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The map label for this gene is ggt [H]

Identifier: 161869940

GI number: 161869940

Start: 974367

End: 976103

Strand: Reverse

Name: ggt [H]

Synonym: NMCC_0973

Alternate gene names: 161869940

Gene position: 976103-974367 (Counterclockwise)

Preceding gene: 161869943

Following gene: 161869939

Centisome position: 45.33

GC content: 47.38

Gene sequence:

>1737_bases
ATGACAATCTCTGGATGTCAAGTCATCCATGCCAATCAAGGTAAGGTTAATACTCATTCTGCTGTCATCACAGGTGCAGA
CGCTCACACGCCTGAACATGCAACGGGACTGACCGAACAAAAGCAGGTGATTGCAAGTGATTTTATGGTAGCGTCAGCCA
ATCCATTAGCAACACAAGCTGGCTATGATATCTTAAAGCAAGGCGGTAGCGCTGCAGATGCGATGGTGGCGGTGCAGACG
ACACTAAGCTTGGTAGAGCCACAGTCGTCAGGCTTGGGCGGTGGAGCATTTGTGTTGTATTGGGATAATACCGCCAAAAC
ATTGACCACATTTGATGGGCGTGAGACGGCACCGATGCGTGCGACGCCGGAATTATTTTTGGATAAAGATGGTCAACCAT
TGAAATTTATGGAAGCGGTGGTCGGTGGTCGCTCGGTGGGTACGCCTGCTATCCCTAAACTGATGGAGACAATACATCAG
CGATACGGTGTATTGCCTTGGGGAAAATTATTTGATACGCCGATCCGCTTGGCAAAACAAGGCTTTGAGGTGTCGCCAAG
GCTTGCCATCTCGGTTGAGCAAAATCAGCAGCATTTGGCACGCTATCCAAAAACAGCCGCTTATTTTTTGCCGAATGGTG
TGCCGCTACAAGCAGGCAGCTTGCTGAAAAATTTAGAATTTGCTGACAGTGTTCAGGCGTTAGCAGCTCAAGGTGCAAAA
GCTCTGCATACTGGTAAATATGCCCAAAATATCGTTTCAGTTGTCCAAAATGCTAAGGATAACCCCGGTCAATTATCCTT
ACAAGATTTATCTGATTATCAAGTGGTGGAACGCCCGCCTGTTTGTGTGACTTATCGTATTTATGAAGTATGCGGTATGG
GTGCACCAAGCTCAGGTGGGATTGCTGTGGGTCAGATTTTGGGGATTTTAAATGAATTTTCACCCAATCAGGTGGGGTAT
GATGCTGAAGGTTTACGTCTCTTGGGCGACGCTTCTAGGCTTGCGTTTGCGGATCGTGATGTATATTTGGGCGACCCTGA
TTTTGTACCAGTACCCATTCGCCAGTTGATTTCTAAAGACTACCTAAAACATCGCAGCCAGCTGCTTGAGCAGTCGGATA
AGGCATTGCCTAGCGTATCTGCAGGCGATTTTATTCATGAGTGGGTGTCCTCACAAGCGATTGAGTTACCTTCTACCAGT
CATATATCAATTGTGGATAAGGCGGGCAATGTGCTATCAATGACGACTTCCATTGAAAATGCGTTTGGCTCAACTTTGAT
GGCAAATGGCTACCTGCTGAATAATGAGCTGACAGACTTTAGTTTTGAGCCAATAAAGCAGGGCAAACAGGTCGCCAATC
GTGTCGAGCCCGGCAAGAGACCACGCTCCTCAATGGCACCAACCATCGTATTTAAAGCAGGCAAGCCTTATATGGCAATC
GGCTCCCCAGGTGGTAGCCGTATCATTGGCTATGTCGCTAAGACGATTGTGGCACATAGTGACTGGAATATGGATATCCA
AGATGCCATCAGTGCACCCAATTTATTAAATCGCTTTGGTAACTATGAACTAGAAACGGGCACAACCGCCCTCCAGTGGC
AACAAGCATTAAATGATTTGGGCTATAAGACTGATGTGCGTGAGCTAAATTCAGGTGTTCAAGCCATTATTATCGAGCCA
AGCAGGCTGGTTGGTGGTGCCGATCCACGCCGAGAAGGTCGAGTGATGGGTGATTAG

Upstream 100 bases:

>100_bases
AAATACAATAATCAGCATGCCTTGTATGAATCATCAATCAAACTCAGGCGAAGGAGTGCTTGTGGCTAAAACATATTTAT
TGACTGCATTGATAATGTCT

Downstream 100 bases:

>100_bases
AGGTGAAGCTTGTATTTTGTGAATTTGACCGCATTTAAGTTAATTATTAAAATAGGGGGAAATTGTGAGTAATCAAACAA
AAATACAAGCCATCAAGCAA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MTISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQT
TLSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQ
RYGVLPWGKLFDTPIRLAKQGFEVSPRLAISVEQNQQHLARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAK
ALHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDYQVVERPPVCVTYRIYEVCGMGAPSSGGIAVGQILGILNEFSPNQVGY
DAEGLRLLGDASRLAFADRDVYLGDPDFVPVPIRQLISKDYLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTS
HISIVDKAGNVLSMTTSIENAFGSTLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAI
GSPGGSRIIGYVAKTIVAHSDWNMDIQDAISAPNLLNRFGNYELETGTTALQWQQALNDLGYKTDVRELNSGVQAIIIEP
SRLVGGADPRREGRVMGD

Sequences:

>Translated_578_residues
MTISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQT
TLSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQ
RYGVLPWGKLFDTPIRLAKQGFEVSPRLAISVEQNQQHLARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAK
ALHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDYQVVERPPVCVTYRIYEVCGMGAPSSGGIAVGQILGILNEFSPNQVGY
DAEGLRLLGDASRLAFADRDVYLGDPDFVPVPIRQLISKDYLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTS
HISIVDKAGNVLSMTTSIENAFGSTLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAI
GSPGGSRIIGYVAKTIVAHSDWNMDIQDAISAPNLLNRFGNYELETGTTALQWQQALNDLGYKTDVRELNSGVQAIIIEP
SRLVGGADPRREGRVMGD
>Mature_577_residues
TISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQTT
LSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQR
YGVLPWGKLFDTPIRLAKQGFEVSPRLAISVEQNQQHLARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAKA
LHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDYQVVERPPVCVTYRIYEVCGMGAPSSGGIAVGQILGILNEFSPNQVGYD
AEGLRLLGDASRLAFADRDVYLGDPDFVPVPIRQLISKDYLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTSH
ISIVDKAGNVLSMTTSIENAFGSTLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAIG
SPGGSRIIGYVAKTIVAHSDWNMDIQDAISAPNLLNRFGNYELETGTTALQWQQALNDLGYKTDVRELNSGVQAIIIEPS
RLVGGADPRREGRVMGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=490, Percent_Identity=31.4285714285714, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915090, Length=490, Percent_Identity=31.4285714285714, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915096, Length=490, Percent_Identity=31.4285714285714, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915094, Length=490, Percent_Identity=31.4285714285714, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI113429324, Length=482, Percent_Identity=29.8755186721992, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI113429326, Length=487, Percent_Identity=29.5687885010267, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI153266885, Length=563, Percent_Identity=29.4849023090586, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI153266901, Length=563, Percent_Identity=29.3072824156306, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI109148539, Length=517, Percent_Identity=28.4332688588008, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI153266907, Length=563, Percent_Identity=27.708703374778, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI30581157, Length=128, Percent_Identity=37.5, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI30581155, Length=128, Percent_Identity=37.5, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=544, Percent_Identity=36.5808823529412, Blast_Score=295, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI72000294, Length=493, Percent_Identity=31.237322515213, Blast_Score=193, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI212646519, Length=493, Percent_Identity=31.237322515213, Blast_Score=193, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI193208245, Length=560, Percent_Identity=29.4642857142857, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI193208247, Length=560, Percent_Identity=29.4642857142857, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17542894, Length=529, Percent_Identity=28.7334593572779, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17506189, Length=528, Percent_Identity=28.7878787878788, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI72001497, Length=312, Percent_Identity=24.0384615384615, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=312, Percent_Identity=24.0384615384615, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=489, Percent_Identity=28.0163599182004, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859893, Length=544, Percent_Identity=26.2867647058824, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077496, Length=485, Percent_Identity=26.1855670103093, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45551474, Length=560, Percent_Identity=27.5, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI161077880, Length=564, Percent_Identity=27.6595744680851, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI161077878, Length=562, Percent_Identity=27.5800711743772, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24642670, Length=560, Percent_Identity=27.5, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24642666, Length=560, Percent_Identity=27.5, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI18859741, Length=489, Percent_Identity=23.721881390593, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62122; Mature: 61991

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDFMVASANPLATQA
CCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHEEECCCCCHHHH
GYDILKQGGSAADAMVAVQTTLSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMR
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCC
ATPELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQRYGVLPWGKLFDTPIRLAKQ
CCCHHEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GFEVSPRLAISVEQNQQHLARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAK
CCCCCCEEEEEECCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHCHHHHHHHHHHHCCCH
ALHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDYQVVERPPVCVTYRIYEVCGMGAPSSGG
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHCCCCEEEEEEHHHHHCCCCCCCCC
IAVGQILGILNEFSPNQVGYDAEGLRLLGDASRLAFADRDVYLGDPDFVPVPIRQLISKD
CHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHEEECCCEEECCCCCCCHHHHHHHHHH
YLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTSHISIVDKAGNVLSMTTSIEN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCEEEEECCCCEEEEHHHHHH
AFGSTLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAI
HHCCHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEE
GSPGGSRIIGYVAKTIVAHSDWNMDIQDAISAPNLLNRFGNYELETGTTALQWQQALNDL
ECCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCCEEECCCCHHHHHHHHHHHC
GYKTDVRELNSGVQAIIIEPSRLVGGADPRREGRVMGD
CCCCHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TISGCQVIHANQGKVNTHSAVITGADAHTPEHATGLTEQKQVIASDFMVASANPLATQA
CCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHEEECCCCCHHHH
GYDILKQGGSAADAMVAVQTTLSLVEPQSSGLGGGAFVLYWDNTAKTLTTFDGRETAPMR
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCC
ATPELFLDKDGQPLKFMEAVVGGRSVGTPAIPKLMETIHQRYGVLPWGKLFDTPIRLAKQ
CCCHHEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GFEVSPRLAISVEQNQQHLARYPKTAAYFLPNGVPLQAGSLLKNLEFADSVQALAAQGAK
CCCCCCEEEEEECCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHCHHHHHHHHHHHCCCH
ALHTGKYAQNIVSVVQNAKDNPGQLSLQDLSDYQVVERPPVCVTYRIYEVCGMGAPSSGG
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHCCCCEEEEEEHHHHHCCCCCCCCC
IAVGQILGILNEFSPNQVGYDAEGLRLLGDASRLAFADRDVYLGDPDFVPVPIRQLISKD
CHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHEEECCCEEECCCCCCCHHHHHHHHHH
YLKHRSQLLEQSDKALPSVSAGDFIHEWVSSQAIELPSTSHISIVDKAGNVLSMTTSIEN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCEEEEECCCCEEEEHHHHHH
AFGSTLMANGYLLNNELTDFSFEPIKQGKQVANRVEPGKRPRSSMAPTIVFKAGKPYMAI
HHCCHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEE
GSPGGSRIIGYVAKTIVAHSDWNMDIQDAISAPNLLNRFGNYELETGTTALQWQQALNDL
ECCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCCEEECCCCHHHHHHHHHHHC
GYKTDVRELNSGVQAIIIEPSRLVGGADPRREGRVMGD
CCCCHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA