCGAAAAA
CATCGCCGGCGAACGCCGCCTGCTGCTGGTTACGTCCACCCAAGGCGAAGGCGAACCGCCGGAAGAAGCCGTCGTGCTGC
ACAAACTGCTGAACGGCAAAAAAGCCCCGAAATTGGACAAACTCCAATTTGCCGTACTGGGTTTGGGCGACAGTTCCTAT
CCGAATTTCTGCCGGGCGGGCAAAGATTTCGACAAACGTTTTGAAGAATTGGGGGCGAAACGCCTGCTCGAACGCGTTGA
TGCGGATTTGGACTTTGCCGCCGCCGCAAACGCCTGGACAGACAATATCGCCGCACTCTTAAAAGAAGAAGCCGCAAAAA
ACCGGGCAACGCCCGCGCCGCAGGCAACGCCCCCCGCCGGCCTTCAGACGGCATCGGAGGGCAGGTACTGCAAGGCAGAC
CCCTTTCCCGCCGCCCTGCTGGCCAATCAGAAAATCACCGCCCGCCAATCCGATAAAGACGTGCGCCACATCGAAATCGA
TTTGAGCGGTTCGGATTTGCACTACCTCCCGGGCGACGCGCTCGGCGTTTGGTTTGACAACGATCCGGCACTGGTCAGGG
AAATCCTAGACCTGCTCGGCATCGATCCGGCAACGGAAATACAGGCGGGCGGAAAAACCCTGCCGGTTGCCTCCGCACTG
TTATCCCATTTTGAACTCACGCAAAACACCCCCGCCTTTGTCAAAGGCTATGCCCCGTTCGCCGATGATGACGAACTCGA
CCGTATTGCTGCCGACAACGCCGTTTTGCAAGGCTTTGTGCAAAGCACGCCGATTGCCGATGTGCTGCACCGCTTCCCGG
CAAAACTGACGGCGGAACAATTCGCCGGCCTGCTTCGCCCGCTTGCGCCGCGCCTGTATTCGATTTCCTCGTCGCAGGCG
GAAGTGGGGGACGAAGTGCACCTGACCGTCGGCGCGGTGCGTTTTGAACACGAAGGGCGCGCCAGGGTGGGCGGCGCATC
GGGTTTCCTTGCCGACCGGCTGGAAGAGGACGGCACGGTGCGCGTGTTTGTGGAACGCAACGACGGCTTCAGGCTGCCCG
AAGACAGCCGCAAGCCGATTGTGATGATCGGCTCGGGCACCGGCGTCGCACCGTTCCGCGCTTTCGTCCAACAACGTGCC
GCAGAAAATGCGGAAGGCAAAAACTGGCTGATTTTCGGCAATCCGCATTTTGCCGCCGACTTCCTCTATCAGACCGAATG
GCAGCAGTTTGCCAAAGACGGCTTCCTGCACAGGTACGATTTCGCCTGGTCCCGCGATCAGGAAGAAAAAATCTATGTGC
AGGACAAAATCCGCGAACAGGCGGAAGGACTTTGGCAATGGCTGCAGGAAGGCGCGCATATCTATGTGTGCGGCGATGCG
GCAAAAATGGCAAAAGACGTGGAAGCCGCCTTGCTGGATGTGATTATCGGGGCAGGACATTTGGACGAAGAGGGCGCAGA
AGAATATTTGGATATGCTGCGCGAAGAAAAACGCTATCAGCGTGATGTTTATTGA

Upstream 100 bases:

>100_bases
AACCCGTTACGGCAACGCCTTATGCGGAAAACACCGCCGCCGGTTCGTTTATCCTGATAGACGAAGCGACATACGGCACT
GTTGCGGCAGGTATGATTTT

Downstream 100 bases:

>100_bases
TTAAATATAATCGGGAGGAACACAAAATGACCGTACAGACCAAGACAAAAGGTTTGGCGTGGCAAGAAAAACCGCTATCC
GACAACGAACGTCTGAAAAC

Product: sulphite reductase alpha subunit

Products: NA

Alternate protein names: SiR-FP

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPTAEPFSVTVLSASQTGNAKSV
ADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTSTQGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSY
PNFCRAGKDFDKRFEELGAKRLLERVDADLDFAAAANAWTDNIAALLKEEAAKNRATPAPQATPPAGLQTASEGRYCKAD
PFPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPATEIQAGGKTLPVASAL
LSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFVQSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQA
EVGDEVHLTVGAVRFEHEGRARVGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRA
AENAEGKNWLIFGNPHFAADFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDA
AKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVY

Sequences:

>Translated_604_residues
MSEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPTAEPFSVTVLSASQTGNAKSV
ADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTSTQGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSY
PNFCRAGKDFDKRFEELGAKRLLERVDADLDFAAAANAWTDNIAALLKEEAAKNRATPAPQATPPAGLQTASEGRYCKAD
PFPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPATEIQAGGKTLPVASAL
LSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFVQSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQA
EVGDEVHLTVGAVRFEHEGRARVGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRA
AENAEGKNWLIFGNPHFAADFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDA
AKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVY
>Mature_603_residues
SEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPTAEPFSVTVLSASQTGNAKSVA
DKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTSTQGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYP
NFCRAGKDFDKRFEELGAKRLLERVDADLDFAAAANAWTDNIAALLKEEAAKNRATPAPQATPPAGLQTASEGRYCKADP
FPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPATEIQAGGKTLPVASALL
SHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFVQSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQAE
VGDEVHLTVGAVRFEHEGRARVGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAA
ENAEGKNWLIFGNPHFAADFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDAA
KMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain

Homologues:

Organism=Homo sapiens, GI127139033, Length=601, Percent_Identity=28.9517470881864, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI24041029, Length=596, Percent_Identity=31.3758389261745, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI7657393, Length=593, Percent_Identity=29.1736930860034, Blast_Score=209, Evalue=8e-54,
Organism=Homo sapiens, GI221316709, Length=593, Percent_Identity=29.1736930860034, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI221316705, Length=602, Percent_Identity=28.7375415282392, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI10835173, Length=656, Percent_Identity=27.4390243902439, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI221316707, Length=525, Percent_Identity=28.3809523809524, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI40254422, Length=647, Percent_Identity=26.7387944358578, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI169790956, Length=513, Percent_Identity=27.6803118908382, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI169790958, Length=513, Percent_Identity=27.6803118908382, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1789123, Length=605, Percent_Identity=55.0413223140496, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554134, Length=592, Percent_Identity=30.0675675675676, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17566446, Length=577, Percent_Identity=25.8232235701906, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17531441, Length=413, Percent_Identity=24.9394673123487, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321832, Length=638, Percent_Identity=28.8401253918495, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321143, Length=390, Percent_Identity=29.7435897435897, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325305, Length=630, Percent_Identity=24.2857142857143, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137192, Length=601, Percent_Identity=26.955074875208, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI78706872, Length=532, Percent_Identity=31.5789473684211, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24583543, Length=532, Percent_Identity=31.5789473684211, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI78706876, Length=532, Percent_Identity=31.5789473684211, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24582192, Length=514, Percent_Identity=28.2101167315175, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24660907, Length=596, Percent_Identity=26.1744966442953, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24660903, Length=596, Percent_Identity=26.1744966442953, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24647438, Length=395, Percent_Identity=24.3037974683544, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSJ_NEIM0 (A9LZ73)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001599206.1
- ProteinModelPortal:   A9LZ73
- SMR:   A9LZ73
- EnsemblBacteria:   EBNEIT00000011319
- GeneID:   5796006
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_1070
- GeneTree:   EBGT00050000021818
- HOGENOM:   HBG736048
- OMA:   HVEIDLG
- ProtClustDB:   CLSK877924
- BioCyc:   NMEN374833:NMCC_1070-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01541
- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938
- Gene3D:   G3DSA:1.20.990.10
- PIRSF:   PIRSF000207
- PRINTS:   PR00369
- PRINTS:   PR00371
- TIGRFAMs:   TIGR01931

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1; SSF63380 Riboflavin_synthase_like_b-brl

EC number: =1.8.1.2

Molecular weight: Translated: 65913; Mature: 65782

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51384 FAD_FR; PS50902 FLAVODOXIN_LIKE

Important sites: BINDING 494-494

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPT
CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCC
AEPFSVTVLSASQTGNAKSVADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTST
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCEEEEEEEC
QGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYPNFCRAGKDFDKRFEELGAK
CCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHH
RLLERVDADLDFAAAANAWTDNIAALLKEEAAKNRATPAPQATPPAGLQTASEGRYCKAD
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCC
PFPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLG
CCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEEECCCHHHHHHHHHHHC
IDPATEIQAGGKTLPVASALLSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFV
CCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
QSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQAEVGDEVHLTVGAVRFEHEGR
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEEEEEEECCCC
ARVGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRA
CCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
AENAEGKNWLIFGNPHFAADFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQ
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEHHHHHHHHH
AEGLWQWLQEGAHIYVCGDAAKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQ
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RDVY
HCCC
>Mature Secondary Structure 
SEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPT
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHCCC
AEPFSVTVLSASQTGNAKSVADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTST
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCEEEEEEEC
QGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYPNFCRAGKDFDKRFEELGAK
CCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHH
RLLERVDADLDFAAAANAWTDNIAALLKEEAAKNRATPAPQATPPAGLQTASEGRYCKAD
HHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCC
PFPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLG
CCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCEEEEEECCCHHHHHHHHHHHC
IDPATEIQAGGKTLPVASALLSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFV
CCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
QSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQAEVGDEVHLTVGAVRFEHEGR
HCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEEEEEEECCCC
ARVGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRA
CCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
AENAEGKNWLIFGNPHFAADFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQ
HCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEHHHHHHHHH
AEGLWQWLQEGAHIYVCGDAAKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQ
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RDVY
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA